Protein Alignment Tep2 and a2m2e

DIOPT Version :10

• Sequence 1: NP_523506.1
• Gene: Tep2 / 34044
• FlyBaseID: FBgn0041182
• Length: 1420
• Species: Drosophila melanogaster
• Sequence 2: NP_001132951.1
• Gene: a2m2e / 100006972
• ZFINID: ZDB-GENE-090212-1
• Length: 1442
• Species: Danio rerio
• Alignment Length: 1525
• Identity: 428/1525 - (28%)
• Similarity: 700/1525 - (45%)
• Gaps: 291/1525 - (19%)

  Fly    14 ALLVNATGIYSVVGPGT---LRSNSK------YNVVVSVHKADGPSQIKVSLNGPSYNETKQIEL 69
            :|::|   ||.|.|..:   |:.|::      :|....:.:|:...:|||.|.|.|:..|::.:
Zfish    57 SLVMN---IYLVHGNQSTLLLQENAEQEFHRCFNFKAPLAEAESVQKIKVELQGESFKMTEERK- 117

  Fly    70 PPMSTQNVEFEVPKLATGNYNLSAEGVSGVVFKNSTKLNYADKKPSVFVQTDKATYKPADLVQFR 134
                                         |:||:        ..|..|:||||..|.|..:|.||
Zfish   118 -----------------------------VMFKS--------YDPLTFIQTDKPIYMPGQIVNFR 145

  Fly   135 ILFLDENTRPAKIEKPISVIIIDGAQ-NRIKQLSDVKLTKGVFSGELQLSEQPVLGTWKISVSVD 198
            ::.:|.|..|  :::..|:|:::.:| |||.|.::|..|:.:.....:|:.:...|.:|:...:
Zfish   146 VVTMDTNFAP--VDQQYSIIVLEDSQDNRIGQWTNVSSTRWILQRSYELNPECREGAYKLKAFI- 207

  Fly   199 GDNRETKSFEVDKYVLPKFEVIVDTPKAVVIADKVIKATIRAKYTYGKPVKGKATVSMERS---Y 260
            |:...:..|:|.|||||||||.|..||.|.:.::.:...:.||||||:||.||:.|.:.|:   |
Zfish   208 GERMSSHYFQVKKYVLPKFEVTVKKPKTVSVVEEELLIEVCAKYTYGQPVPGKSWVKVCRNPLPY 272

  Fly   261 GYFGDLNANGNKQEKTIDVDGKGHVEFD-----IIHWAQRGQYLPPIKLFAVVTEELTGNKQNAT 320
            ..|..|..     |:|:::...|....:     |::...:......:.:.||||||.|......:
Zfish   273 IIFFPLCL-----EETLEITKTGCAIHNFGLSMILNSTLKDNLKDSLHVEAVVTEEGTEITMTKS 332

  Fly   321 ATVVLHQQRYSIEPYERPEHFEANKSFIYQVVVKNVDGSPVTNSAKNVKIGFDKSYSYFHEPSPK 385
            .:|.|..:...|...:.|:.:|.......::.:.:...:|:.|  |.|.:...:::|
Zfish   333 ESVHLTYEIGKITLIDLPKTYEPGSVIEGKIKLSDFKDAPIPN--KEVYLLEGENWS-------- 387

  Fly   386 TRINFEAPVNENGIATFNVRLPD-------------SDSRYYRIFASFDGSENTIGSISK----F 433
            :::......:.:|:|:|::....             .|:|||.....:..::.....:.:    :
Zfish   388 SKLLLNLTTDSDGLASFSLNTSSLSKKDISLIANVYPDTRYYGYKTPYFSTDKKTVQLFRIATVY 452

  Fly   434 EPTPMS------REPLK----IQVNTKKPRLGEQVSFDVVSIEDLPY-FVYTIVARGNVILSDY- 486
            .||...      .:|||    |....|...:||       ::||... .||.:::||.::...:
Zfish   453 SPTLSELIIEDIEQPLKCGTEITATVKYYFVGE-------TVEDFSTDIVYMVLSRGVIVHHGFE 510

  Fly   487 -VDVPDGQK-----TYTVKFTPTFSMVPKATIYVYYVV-NNDLQFEEKTIDFEKEFSNSIDVS-A 543
             |:|.....     |.:.|.:....:.|...|..|.|: :.::....|.:|.||.|.|.:.:. :
Zfish   511 KVEVKSSSNGLASGTMSFKLSVGADVAPVVQILAYCVLPSENVIAANKRLDTEKCFGNKVSLQFS 575

  Fly   544 PTNAKPSEEVKLRIKTDADSFVGLLGVDQSVLLLKSGNDLSQDDIFNSLNIYQTSTPWMNGYGRY 608
            |..|.|.|:..|::.....|..||..||||||:|:||..|..|.|||.|.:...|
Zfish   576 PAKAVPGEKNTLQLSAQPGSLCGLSAVDQSVLILESGKRLDADKIFNLLPVQSVS---------- 630

  Fly   609 PGQTSGLVTLTNANYPYNTGPLVMSYVFEGSRHPWITRPR--------YR----VGIRGDSGDRI 661
                         .|||:.         |..:.....|||        |.    ||::..:...:
Zfish   631 -------------YYPYSV---------EDEQACLYVRPRRSVLTDNTYETLKSVGLKMATNLAV 673

  Fly   662 SFLSQSLNDRNL---KEILL----KQTP-----------------QRTTIRKEFPETWFFE---- 698
            . :...|:.|.|   |.:::    :..|                 ...|||..|||||.:|
Zfish   674 R-VPDCLSYRGLTYHKNLVMYPDHRPVPVMFALGMAGVDGPVGNSPSVTIRTVFPETWIWELAEV 737

