DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18585 and Cpb1

DIOPT Version :9

Sequence 1:	NP_001260213.1	Gene:	CG18585 / 34041	FlyBaseID:	FBgn0031929	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_083982.1	Gene:	Cpb1 / 76703	MGIID:	1923953	Length:	415	Species:	Mus musculus

Alignment Length:	408	Identity:	145/408 - (35%)
Similarity:	236/408 - (57%)	Gaps:	16/408 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LVALTSAGILKDSPKERYDNFRVYKLTIQNKIQLAAIEKIGELTKKYNIWKEYDERSR-----QI 69
            |:||.|.. |..:.:|.:|..||:::::.::..::.|:::.. ||:.:.||. |..::     .:
Mouse     4 LLALVSVA-LAHASEENFDGNRVFRVSVHDEDDVSLIQELAN-TKQIDFWKP-DSATQVKPLTTV 65

  Fly    70 DIMVSPGELNHFQELLKFNNISSELMIENVQERIDEEQVTPTADSATFGWTKYYELEEIEAWLDE 134
            |..|...::...:..|:.|.:..|::|.|| :.|.|.|......::...:|||...|.||||:.:
Mouse    66 DFHVKAEDVVDVENFLEENEVLYEVLISNV-KHILESQFDSHTRASGHSYTKYNNWETIEAWIQQ 129

  Fly   135 ILNAYPSVTEEFIVGKSYEGRTIRGIKISHKAGN-PGIFIESNIHAREWITSASATWFINQLLTS 198
            :.|..|.:..:.::|.::|||.:..:||.....| |..||:...||||||:.|...||:.:.:.:
Mouse   130 VANDNPDLVSKRVIGTTFEGRNMYVLKIGKDRPNKPAFFIDCGFHAREWISPAFCQWFVREAVRT 194

  Fly   199 --EDADVRSLADNYDWHIIPVFNVDGFEYSHKKDRMWRKTRQPHATNACIGADANRNFDSYWLQN 261
              ::..::.|.|..|::::||.|:||:.|:..|||||||||...|.::|.|.|.|||||:.|.:
Mouse   195 YKQEIHMKRLLDELDFYVLPVVNIDGYVYTWAKDRMWRKTRSTTAGSSCFGVDPNRNFDAGWCE- 258

  Fly   262 NGASDNPCSETFAGDNPESEPEAKALVEYLTKIQDQISVYISFHSYGQYLLSPYGHTNEEFPENY 326
            .|||.:|||:|:.|..||||.|.|||.:::.:....|..|::.|||.|.:|.||.: :.:.||||
Mouse   259 VGASRSPCSDTYCGPTPESEKETKALADFIRQNLSSIKAYLTVHSYSQMMLYPYSY-DYKLPENY 322

  Fly   327 NDILTIGKAFADAIEALPYGTVYQYGSTADVLYVATGTSVDWVFNELGKKIGYTIEYRDKGRYGF 391
            .::..:.|..|..:..| :||.|.||..|..:|.|.|.|.||.::: |.|..:|.|.||||.:||
Mouse   323 EELNALVKGAAKELSTL-HGTKYTYGPGATTIYPAAGGSDDWAYDQ-GIKYSFTFELRDKGFFGF 385

  Fly   392 ILPPVQIIPNCEELMVGM 409
            :||..||...|||.|:.:
Mouse   386 LLPESQIRQTCEETMLAV 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18585	NP_001260213.1	Propep_M14	34..105	CDD:280416	15/75 (20%)
CG18585	NP_001260213.1	M14_CP_A-B_like	122..415	CDD:199844	117/291 (40%)
Cpb1	NP_083982.1	Propep_M14	31..102	CDD:396700	16/73 (22%)
Cpb1	NP_083982.1	M14_CPB	112..411	CDD:349443	119/296 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848064
Domainoid	1	1.000	233	1.000	Domainoid score	I2384
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3018
Isobase	1	0.950	-	0	Normalized mean entropy	S1851
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		mtm8747
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1730
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.680