DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18585 and ZC434.9

DIOPT Version :9

Sequence 1:	NP_001260213.1	Gene:	CG18585 / 34041	FlyBaseID:	FBgn0031929	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_001251356.1	Gene:	ZC434.9 / 172908	WormBaseID:	WBGene00013895	Length:	720	Species:	Caenorhabditis elegans

Alignment Length:	464	Identity:	147/464 - (31%)
Similarity:	237/464 - (51%)	Gaps:	57/464 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LWLLATLVALT-SAGILKDSPKERYDNFRVYKLTIQNKIQLAAIEKIGELTK-KYNIWKEYDERS 66
            ||||..:.|.. :|.|..|.|.:    |:|.:....:..||.|:..|.|.|: ..:.|:...:..
Worm    10 LWLLILISAFAINAEIADDKPPK----FQVLRAHATDVPQLKALRDIHERTQHDLDFWQTPSKVG 70

  Fly    67 RQIDIMVSPGELNHFQELLKFNNISSELMIENVQERIDEEQVTPT---------------ADSAT 116
            .:.||||....:.....:||.:|||.:::||:|.:.|.|::..|.               .:.|.
Worm    71 HRADIMVDEDRMEWLDSVLKNSNISYDVIIEDVGKLILEKEHGPPRFSNLLFSKRMHNEGGNRAR 135

  Fly   117 FGWTKYYELEEIEAWLDEILNAYPSVTEEFIVGKSYEGRTIRGIKISHKA--GNPGIF-IESNIH 178
            :|:.:|:..:.|..|:.:|...||...:.|.:|.:.|||.|:||||..:.  .:..|| |:..||
Worm   136 YGFGEYHSYQTICDWMKDIERKYPDKAKVFTMGTTSEGRPIQGIKIGSQVWRNDKRIFWIDGGIH 200

  Fly   179 AREWITSASATWFINQLLT--SEDADVRSLADNYDWHIIPVFNVDGFEYSHKKD-----RMWRKT 236
            ||||....:|.|||::|:.  ::|:.||:..|..:::|:||.|.||:||| :.|     |:|||.
Worm   201 AREWAAVHTALWFIDRLIADYNDDSLVRAAVDRLNFYILPVANPDGYEYS-RSDVSPMIRLWRKN 264

  Fly   237 R--------QPHATNACIGADANRNFDSYW-LQNNGASDNPCSETFAGDNPESEPEAKALVEYLT 292
            |        :......|.|.|.|||:|  | ....|:|.:.|||.:.|.:..||.|.:::.::||
Worm   265 RAGVVCKKDRWFRDRCCGGVDLNRNYD--WHFGETGSSTDKCSEIYQGSSAFSESETRSMRDFLT 327

  Fly   293 --KIQDQISVYISFHSYGQYLLSPYGHTNEEFPENYNDILTIGKAFADAIEALPYGTVYQYGSTA 355
              ::..:|..:|:.|:|.|..:.||.|..:..|.:..::..:|:|...|:|. .|||.|::|:.:
Worm   328 SSELNGKIDAFITLHTYSQMWIHPYSHARKSVPADVAELQRVGRAAVAALEN-TYGTKYKFGTGS 391

  Fly   356 DVLYVATGTSVDWVFNELGKKIGYTIEYR------DKGRYGFILPPVQIIPNCEELMVGMLALIE 414
            |:||.:.|.|.||....|..|..|.:|.|      |    ||||...|:||..:|...|:..:|.
Worm   392 DILYPSAGGSDDWAKGTLRIKYVYLLELRPGEDVWD----GFILDQHQLIPTAKETWNGIKVVIR 452

  Fly   415 K-TKELGYL 422
            . |::.|.|
Worm   453 AVTEQAGSL 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18585	NP_001260213.1	Propep_M14	34..105	CDD:280416	20/71 (28%)
CG18585	NP_001260213.1	M14_CP_A-B_like	122..415	CDD:199844	109/319 (34%)
ZC434.9	NP_001251356.1	Propep_M14	45..111	CDD:366995	21/65 (32%)
		M14_CP_A-B_like	141..454	CDD:349433	109/320 (34%)
		ShK	682..719	CDD:366702
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37541
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		mtm4737
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.820