DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18585 and CG18417

DIOPT Version :9

Sequence 1:	NP_001260213.1	Gene:	CG18585 / 34041	FlyBaseID:	FBgn0031929	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_648119.1	Gene:	CG18417 / 38829	FlyBaseID:	FBgn0035780	Length:	427	Species:	Drosophila melanogaster

Alignment Length:	432	Identity:	143/432 - (33%)
Similarity:	236/432 - (54%)	Gaps:	30/432 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRLLWLLATLVALT-SAGILKDSPKERYDNFRVYKLTIQNKIQLAAIEKIGELTKKYNIWKEYDE 64
            |.::|::..|..|: |||:.:.:   :|:.:::|:::.:.: .:|..|.:.||.|..:.::.:.|
  Fly     1 MTVVWVILALSCLSLSAGLQRTN---KYEGYKIYEVSSEAR-SVAFSEALSELVKNASYYEVFSE 61

  Fly    65 --RSRQIDIMVSPGELNHFQELLKFNNISSELMIENVQERIDEEQVT--------PTADSATFGW 119
              ......|||.|.|..:|.:|::.||:..:::..||...:..:..|        |.  :...|.
  Fly    62 LNAGNPGKIMVHPHEQVNFVQLMEENNVKYDIINRNVGLTLSRQFETNRMLRHWFPY--NGRLGT 124

  Fly   120 TKYYELEEIEAWLDEILNAYPSVTEEFIVGKSYEGRTIRGIKISH---KAGNPGIFIESNIHARE 181
            .:||..|||..:::::...:|.......||:|||||.::.|.|::   :.....|.::...||||
  Fly   125 ERYYNHEEINQFIEDLAGEHPRRVFLKTVGRSYEGRWLKTITITNGDARRNKNVILVDGGFHARE 189

  Fly   182 WITSASATWFINQLLTSEDADVRSLADNYDWHIIPVFNVDGFEYSHKKD--RMWRKTRQPHATNA 244
            ||:.|:||:.||||:.:.:.:...|.| :||.|:||.|.||:||:...:  |||||||:|.:::
  Fly   190 WISPAAATYLINQLVYNLEDNADLLLD-FDWVILPVVNPDGYEYTQLSEDTRMWRKTRKPSSSD- 252

  Fly   245 CIGADANRNFDSYWLQNNGASDNPCSETFAGDNPESEPEAKALVEYLTKIQDQISVYISFHSYGQ 309
            |||.|.|||||.:| ...||||:||...:||..|.|||||..:.:.:....|:..:|::.||||.
  Fly   253 CIGTDPNRNFDFHW-NEEGASDDPCDNIYAGAKPFSEPEALVVGDLIHSYVDRGQMYLTLHSYGS 316

  Fly   310 YLLSPYGHTNEEFPENYNDILTIGKAFADAIEALPYGTVYQYGSTADVL-YVATGTSVDWVFNEL 373
            .:|.|:|.| ...|:...|:..:..|...||:... ||:|:.|.:|..: |.|:|.|.|:.|| .
  Fly   317 LILYPWGWT-AAVPDTEEDLHEVAAAGQSAIQEAT-GTIYKIGPSATTINYAASGASDDYAFN-A 378

  Fly   374 GKKIGYTIEYRDKGRYGFILPPVQIIPNCEELMVGMLALIEK 415
            |..|.:|:|. ..|..||..|...|....:|..||:.|:..|
  Fly   379 GFPISFTMEL-PFGGTGFDPPASDIDSIVKETWVGIAAMARK 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18585	NP_001260213.1	Propep_M14	34..105	CDD:280416	17/72 (24%)
CG18585	NP_001260213.1	M14_CP_A-B_like	122..415	CDD:199844	113/298 (38%)
CG18417	NP_648119.1	Propep_M14	<65..99	CDD:280416	10/33 (30%)
CG18417	NP_648119.1	M14_CP_A-B_like	127..420	CDD:199844	114/300 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466985
Domainoid	1	1.000	158	1.000	Domainoid score	I1007
eggNOG	1	0.900	-	-		E1_COG2866
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1851
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		otm46992
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	P	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	10	9.700