DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18585 and CG17633

DIOPT Version :9

Sequence 1:	NP_001260213.1	Gene:	CG18585 / 34041	FlyBaseID:	FBgn0031929	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_609310.2	Gene:	CG17633 / 34297	FlyBaseID:	FBgn0032144	Length:	430	Species:	Drosophila melanogaster

Alignment Length:	431	Identity:	164/431 - (38%)
Similarity:	248/431 - (57%)	Gaps:	25/431 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLATLVALTSAGILKDSPKERYDNFRVYKLTIQNKIQLAAIEKIGELTKKYNIWKEYDERSRQID 70
            |.|.|..:.||.:  .:.:.||||:|:||:..:|..||..::.:...:...............|.
  Fly     8 LFALLAIVASASV--SAERVRYDNYRMYKVNSENAKQLEVLKDLEGSSDSIMFLDGVHLVGADIQ 70

  Fly    71 IMVSPGELNHFQELLKFNNISSELMIENVQERIDE--EQVTPTADSAT-FGWTKYYELEEIEAWL 132
            |:|:|.::..|.|:|..:.|..||...:||:.:||  |:|.....:.| :.|.:||||::..|||
  Fly    71 IIVAPHKVPDFLEILGKSEIKYELQSRDVQKSLDEIDEKVAIKGRATTAYNWAQYYELDDTYAWL 135

  Fly   133 DEILNAYPSVTEEFIVGKSYEGRTIRGIKISHKAG-------NPGIFIESNIHAREWITSASATW 190
            ..:....|.|......||:|:||:|.|:||: |.|       .||||:|:.|||||||..|:||:
  Fly   136 QSLAQTNPGVVTLIEGGKTYQGRSILGVKIT-KGGETINGKAKPGIFLEAGIHAREWIAPAAATF 199

  Fly   191 FINQLLTSEDADVRSLADNYDWHIIPVFNVDGFEYSHKKDRMWRKTRQPHATNACIGADANRNFD 255
            .||||||||..:::.||:||.|:::|..|.||:.|:|..:|:|||||.|:  .:|.|||.|||:.
  Fly   200 IINQLLTSEVENIKELAENYTWYVLPHANPDGYVYTHTTNRLWRKTRTPY--GSCFGADPNRNWG 262

  Fly   256 SYWLQNNGASDNPCSETFAGDNPESEPEAKALVEYLTKIQDQISVYISFHSYGQYLLSPYGHTNE 320
            .:| ...|||.:.||:|:||.:..||.|..:|.:::..::.::.:|:|.|:|.||||.|||||:
  Fly   263 FHW-NEVGASSSACSDTYAGPSAFSEIETLSLSKFIEGLKGKVQLYLSLHAYSQYLLYPYGHTS- 325

  Fly   321 EFPENYNDILTIGKAFADAIEAL--PYGTVYQYGSTADVLYVATGTSVDWVFNELGKKIGYTIEY 383
            :.|:|..|   ..|.|..:|.|:  .|||.|..|:..|.:|.|.|.||||.:.....::.:..|.
  Fly   326 DLPDNVAD---FEKVFDASIAAVNKRYGTTYTGGNIYDAIYPAAGASVDWAYGTQDVRMAFCYEL 387

  Fly   384 RDKGR---YGFILPPVQIIPNCEELMVGMLALIEKTKELGY 421
            |....   .||.||..||:|..|||:..::|:..:.|.|||
  Fly   388 RPSSTSYLTGFKLPAEQIVPASEELLDSIVAMATEVKSLGY 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18585	NP_001260213.1	Propep_M14	34..105	CDD:280416	16/70 (23%)
CG18585	NP_001260213.1	M14_CP_A-B_like	122..415	CDD:199844	127/304 (42%)
CG17633	NP_609310.2	MpaA	7..374	CDD:225421	147/375 (39%)
		Propep_M14	34..105	CDD:280416	16/70 (23%)
		M14_CP_A-B_like	125..423	CDD:199844	127/305 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467033
Domainoid	1	1.000	158	1.000	Domainoid score	I1007
eggNOG	1	0.900	-	-		E1_COG2866
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	239	1.000	Inparanoid score	I2114
Isobase	1	0.950	-	0	Normalized mean entropy	S1851
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		mtm6559
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	P	PTHR11705
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1730
SonicParanoid	1	1.000	-	-		X86
	13	12.780