DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18585 and cpa5

DIOPT Version :9

Sequence 1:	NP_001260213.1	Gene:	CG18585 / 34041	FlyBaseID:	FBgn0031929	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_954965.1	Gene:	cpa5 / 246092	ZFINID:	ZDB-GENE-020514-1	Length:	419	Species:	Danio rerio

Alignment Length:	435	Identity:	155/435 - (35%)
Similarity:	255/435 - (58%)	Gaps:	33/435 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RLLWLLATLVALTSAGILKDSPKERYDNFRVYKLTIQNKIQLAAIEKIGELTKK-----YNIWKE 61
            |||.|:|..||:..        |:.::..:|:::|.:::.|   |:.:.|||::     .::|.|
Zfish     3 RLLVLIALFVAVFG--------KKTFEGDQVFRITPKDEAQ---IDLLKELTEEGEHLGLSVWME 56

  Fly    62 YDERSRQIDIMVSPGELNHFQELLKFNNISSELMIENVQERIDEEQ--------VTPTADSATFG 118
            ....|..:|:.|....|...:..|.:|.|...:|||||||.:|:||        :..:.|.  |.
Zfish    57 PILESLPLDLHVPFHSLQAVRAFLAYNQIPYHIMIENVQELLDDEQRDMVKYRGLARSTDD--FV 119

  Fly   119 WTKYYELEEIEAWLDEILNAYPSVTEEFIVGKSYEGRTIRGIKISHKAGNPGIFIESNIHAREWI 183
            :|.|::|..|.:::|.::....::..:.::|:|||.|.:..:|.|..|..|||:|::.||:|||:
Zfish   120 YTTYHDLNSINSFMDMLVAENRNMVSKVVIGQSYEKRPLNVLKFSTGANRPGIWIDTGIHSREWV 184

  Fly   184 TSASATWFINQLLT--SEDADVRSLADNYDWHIIPVFNVDGFEYSHKKDRMWRKTRQPHATNACI 246
            |.||..||..:::.  ..|..:..:.:::|..:..|.|.|||.|:|.|||||||||:|:..::|:
Zfish   185 TQASGVWFAKKIVKDYGRDPVLTDILNSHDIFLEIVTNPDGFVYTHTKDRMWRKTRKPNPGSSCV 249

  Fly   247 GADANRNFDSYWLQNNGASDNPCSETFAGDNPESEPEAKALVEYLTKIQDQISVYISFHSYGQYL 311
            |.|.|||:|: .....|:|:|||:||:.|.:..||||.||:|::: |...:|..::|.|||.|.|
Zfish   250 GVDPNRNWDA-GFGGGGSSNNPCTETYRGPSAHSEPEVKAIVDFV-KSHGKIKAFVSIHSYSQML 312

  Fly   312 LSPYGHTNEEFPENYNDILTIGKAFADAIEALPYGTVYQYGSTADVLYVATGTSVDWVFNELGKK 376
            |.|||:|... .::..::..:.:....::::| |.|.|.|||....:|.|:|.::||.:|: |.|
Zfish   313 LYPYGYTYTA-AKDKAELHEVARKAITSLQSL-YNTRYTYGSIITTIYQASGGTIDWTYNQ-GIK 374

  Fly   377 IGYTIEYRDKGRYGFILPPVQIIPNCEELMVGMLALIEKTKELGY 421
            ..||.|.||.||||||||..||:|..||..:.::|::|.||...|
Zfish   375 YSYTFELRDTGRYGFILPANQIVPTAEETWLALMAIMEHTKNNPY 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18585	NP_001260213.1	Propep_M14	34..105	CDD:280416	22/75 (29%)
CG18585	NP_001260213.1	M14_CP_A-B_like	122..415	CDD:199844	114/294 (39%)
cpa5	NP_954965.1	Propep_M14	27..100	CDD:280416	22/75 (29%)
cpa5	NP_954965.1	Peptidase_M14_like	118..417	CDD:299699	119/303 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593516
Domainoid	1	1.000	251	1.000	Domainoid score	I2056
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2817
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	O	PTHR11705
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1730
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.830