DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7025 and cpa5

DIOPT Version :9

Sequence 1:	NP_609133.2	Gene:	CG7025 / 34042	FlyBaseID:	FBgn0031930	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_954965.1	Gene:	cpa5 / 246092	ZFINID:	ZDB-GENE-020514-1	Length:	419	Species:	Danio rerio

Alignment Length:	441	Identity:	169/441 - (38%)
Similarity:	254/441 - (57%)	Gaps:	43/441 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LNSLPIVLALVVLAQGASFGQDERLRYDNYSVYKVKFETQAQRSILRKLAEDRENFRL--WHEAK 65
            :..|.:::||.|    |.||   :..::...|:::..:.:||..:|::|.|:.|:..|  |.|..
Zfish     1 MKRLLVLIALFV----AVFG---KKTFEGDQVFRITPKDEAQIDLLKELTEEGEHLGLSVWMEPI 58

  Fly    66 DE---------LHLMLSPGAFGELETEIQKTNVTAELFISNVQELIDSEEAANLK----ASRDGT 117
            .|         .|.:.:..||      :....:...:.|.|||||:|.|:...:|    |.....
Zfish    59 LESLPLDLHVPFHSLQAVRAF------LAYNQIPYHIMIENVQELLDDEQRDMVKYRGLARSTDD 117

  Fly   118 FGWTKYNSLAEIYAWLDDILAAYPTITESFIVGQSYEGRTIRGIKISYKSNNPGVLIESNIHARE 182
            |.:|.|:.|..|.:::|.::|....:....::|||||.|.:..:|.|..:|.||:.|::.||:||
Zfish   118 FVYTTYHDLNSINSFMDMLVAENRNMVSKVVIGQSYEKRPLNVLKFSTGANRPGIWIDTGIHSRE 182

  Fly   183 WITSATATWLINEFLT--STDELVRDLAENHDWYIVPVLNVDGFVYTHEKDRMWRKTRQPSEISS 245
            |:|.|:..|...:.:.  ..|.::.|:..:||.::..|.|.|||||||.|||||||||:|:..||
Zfish   183 WVTQASGVWFAKKIVKDYGRDPVLTDILNSHDIFLEIVTNPDGFVYTHTKDRMWRKTRKPNPGSS 247

  Fly   246 CIGADPNRNYDSHWMENEGASSNPCAEDYGGPKPFSEPEIQAMSEFVISIKDKINVLLAFHSYSQ 310
            |:|.|||||:|:.: ...|:|:|||.|.|.||...||||::|:.:||.| ..||...::.|||||
Zfish   248 CVGVDPNRNWDAGF-GGGGSSNNPCTETYRGPSAHSEPEVKAIVDFVKS-HGKIKAFVSIHSYSQ 310

  Fly   311 LLLSPYGHT----KEEFPPNFDDMMEVAKAYGDAVESLPYGTVYRYGSAAGILYPASGATIDWAY 371
            :||.|||:|    |::     .::.|||:....:::|| |.|.|.|||....:|.|||.||||.|
Zfish   311 MLLYPYGYTYTAAKDK-----AELHEVARKAITSLQSL-YNTRYTYGSIITTIYQASGGTIDWTY 369

  Fly   372 NEQGVEISYTIEFRDTGRYGFILPPVHIIPNAEEALIGIAALLEKCKDLGY 422
            | ||::.|||.|.|||||||||||...|:|.|||..:.:.|::|..|:..|
Zfish   370 N-QGIKYSYTFELRDTGRYGFILPANQIVPTAEETWLALMAIMEHTKNNPY 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7025	NP_609133.2	Propep_M14	36..103	CDD:280416	19/77 (25%)
CG7025	NP_609133.2	M14_CP_A-B_like	123..416	CDD:199844	133/298 (45%)
cpa5	NP_954965.1	Propep_M14	27..100	CDD:280416	19/78 (24%)
cpa5	NP_954965.1	Peptidase_M14_like	118..417	CDD:299699	137/307 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593518
Domainoid	1	1.000	251	1.000	Domainoid score	I2056
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2817
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	O	PTHR11705
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1730
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.830