DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18585 and cpa1

DIOPT Version :9

Sequence 1:	NP_001260213.1	Gene:	CG18585 / 34041	FlyBaseID:	FBgn0031929	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_001018318.1	Gene:	cpa1 / 325886	ZFINID:	ZDB-GENE-050522-438	Length:	418	Species:	Danio rerio

Alignment Length:	434	Identity:	149/434 - (34%)
Similarity:	238/434 - (54%)	Gaps:	34/434 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLWLLATLVALTSAGILKDSPKERYDNFRVYKLTIQNKIQLAAIEKIGELTKK----YNIWKEYD 63
            ||.|.|..||:..        |..::..:|.::..:|..|::.::   |||:.    .:.|....
Zfish     4 LLVLTALFVAVFG--------KVTFEGDQVLRINAKNAEQISLLK---ELTEADLLGLDFWMNPA 57

  Fly    64 ERSRQIDIMVSPGELNHFQELLKFNNISSELMIENVQERIDEEQV---------TPTADSATFGW 119
            ..|..:|:.|....|...:..|.:|.|...:||||||:.:|:||:         ..|.|   |.:
Zfish    58 RESLPVDLHVPFHSLQAVRAFLAYNQIPYHIMIENVQDLVDKEQLQMLKYHGFPRSTDD---FVY 119

  Fly   120 TKYYELEEIEAWLDEILNAYPSVTEEFIVGKSYEGRTIRGIKISHKAGNPGIFIESNIHAREWIT 184
            |.|::|:.|..::|.::....::..:..:|:|||.|.:..:|.|..|..|||:|::.:|:|||||
Zfish   120 TTYHDLDSINLFMDMLVAENQNMVSKIEIGQSYENRPLNVLKFSTGANRPGIWIDTGLHSREWIT 184

  Fly   185 SASATWFINQLLT--SEDADVRSLADNYDWHIIPVFNVDGFEYSHKKDRMWRKTRQPHATNACIG 247
            .||..||..:::|  ..|..:..:.::||..:..|.|.||..|:|..||||||||:|:..::|:|
Zfish   185 HASGIWFAKKIVTDYGRDPVLTDILNSYDIFLEIVANPDGLAYTHSDDRMWRKTRKPNPGSSCVG 249

  Fly   248 ADANRNFDSYWLQNNGASDNPCSETFAGDNPESEPEAKALVEYLTKIQDQISVYISFHSYGQYLL 312
            .|.|||::: .....|:|.||||:|:.|.:..||||.||:||:: |....:..::|.|||.|.||
Zfish   250 VDPNRNWET-GFGGPGSSSNPCSQTYHGPSIHSEPEVKAIVEFV-KSHGNLKAFLSIHSYSQMLL 312

  Fly   313 SPYGHTNEEFPENYNDILTIGKAFADAIEALPYGTVYQYGSTADVLYVATGTSVDWVFNELGKKI 377
            .|||:| :...::..::..:.:.....:::| |.|.|.|||....:|.|.|.:.||.: |.|.|.
Zfish   313 YPYGYT-QTAAKDQAELHELARKATSELQSL-YNTAYTYGSIITTIYQADGVTTDWAY-EQGIKY 374

  Fly   378 GYTIEYRDKGRYGFILPPVQIIPNCEELMVGMLALIEKTKELGY 421
            .||.|.||.||||||||..||:|..||..:.::.::|..|...|
Zfish   375 SYTFELRDTGRYGFILPADQILPTAEETWLALMVIMEHIKNNPY 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18585	NP_001260213.1	Propep_M14	34..105	CDD:280416	19/74 (26%)
CG18585	NP_001260213.1	M14_CP_A-B_like	122..415	CDD:199844	112/294 (38%)
cpa1	NP_001018318.1	Propep_M14	27..99	CDD:280416	19/74 (26%)
cpa1	NP_001018318.1	Peptidase_M14_like	117..416	CDD:299699	116/303 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593515
Domainoid	1	1.000	251	1.000	Domainoid score	I2056
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2817
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		mtm6559
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	O	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.800