  Fly   699 -NVGEEEFTLTKKIPDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRGEVI 762
             :.|..|..:|  :|||||:|....|.|:.| |:.|.. |:::.||||||:..:||||:.|||:.
Zfish   738 GDSGSAEVPVT--VPDTITTWETEAFCLSST-GLGLAP-PAQLTVFQPFFLELSLPYSIIRGEIF 798

  Fly   763 AIPVVIFNYLDKTLDADV---------VMDNSDQEYEFTEATNEVLEKAIDEVRRVKRVTIPANS 818
            .:...:||||.|.:...|         :..:||.:|.                     ..:.||.
Zfish   799 ELKATVFNYLSKCIMVKVSPAPSSDYTLKASSDDQYS---------------------SCLCANG 842

  Fly   819 GKSVSFMIRPKNVGFTTLKITATSALAG----------------DAIHQKLKVEPEGVTLFENRA 867
            .|:..:::.|..:|...:.::|.:..:.                |.:.:.|.|:.||:...|..:
Zfish   843 RKTFKWILTPSVLGVVNVTVSAEAEASQTVCDNEIVSVPERGRIDIVTRSLLVQAEGIEKTETNS 907

  Fly   868 VFINLKDQPEMSQSLDADIPNEVVPQSEFIEFSVVGDLLGPTLQNLDNLVRMPYGCGEQNMVNFV 932
            ..:..|.. .:|:.:|..:|.:|:..|.....||:||:||..||||..|:|||||||||||....
Zfish   908 WLLCPKGD-SLSEKVDLTLPKDVIEGSAKSSVSVIGDILGRALQNLHGLLRMPYGCGEQNMAVLS 971

  Fly   933 PNILVLKYLEVTGRKLPSVESKARKFLEIGYQRELTYKHDDGSYSAFGKSDASGSTWLTAYVMRS 997
            |||.:|:|||.|.:...::..||..||:.||||:|.|||.||:||.||..|  |:|||||:|:||
Zfish   972 PNIYILQYLENTKQLTSAIREKASSFLKSGYQRQLNYKHFDGAYSTFGYGD--GNTWLTAFVLRS 1034

  Fly   998 FHQAGTYTDIDPKVITAGLDFLVSKQKESGEFPEVGKLFDN-----ANQNPLALTSFVLLAFFEN 1057
            |.:|..||.|||::|.:..|:|:|::...|.|.:.|:||:|     .|.| :.:|:::..:..|.
Zfish  1035 FGKAQKYTFIDPQIIQSAKDWLISRRDSDGCFIQQGRLFNNRMKGGVNDN-VTMTAYITASLLEL 1098

  Fly  1058 HELIPKYQSAIKK---AVRYVAEEADKTDDQYSLAIAAVALQLAKHPQS-EKVIAKLESVARKEN 1118
            .  .|.....|.|   .:|.|.||...|   |:.|:.|....||:...: :::..|||.:|..:.
Zfish  1099 E--TPVTDPVITKGLSCLRSVIEEVKNT---YTTALLAYTFSLARDTNTRQQLFNKLEDLAISDG 1158

  Fly  1119 DRMWWSKATESTGEDGRVFHWKPRSNDVEITSYVLLALLEKDPAEK-----ALPIIKWLISQRNS 1178
            ..:.||::  ::.:|.       .|.||||:||||||:|..|....     |..|:.||:.|:|:
Zfish  1159 PLVHWSRS--ASADDS-------ASLDVEISSYVLLAVLTADSLTTADLGFANRIVSWLVKQQNA 1214

  Fly  1179 NGGFSSTQDTVIGLQALTKFAYKTGSGSGTMDIEFSSAGESKNTIKVNPENSLVLQTHDLPKSTR 1243
            .||||||||||:.||||:.:|.|..|..|:..:...|||:|.: ..||.:|.|:.|...|.....
Zfish  1215 YGGFSSTQDTVVALQALSLYATKVFSSDGSSTVTVQSAGDSHH-FDVNQDNKLLYQEKQLANVPG 1278

  Fly  1244 KVDFTAKGTGSAMVQLSYRYNLAEKEKKPSFKVTPTVK---DTPNQLLIVDVCAEYVPLEDADKD 1305
            |.....||:....||::..||:....:..:..:...::   :...|..|.|...:|    |..::
Zfish  1279 KYSIEVKGSACVSVQIAQFYNIPTPTEAKTLSIDAKIEGDCEALGQNFIFDFTVKY----DGPEE 1339

  Fly  1306 KDSNMAVMEIALPSGFVGDSTSLGKIQA--VDRVKRVETKNSDSTVVVYFDSLTPGDVRCLPLEA 1368
            | :|||:::|.|.|||..|:::||....  |..|:||::|  |..|:||...::........::.
Zfish  1340 K-TNMAIVDIKLLSGFTADTSALGTSSGTYVSLVERVDSK--DDHVIVYLKEISKNVAMNYQIQM 1401

  Fly  1369 SKAHAVAKQKPASVSLYDYYDT-ERKATEY 1397
            .:...|...|||.|.:||||.| ::...||
Zfish  1402 KQVLQVKNLKPAVVKVYDYYQTSDQSEIEY 1431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	YfaS	<72..1395	CDD:441940	409/1454 (28%)
		A2M_2	909..1198	CDD:239227	126/302 (42%)
a2m2e	NP_001132951.1	YfaS	<128..1386	CDD:441940	394/1366 (29%)
		A2M_2	948..1234	CDD:239227	126/302 (42%)