Protein Alignment Slob and Sgk3

DIOPT Version :10

• Sequence 1: NP_001260212.1
• Gene: Slob / 34038
• FlyBaseID: FBgn0264087
• Length: 1347
• Species: Drosophila melanogaster
• Sequence 2: NP_001362972.1
• Gene: Sgk3 / 171498
• RGDID: 620242
• Length: 496
• Species: Rattus norvegicus
• Alignment Length: 640
• Identity: 137/640 - (21%)
• Similarity: 212/640 - (33%)
• Gaps: 224/640 - (35%)

  Fly   156 EKKVRNIMKKLHKANGLKRSNSAI-----EFDVSALTAANRRQIYSRPNIKYQYSALDSGNGIVE 215
            |||.|..:.|:..:.|  ||...:     |||          ::|:  ::|.|:.|:      ..
  Rat    26 EKKKRFTVYKVLVSVG--RSEWFVFRRYAEFD----------KLYN--SLKKQFPAM------AL 70

  Fly   216 RSPRER-----------AQREKALNATQEWIQGANGRY-------EVIAHLDEIGSRHGKNWFLV 262
            :.|.:|           .||...||   |:||.. .||       :|.|.|.....||      .
  Rat    71 KIPAKRIFGDNFDPDFIKQRRAGLN---EFIQNL-VRYPELYNHPDVRAFLQMDSPRH------Q 125

  Fly   263 TDASVRTDRLQTLLPLPPDCVAFEDLPPNECAREILMELLGSLHHPYIYPVLDLGFLRNSSYNYA 327
            :|.|...|...|     |        .|:..:|.|   .||...:|:..| .|..||:
  Rat   126 SDPSEDEDERST-----P--------KPHSTSRNI---NLGPTGNPHAKP-SDFDFLK------- 166

  Fly   328 CLVTPFNSRGSL-KDLIYKAQWNEPWARKYTRKPNG--LPVSQVQR---LGRQILEALLFLKERG 386
                 ...:||. |.|:.|            ||.:|  ..|..:|:   |.|:  |....:.||
  Rat   167 -----VIGKGSFGKVLLAK------------RKLDGKFYAVKVLQKKIVLNRK--EQKHIMAER- 211

  Fly   387 FPLHGHLHSGNVILQNGAARLSGLENGLLGLSSRINAVMWSRSVTE--IENVDIVCFGHLLYEMC 449
                      ||:|:|.....      |:||.       :|...||  ...:|.|..|.|.:.:
  Rat   212 ----------NVLLKNVKHPF------LVGLH-------YSFQTTEKLYFVLDFVNGGELFFHL- 252

  Fly   450 TGQELTTPKPSMRVLEMELQHYPQIGQILEILGLIFEPPSGVCPSVEDLVLCDLFRSIDLRELRG 514
             .:|.:.|:|..|....|         |...||.:                    .||.:
  Rat   253 -QRERSFPEPRARFYAAE---------IASALGYL--------------------HSIKI----- 282

  Fly   515 PCFSTIKPSLSRSTLNLLQAVKKRQCASLGHSLSEANSPCTPPSTPHDRRTGISRTMDSFDISSD 579
             .:..:||.      |:|       ..|:||.:......|       .....||.|..:|   ..
  Rat   283 -VYRDLKPE------NIL-------LDSMGHVVLTDFGLC-------KEGIAISDTTTTF---CG 323

  Fly   580 SEEGLLEEIVVGGSCHRQHLLRLQQWHSAHSYVHSYASESPIHYC-DPAAVYSDDNSQEPGQDPQ 643
            :.|.|..|::     .:|.......|....:.::......|..|| |.|.:|  ||...     :
  Rat   324 TPEYLAPEVI-----RKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMY--DNILH-----K 376

  Fly   644 PPTIR--CSTSSQSNLDVLLAE------GAADEVYEEQEEEGFEQEEEASGSSGTQRLQAPACTS 700
            |..:|  .|.::.|.|:.||.:      ||.::..|.|....|   |..|.:...|:...|....
  Rat   377 PLNLRPGVSLTAWSILEELLEKNRQNRLGAKEDFLEIQNHPFF---ESLSWTDLVQKKIPPPFNP 438

  Fly   701 SAAG----ASFNHQLTAD-----MC---NYKNSKSRRLEYSLKCLKYGRSNPSQD 743
            :.||    .:|:...|.:     :|   :|....:..||.....:.:..:.||:|
  Rat   439 NVAGPDDIRNFDAVFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSED 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slob	NP_001260212.1	Protein Kinases, catalytic domain	286..481	CDD:473864	45/202 (22%)
Sgk3	NP_001362972.1	PX_CISK	12..120	CDD:132780	29/117 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..157		13/57 (23%)
		STKc_SGK3	165..490	CDD:270755	89/449 (20%)
		Nuclear localization signal. /evidence=ECO:0000250	195..205		3/11 (27%)