Protein Alignment Slob and PXK

DIOPT Version :9

• Sequence 1: NP_001260212.1
• Gene: Slob / 34038
• FlyBaseID: FBgn0264087
• Length: 1347
• Species: Drosophila melanogaster
• Sequence 2: NP_001336421.1
• Gene: PXK / 54899
• HGNCID: 23326
• Length: 581
• Species: Homo sapiens
• Alignment Length: 620
• Identity: 162/620 - (26%)
• Similarity: 252/620 - (40%)
• Gaps: 164/620 - (26%)

  Fly    85 QTPKSVSILVYKT--LNTVFKSSRKI------IVRVCEVASAKKSFTMFKFNKAAQQQRID--NR 139
            :.|.:..:|:..|  |....::|:.:      |:||....|.:.|:.:.:     :....|  |.
Human     5 EKPPAGKVLLDDTVPLTAAIEASQSLQSHTEYIIRVQRGISVENSWQIVR-----RYSDFDLLNN 64

  Fly   140 NSAVTGHDPFVRPPVPEKKVRNIMKK---LHKANGLKRSNSAIEFDVSALTAANRRQIYSRPNIK 201
            :..:.|    :..|:|.||:...|.:   ..:..||:          :.|.......|.|  |.:
Human    65 SLQIAG----LSLPLPPKKLIGNMDREFIAERQKGLQ----------NYLNVITTNHILS--NCE 113

  Fly   202 YQYSALDSGNGIVERSPRERAQREKALNATQEWIQGANGRYEVIAHLDEIGSRHGKNWFLVTDAS 266
            .....||..|.....:       |.||.....:.: :..::||:..|.:||.|..|.:||:...:
Human   114 LVKKFLDPNNYSANYT-------EIALQQVSMFFR-SEPKWEVVEPLKDIGWRIRKKYFLMKIKN 170

  Fly   267 VRTDRLQTLLPLPPDCVAFEDLPPNECAR----EILMELLGSLHHPYIYPVLDLGFLRNSSYNYA 327
            ...:||         .:::.||.|::...    :.|::||.|..|||||.|.    ...::.:.|
Human   171 QPKERL---------VLSWADLGPDKYLSDKDFQCLIKLLPSCLHPYIYRVT----FATANESSA 222

  Fly   328 CLVTPFNSRGSLKDLIYKAQWNEPWARKY--TRKPNGLPVSQVQRLGRQILEALLFLKERGFPLH 390
            .|:..||.:|:||||||||:..:|:.:||  .:|..||.:.|::..||||||.|.||.::||| :
Human   223 LLIRMFNEKGTLKDLIYKAKPKDPFLKKYCNPKKIQGLELQQIKTYGRQILEVLKFLHDKGFP-Y 286

  Fly   391 GHLHSGNVILQNGAARLSGLENGLLGLSSRINAVMWS-RSVTEIENVDIVCFGHLLYEMCTGQ-- 452
            ||||:.||:|.....||..|||.||||.|...:.... |.:..:|:||:.|||||||||..|:
Human   287 GHLHASNVMLDGDTCRLLDLENSLLGLPSFYRSYFSQFRKINTLESVDVHCFGHLLYEMTYGRPP 351

  Fly   453 -----ELTTPKPSMRVLEMELQHYPQIGQILEILGLIFEPPSGVCPSVEDLVLCDLFRSIDLREL 512
                 :...|.|||.|:           .:||.. |..|......|::..|:...||..:.|...
Human   352 DSVPVDSFPPAPSMAVV-----------AVLEST-LSCEACKNGMPTISRLLQMPLFSDVLLTTS 404

  Fly   513 RGPCF---STIKPSL-----------------------------------SRSTLNLLQAVKKRQ 539
            ..|.|   :.:|.:|                                   .|....:|...|.::
Human   405 EKPQFKIPTKLKEALRIAKECIEKRLIEEQKQIHQHRRLTRAQSHHGSEEERKKRKILARKKSKR 469

  Fly   540 CA---SLGHSL----------SEANSPCTPPSTPHDRRT----GISR----------------TM 571
            .|   |..||.          |.|:||.|.||:|....|    |:|:                |.
Human   470 SALENSEEHSAKYSNSNNSAGSGASSPLTSPSSPTPPSTSAALGLSKRCKERDICITSTSSTSTT 534

  Fly   572 DSFDISSDSEEGLLEEIVVGGSCHRQHLLRLQQWH 606
            .|..::|....|....:|.|  |         :||
Human   535 TSSSLASCEHRGTCPALVSG--C---------EWH 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slob	NP_001260212.1	PKc	286..481	CDD:270622	83/208 (40%)
PXK	NP_001336421.1	PX_MONaKA	13..132	CDD:132781	27/146 (18%)
		SPS1	186..492	CDD:223589	98/322 (30%)
		PKc	198..345	CDD:270622	69/151 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6221
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D477171at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.870