DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7025 and ECM14

DIOPT Version :9

Sequence 1:	NP_609133.2	Gene:	CG7025 / 34042	FlyBaseID:	FBgn0031930	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_012000.1	Gene:	ECM14 / 856533	SGDID:	S000001174	Length:	430	Species:	Saccharomyces cerevisiae

Alignment Length:	443	Identity:	129/443 - (29%)
Similarity:	221/443 - (49%)	Gaps:	52/443 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LNSLPIVLALVVLA-QGASFGQDERLRYDNYSVYKVKFETQAQ--RSILRKLAEDRENFRLWHEA 64
            :|||......|:|| .||..|..|  .|..|:||:...:..:.  |.::..|.:|   :.:|..:
Yeast     4 MNSLWGCFLFVLLAVTGAVQGLQE--DYSEYAVYRFTSDNYSTLVRDVIAPLTDD---YDVWTRS 63

  Fly    65 KDELHLMLSPGAFGELETEIQKTNVTAELFISNVQELID-----SEEAANLKA--SRDGTFGWTK 122
            .:.:.:.| |...||...:       .::.|.|:.|||.     |:..|..:|  ..|..|.:.:
Yeast    64 NNFIDIKL-PKEIGEQIND-------GQVIIDNMNELIQNTLPTSQMMAREQAVFENDYDFFFNE 120

  Fly   123 YNSLAEIYAWLDDILAAYPTITESFIVGQSYEGRTIRGIKIS--YKSNNP---GVLIESNIHARE 182
            |..|..||.|||.:..::|::.....:|:::|||.::.:.||  ...:||   .::|...|||||
Yeast   121 YRDLDTIYMWLDLLERSFPSLVAVEHLGRTFEGRELKALHISGNKPESNPEKKTIVITGGIHARE 185

  Fly   183 WITSATATW----LINEFLTSTDE--LVRDLAENHDWYIVPVLNVDGFVYTHEKDRMWRKTRQPS 241
            ||:.:|..|    |:|.:.:|..|  .:.||    |:.::||.|.||:.||...||:|||.||.:
Yeast   186 WISVSTVCWALYQLLNRYGSSKKETKYLDDL----DFLVIPVFNPDGYAYTWSHDRLWRKNRQRT 246

  Fly   242 EISSCIGADPNRNYDSHWMENEGASSNPCAEDYGGPKPFSEPEIQAMSEFVISIKD--KINVLLA 304
            .:..|:|.|.:.::...|   |.|.::.|:|:|.|..||...|..|..:::...|.  ||...:.
Yeast   247 HVPQCLGIDIDHSFGFQW---EKAHTHACSEEYSGETPFEAWEASAWYKYINETKGDYKIYGYID 308

  Fly   305 FHSYSQLLLSPYGHTKEEFPPNFDDMMEVAKAYGDAVESLP---YGTVYRYGSAAGILYP--ASG 364
            .|||||.:|.||.::.:..|.:.::::|::.....|:.|..   |..:.........::|  .:|
Yeast   309 MHSYSQEILYPYAYSCDALPRDLENLLELSYGLSKAIRSKSGRNYDVISACKDRGSDIFPGLGAG 373

  Fly   365 ATIDWAYNEQGVEISYTIEFRDTGRYGFILPPVHIIPNAEEALIGIAALLEKC 417
            :.:|:.|:.: ...::.::.||||.:||:|||.:|.|..:|.   .|||...|
Yeast   374 SALDFMYHHR-AHWAFQLKLRDTGNHGFLLPPENIKPVGKET---YAALKYFC 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7025	NP_609133.2	Propep_M14	36..103	CDD:280416	12/68 (18%)
CG7025	NP_609133.2	M14_CP_A-B_like	123..416	CDD:199844	96/310 (31%)
ECM14	NP_012000.1	M14_CP_A-B_like	121..425	CDD:349433	97/313 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1851
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	O	PTHR11705
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1730
SonicParanoid	1	1.000	-	-		X86
TreeFam	0	0.000	Not matched by this tool.
	8	7.790