DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7025 and Y18H1A.9

DIOPT Version :9

Sequence 1:	NP_609133.2	Gene:	CG7025 / 34042	FlyBaseID:	FBgn0031930	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_490776.2	Gene:	Y18H1A.9 / 171666	WormBaseID:	WBGene00021213	Length:	488	Species:	Caenorhabditis elegans

Alignment Length:	432	Identity:	135/432 - (31%)
Similarity:	218/432 - (50%)	Gaps:	53/432 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 YSVYKVKFETQAQRSILRKLAEDRENFRLW---HEAKDELHLMLSPGAFGELETEIQKTNVTAEL 93
            ::|::|:..||.|..||..|..:......|   .||..|:|:|:|.....:...|:...::...:
Worm    21 FTVWRVQPTTQDQVDILHNLYLNDVKLDFWKSPSEAGKEVHVMISDEKTQQFMKELDDHSIKHSV 85

  Fly    94 FISNVQELIDSEEAANLKASRDG---------------TFGWTKYNSLAEIYAWLDDILAAYPTI 143
            .|.:||::|..:     |..||.               .|...:|:|.|::..:|:.:...||.:
Worm    86 MIDDVQKVIVEQ-----KEKRDKLRKQVRLHDWREQKVQFNLAQYHSFADVINYLNSLAITYPEL 145

  Fly   144 TESFIVGQSYEGRTIRGIKISYKSN---NPGVLIESNIHAREWITSATATWLINEFLTSTDE--L 203
            .....:|.::|||.|..|||:.|.|   ..|:.::..||||||::.:|..:.|::.:|..|:  .
Worm   146 VSVQPIGTTHEGRQIPLIKITNKRNGGTKRGIWVDGGIHAREWVSPSTVLYFIHQLVTQYDKDVQ 210

  Fly   204 VRDLAENHDWYIVPVLNVDGFVYTHEKD----RMWRKTR-------------QPSEISSCIGADP 251
            ::...:..:|||||:||.||:.|:...:    |:|||.|             ||...:.|.|.|.
Worm   211 IKQFVDQLEWYIVPLLNPDGYEYSRSSNDPEIRLWRKNRSPPKCIQQATGLFQPPTTTCCQGVDL 275

  Fly   252 NRNYDSHWMENE-GASSNPCAEDYGGPKPFSEPEIQAMSEFVISIKDKINVLLAFHSYSQLLLSP 315
            |||:|  |...: |:|::||:|.|.|...|||||..|:.:||  .:.:|:..|.||||||:|:.|
Worm   276 NRNFD--WFFGQVGSSTDPCSEIYQGAYAFSEPETAAVRDFV--QRHRISTFLTFHSYSQILMYP 336

  Fly   316 YGHTKEEFPPNFDDMMEVAKAYGDAVESLPYGTVYRYGSAAGILYPASGATIDWAYNEQGVEISY 380
            :||....:..:.:|:...|.:...|:.|: |.|.|:.|:.|..||||||.:.|||..:..|:.|:
Worm   337 FGHQVRTYSNDLNDLRSTALSAAQALNSV-YNTQYKVGTGADTLYPASGGSEDWAKGKAHVKYSF 400

  Fly   381 TIEFRDTGRY--GFILPPVHIIPNAEEALIGIAALLEKCKDL 420
            ..|.|...:.  ||:|....|||.|.|....:..:..|..:|
Worm   401 LFELRPEEQVWDGFLLAENQIIPTARETWEAVKVIASKTIEL 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7025	NP_609133.2	Propep_M14	36..103	CDD:280416	18/69 (26%)
CG7025	NP_609133.2	M14_CP_A-B_like	123..416	CDD:199844	109/317 (34%)
Y18H1A.9	NP_490776.2	Propep_M14	29..97	CDD:366995	18/67 (27%)
		M14_CP_A-B_like	125..436	CDD:349433	109/315 (35%)
		ShKT	454..487	CDD:214586
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37541
Inparanoid	1	1.050	239	1.000	Inparanoid score	I2114
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47975
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		mtm4737
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1730
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.810