DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18585 and AGBL5

DIOPT Version :9

Sequence 1:	NP_001260213.1	Gene:	CG18585 / 34041	FlyBaseID:	FBgn0031929	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_068603.4	Gene:	AGBL5 / 60509	HGNCID:	26147	Length:	886	Species:	Homo sapiens

Alignment Length:	417	Identity:	71/417 - (17%)
Similarity:	136/417 - (32%)	Gaps:	107/417 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 GELNHFQELLKFNNISSELMIENVQERIDEEQVTPTADSATFGWTKYYELEEIEAWLDEILNAYP 140
            |....|.....|:....:.::..:.:|..|...|.::...|.    ||..|.:...||.:.....
Human   148 GATTFFAFCYPFSYSDCQELLNQLDQRFPENHPTHSSPLDTI----YYHRELLCYSLDGLRVDLL 208

  Fly   141 SVTEEFIVGKSYEGR---------TIRGIKISHKAGNPGIFIESNIHAREWITSASATWFINQLL 196
            ::|....:.:..|.|         |.|..:.   ||....|:.|.:|..|..:|.....|::.:|
Human   209 TITSCHGLREDREPRLEQLFPDTSTPRPFRF---AGKRIFFLSSRVHPGETPSSFVFNGFLDFIL 270

  Fly   197 TSEDADVRSLADNYDWHIIPVFNVDG------------------------------------FEY 225
            ..:|...::|...:.:.:||:.|.||                                    ..|
Human   271 RPDDPRAQTLRRLFVFKLIPMLNPDGVVRGHYRTDSRGVNLNRQYLKPDAVLHPAIYGAKAVLLY 335

  Fly   226 SHKKDRMWRKTRQPHATNACIGADANRNFDSYWLQNNGASDNPCSETFAGDNPESEPEAKALVEY 290
            .|...|:..::...|..::|:..||  ........||..::..|..:....|.|:..:.:...:.
Human   336 HHVHSRLNSQSSSEHQPSSCLPPDA--PVSDLEKANNLQNEAQCGHSADRHNAEAWKQTEPAEQK 398

  Fly   291 LTKI---------------------QDQISVYISFHSY----GQYLLSPYGHT-NEEFP--EN-- 325
            |..:                     :..::.|:..|.:    |.::   ||:: ::|..  ||
Human   399 LNSVWIMPQQSAGLEESAPDTIPPKESGVAYYVDLHGHASKRGCFM---YGNSFSDESTQVENML 460

  Fly   326 YNDILTIGKAFADAIEALPYGTVYQY-----------GSTADVLYVATGTSVDWVFNELGKKIGY 379
            |..::::..|..| .:...:.....|           ||....:|.|:|....:.. |.....|.
Human   461 YPKLISLNSAHFD-FQGCNFSEKNMYARDRRDGQSKEGSGRVAIYKASGIIHSYTL-ECNYNTGR 523

  Fly   380 TIE-----YRDKGRYGFILPPVQIIPN 401
            ::.     ..|.||..  .||....|:
Human   524 SVNSIPAACHDNGRAS--PPPPPAFPS 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18585	NP_001260213.1	Propep_M14	34..105	CDD:280416	4/28 (14%)
CG18585	NP_001260213.1	M14_CP_A-B_like	122..415	CDD:199844	64/371 (17%)
AGBL5	NP_068603.4	M14_AGBL5_like	176..568	CDD:199860	67/389 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..364		4/21 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	605..734
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	784..848
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810