DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18585 and T06A4.3

DIOPT Version :9

Sequence 1:	NP_001260213.1	Gene:	CG18585 / 34041	FlyBaseID:	FBgn0031929	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_001021611.1	Gene:	T06A4.3 / 171668	WormBaseID:	WBGene00020283	Length:	505	Species:	Caenorhabditis elegans

Alignment Length:	443	Identity:	134/443 - (30%)
Similarity:	225/443 - (50%)	Gaps:	45/443 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLWLLATLVALTSAGILKDSPKERYDNFRVYKLTIQNKIQLAAIEKIGELTKKY--NIWKEYDER 65
            |::|..:.|:|::            .:|.||:|..:::....||:::.:....:  |.||...::
Worm     8 LIFLCFSAVSLST------------QSFAVYRLLPKSQTDFQAIQRLYKNATDHDLNFWKTGKDK 60

  Fly    66 SRQIDIMVSPGELNHFQELLKFNNISSELMIENVQERIDEEQVTPT-----------ADSATFGW 119
            ....|:||......:|.:.|:.|:||....|::|:..|.:.:...|           :.||.:.:
Worm    61 HGFWDVMVDMKNSKYFLDFLQVNDISYIKTIDDVEGLITKHENNKTLSNMFPRLWDDSSSAHYDF 125

  Fly   120 TKYYELEEIEAWLDEILNAYPSVTEEFIVGKSYEGRTIRGIKISHKAGNPGIF-IESNIHAREWI 183
            ..|...:.:..|:.:::..||.:.:...:||:.|||.|.|::|...:....|| |:..||||||.
Worm   126 HTYGSYQRMTDWMKQLVVKYPKMVQYISIGKTTEGRNIDGVEIGGDSRTKKIFWIDGGIHAREWA 190

  Fly   184 TSASATWFINQLLT-SEDADVRSLADNYDWHIIPVFNVDGFEYSHKKD----RMWRKTRQP---- 239
            ...:|.:||:||.: :.:..::.|.:...:.::|..|.||:|::....    |:|||.|..
Worm   191 APHTALFFIHQLTSRANEPGIKKLLNEITFVVVPCLNPDGYEFTRSSTNPHVRLWRKNRSKMQCR 255

  Fly   240 ----HATNACIGADANRNFDSYWLQNNGASDNPCSETFAGDNPESEPEAKALVEYL--TKIQDQI 298
                .....|.|.|.||||| :..:.:|.||:||||.:.|.:|.|||||||:.:.|  .:.:.:.
Worm   256 KDIWGRNRCCRGVDLNRNFD-FHFRESGTSDDPCSEIYQGPSPFSEPEAKAVRDALLSQRYKGRT 319

  Fly   299 SVYISFHSYGQYLLSPYGHTNEEFPENYNDILTIGKAFADAIEALPYGTVYQYGSTADVLYVATG 363
            ..||:.|:|.|..:.||||..:.:|.:..|:..:||..|.|::.: |||.|..||.||.||.|:|
Worm   320 DAYITLHTYSQIWIHPYGHKKDAYPGDIKDLYEVGKKAAQALKRV-YGTKYVVGSGADTLYPASG 383

  Fly   364 TSVDWVFNELGKKIGYTIEYR--DKGRYGFILPPVQIIPNCEELMVGMLALIE 414
            .|.||..:|...|..|.:|.|  :|...||||...::||...|...|:..:.|
Worm   384 GSEDWAKHEAKVKFVYLLELRPDEKNWDGFILDEKELIPTARETWEGVRVVAE 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18585	NP_001260213.1	Propep_M14	34..105	CDD:280416	17/72 (24%)
CG18585	NP_001260213.1	M14_CP_A-B_like	122..415	CDD:199844	107/311 (34%)
T06A4.3	NP_001021611.1	Propep_M14	31..98	CDD:366995	15/66 (23%)
		M14_CP_A-B_like	128..438	CDD:349433	107/311 (34%)
		ShK	468..505	CDD:366702
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37541
Inparanoid	1	1.050	239	1.000	Inparanoid score	I2114
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47975
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		mtm4737
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.880