DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18585 and CG8945

DIOPT Version :9

Sequence 1:	NP_001260213.1	Gene:	CG18585 / 34041	FlyBaseID:	FBgn0031929	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_573190.1	Gene:	CG8945 / 32693	FlyBaseID:	FBgn0030815	Length:	1430	Species:	Drosophila melanogaster

Alignment Length:	490	Identity:	143/490 - (29%)
Similarity:	225/490 - (45%)	Gaps:	88/490 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLWLLATLVALTSAGILK--------DSPKE-RYDNFRVYKLTIQNKIQLAAIE--KIGELTKKY 56
            ||..|||  .:|:.|...        |.|:. .||.:::::|..|::.|:.|:|  |.||...|.
  Fly   950 LLQALAT--RMTTRGTTSTTTTTSRPDVPRRISYDKYQIWRLKPQDEEQVRALEEFKKGEDGVKL 1012

  Fly    57 NIWKEYDERSRQIDIMVSPGELNHFQELLKFNNISSELMIENVQERI-------DEEQVT----- 109
            . |.:........|::|.|..|..||..|.:..|:.|::|.:|.:.|       |..|.|
  Fly  1013 Q-WLKGPSLRGLTDVLVPPKMLVDFQGTLNYEGIAHEVLIFDVGKAIAYELTKEDYLQTTRPSKP 1076

  Fly   110 -PTADSATFGWTKYYELEEIEAWLDEILNAYPSVTEEFIVGKSYEGRTIRGIKISHK-----AGN 168
             ||| .....|.:|:..:||..:|:.:...:|.:.|...:|:|:|||.:..:||..|     |.|
  Fly  1077 RPTA-PPPMTWNRYHNHDEIVKYLETVRMRHPQLVELIHIGRSFEGRPLIVVKIESKQTAAAANN 1140

  Fly   169 PG------------------IFIESNIHAREWITSASATWFINQLL-------TSEDAD-VRSLA 207
            .|                  :|:|:......||..|:|||.|.:||       ::||.: :|
  Fly  1141 DGLHTIKRPKRKRKSGQANAVFVEAGAQGLAWIGPAAATWMIAELLRLMKTNKSNEDVEFIR--- 1202

  Fly   208 DNYDWHIIPVFNVDGFEYSHKKDRMWRKTRQPHAT---------------------NACIGADAN 251
             |..|:|:||.|.||:.|||:.||.|:|:|..|.|                     ..|.|.|.:
  Fly  1203 -NTTWYIMPVLNPDGYAYSHEYDRFWKKSRSQHQTPPPSGLLDSAMTWLQQKRGPDKVCYGVDLD 1266

  Fly   252 RNFDSYWLQNNGASDNPCSETFAGDNPESEPEAKALVEYLTKIQDQISVYISFHSYGQYLLSPYG 316
            ||:..:| ...|:|..||:|.:||..|.||||.||:.|:|...:.||.:|||..:|||.:..|..
  Fly  1267 RNWLYHW-GKRGSSKAPCNEFYAGPAPFSEPETKAVSEFLMDYRTQIKLYISLQAYGQVISYPVK 1330

  Fly   317 HTNEEFPENYNDILTIGKAFADAIEALPYGTVYQYGSTADVLYVATGTSVDWVFNELGKKIGYTI 381
            ..:....|..:|.|.:.....|.:......:.|:..::.|::...:|.:..:...|:|....||:
  Fly  1331 ANSTFNSERLDDFLDVAMVGTDGLRKKGSKSRYKVDASNDLIEQRSGCADAFAAYEIGIPFSYTL 1395

  Fly   382 EYRDKGRYGFILPPVQIIPNCE---ELMVGMLALI 413
            :..|.|.:|::||...|.|...   |::.|||..|
  Fly  1396 QLADNGVHGYLLPSSAIEPTARDAFEIISGMLDYI 1430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18585	NP_001260213.1	Propep_M14	34..105	CDD:280416	22/79 (28%)
CG18585	NP_001260213.1	M14_CP_A-B_like	122..415	CDD:199844	103/347 (30%)
CG8945	NP_573190.1	Propep_M14	988..1058	CDD:280416	21/70 (30%)
CG8945	NP_573190.1	M14_CP_A-B_like	1089..1430	CDD:199844	102/345 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.920