DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7025 and T06A4.3

DIOPT Version :9

Sequence 1:	NP_609133.2	Gene:	CG7025 / 34042	FlyBaseID:	FBgn0031930	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_001021611.1	Gene:	T06A4.3 / 171668	WormBaseID:	WBGene00020283	Length:	505	Species:	Caenorhabditis elegans

Alignment Length:	445	Identity:	135/445 - (30%)
Similarity:	216/445 - (48%)	Gaps:	56/445 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LRYDNYSVYKVKFETQAQRSILRKL---AEDRE-NFRLWHEAKDELHLMLSPGAFGELETE---- 83
            |...:::||::..::|.....:::|   |.|.: ||  |...||: |      .|.::..:
Worm    18 LSTQSFAVYRLLPKSQTDFQAIQRLYKNATDHDLNF--WKTGKDK-H------GFWDVMVDMKNS 73

  Fly    84 ------IQKTNVTAELFISNVQELIDSEEAANLKA-----------SRDGTFGWTKYNSLAEIYA 131
                  :|..:::....|.:|:.||...|  |.|.           |....:.:..|.|...:..
Worm    74 KYFLDFLQVNDISYIKTIDDVEGLITKHE--NNKTLSNMFPRLWDDSSSAHYDFHTYGSYQRMTD 136

  Fly   132 WLDDILAAYPTITESFIVGQSYEGRTIRGIKISYKSNNPGVL-IESNIHAREWITSATATWLINE 195
            |:..::..||.:.:...:|::.|||.|.|::|...|....:. |:..||||||....||.:.|::
Worm   137 WMKQLVVKYPKMVQYISIGKTTEGRNIDGVEIGGDSRTKKIFWIDGGIHAREWAAPHTALFFIHQ 201

  Fly   196 FLTSTDEL-VRDLAENHDWYIVPVLNVDGFVYTHEKD----RMWRKTRQPSEISS--------CI 247
            ..:..:|. ::.|.....:.:||.||.||:.:|....    |:|||.|...:...        |.
Worm   202 LTSRANEPGIKKLLNEITFVVVPCLNPDGYEFTRSSTNPHVRLWRKNRSKMQCRKDIWGRNRCCR 266

  Fly   248 GADPNRNYDSHWMENEGASSNPCAEDYGGPKPFSEPEIQAMSEFVIS--IKDKINVLLAFHSYSQ 310
            |.|.|||:|.|:.|: |.|.:||:|.|.||.||||||.:|:.:.::|  .|.:.:..:..|:|||
Worm   267 GVDLNRNFDFHFRES-GTSDDPCSEIYQGPSPFSEPEAKAVRDALLSQRYKGRTDAYITLHTYSQ 330

  Fly   311 LLLSPYGHTKEEFPPNFDDMMEVAKAYGDAVESLPYGTVYRYGSAAGILYPASGATIDWAYNEQG 375
            :.:.||||.|:.:|.:..|:.||.|....|::.: |||.|..||.|..||||||.:.|||.:|..
Worm   331 IWIHPYGHKKDAYPGDIKDLYEVGKKAAQALKRV-YGTKYVVGSGADTLYPASGGSEDWAKHEAK 394

  Fly   376 VEISYTIEFRDTGRY--GFILPPVHIIPNAEEALIGIAALLEKCKDLGYLGLKSA 428
            |:..|.:|.|...:.  ||||....:||.|.|...|:..:.|...|....|..:|
Worm   395 VKFVYLLELRPDEKNWDGFILDEKELIPTARETWEGVRVVAEAVLDRIVAGKSTA 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7025	NP_609133.2	Propep_M14	36..103	CDD:280416	15/80 (19%)
CG7025	NP_609133.2	M14_CP_A-B_like	123..416	CDD:199844	108/310 (35%)
T06A4.3	NP_001021611.1	Propep_M14	31..98	CDD:366995	14/75 (19%)
		M14_CP_A-B_like	128..438	CDD:349433	109/311 (35%)
		ShK	468..505	CDD:366702
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37541
Inparanoid	1	1.050	239	1.000	Inparanoid score	I2114
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47975
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		mtm4737
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.880