DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18585 and Cpa5

DIOPT Version :9

Sequence 1:	NP_001260213.1	Gene:	CG18585 / 34041	FlyBaseID:	FBgn0031929	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_001002808.2	Gene:	Cpa5 / 408212	RGDID:	1303098	Length:	436	Species:	Rattus norvegicus

Alignment Length:	409	Identity:	138/409 - (33%)
Similarity:	228/409 - (55%)	Gaps:	34/409 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 NF---RVYKLTIQNKIQLAAIEKIGELTK--KYNIWKEYDERSRQIDIMVSPGELNHFQELLKFN 88
            ||   :|.::..:|:.||:.:..: |:.|  |.:.|:.....|..:|:.|...||...:..||.:
  Rat    36 NFTGDQVLRVLAKNEKQLSLLRDL-EIQKPQKVDFWRGPARPSLPVDMRVPFSELPSVKAYLKSH 99

  Fly    89 NISSELMIENVQERIDEEQ----VTPTADSAT--FGWTKYYELEEIEAWLDEILNAYPSVTEEFI 147
            .::..:||:::|..:|||:    .:...:.:|  |.::.|:.||||..|:|..:..:.::..:..
  Rat   100 GLAYSVMIKDIQVLLDEERDAMARSRRLERSTNGFSYSSYHTLEEIYNWIDNFVAEHSNLVSKIH 164

  Fly   148 VGKSYEGRTIRGIKISHKAGNP---GIFIESNIHAREWITSASATWFINQLLT--SEDADVRSLA 207
            :|||:|.|:|..:|.|  .|.|   .|:|::.||:|||||.|:..|...:::.  |:|..::.:.
  Rat   165 IGKSFENRSILVLKFS--TGGPNRTAIWIDTGIHSREWITHATGIWISQKIVNAYSKDHVLKKVL 227

  Fly   208 DNYDWHIIPVFNVDGFEYSHKKDRMWRKTRQPHATNACIGADANRNFDSYW---LQNNGASDNPC 269
            :..|..|..|.|.|||.::|..:|:|||.:.......|:|.|.|||    |   ...||::.|||
  Rat   228 NTMDIFIEIVTNPDGFAFTHSMNRLWRKNKSIQPGIVCVGVDLNRN----WRTGFGGNGSNKNPC 288

  Fly   270 SETFAGDNPESEPEAKALVEYLTKIQDQISVYISFHSYGQYLLSPYGHTNEEFPENYNDILTIGK 334
            |||:.|..||||||..|:|.::|. .......||.|||.|.::.||||:.|..| |:.::..:.|
  Rat   289 SETYRGPAPESEPEVAAIVAFITG-HGNFKAMISIHSYSQMVMYPYGHSLEPVP-NHKELFELAK 351

  Fly   335 AFADAIEAL--PYGTVYQYGSTADVLYVATGTSVDWVFNELGKKIGYTIEYRDKGRYGFILPPVQ 397
               ||::||  .:|..|.:||.:..||.|:|.:|||.::. |.|..::.|.||.|:|||:||..|
  Rat   352 ---DAVKALYKVHGMEYIFGSISTTLYSASGITVDWAYDS-GIKYAFSFELRDTGQYGFLLPASQ 412

  Fly   398 IIPNCEELMVGMLALIEKT 416
            |:|..||..:.:..:::.|
  Rat   413 IVPTAEETWMALRTIMKHT 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18585	NP_001260213.1	Propep_M14	34..105	CDD:280416	17/72 (24%)
CG18585	NP_001260213.1	M14_CP_A-B_like	122..415	CDD:199844	112/302 (37%)
Cpa5	NP_001002808.2	Propep_M14	48..117	CDD:396700	18/69 (26%)
Cpa5	NP_001002808.2	M14_CPA	134..434	CDD:349442	114/310 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351677
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	262	1.000	Inparanoid score	I3014
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		mtm8990
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	O	PTHR11705
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.800