DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6739 and Lrp1b

DIOPT Version :10

Sequence 1:NP_609130.1 Gene:CG6739 / 34037 FlyBaseID:FBgn0031926 Length:787 Species:Drosophila melanogaster
Sequence 2:XP_006498522.1 Gene:Lrp1b / 94217 MGIID:2151136 Length:4668 Species:Mus musculus


Alignment Length:475 Identity:110/475 - (23%)
Similarity:165/475 - (34%) Gaps:152/475 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   349 DSLIRANCSVR---AAEFICGALEPECRPLHI---GQLPPC-----RRICKAILEACSIPIY--- 399
            |:....||...   |.:|.| ....:|.|:::   || ..|     .:.|..  .:|| |.|   
Mouse  3415 DNSDELNCDTHVCLAGQFKC-TKNKKCIPVNLRCNGQ-DDCGDEEDEKDCPE--NSCS-PDYFQC 3474

  Fly   400 --NSDVLGELFDCNLYP---DAHESHKCEDPTRRRDYCYGNEFQCHDGSCIPQNWQCDKIKDCQG 459
              ....:.:|:.|:..|   ||.:...|:..|     |..:||||.:.:|||.:|:||...||..
Mouse  3475 KTTKHCISKLWVCDEDPDCADASDEANCDKKT-----CGPHEFQCKNNNCIPDHWRCDNQNDCSD 3534

  Fly   460 GEDEDEQCLVCEPD-----EFRCRSNEKCLVEKYRCDQNIDCMDGSDEQDCDEYGSGDL------ 513
            ..|||.    |:|.     :|.| ||..|:..::.||...||.|||||::|:...|.|.      
Mouse  3535 NSDEDN----CKPQTCTLKDFLC-SNGDCVSSRFWCDGEFDCADGSDEKNCETSCSKDQFQCSNG 3594

  Fly   514 --------------APFDESELN---AFPRVFTYASFLSPN-----------------ETNDKVY 544
                          ..:.|.|.|   ||| |.:.:.::..:                 :.:|::.
Mouse  3595 QCLSAKWKCDGHEDCKYGEDEKNCEPAFP-VCSSSEYMCASGGCLSASLKCNGEPDCVDGSDEMD 3658

  Fly   545 TYITATTDEDAGTETKFQIHQVAAPAP----------PVNSSAEEGAGGPKGFVNFRDSKEIMMT 599
            ..|....|:       ||....|...|          .|:.|.||..|  :|....||.:  .:.
Mouse  3659 CVIECKEDQ-------FQCKNKAYCIPIRWLCDGIYDCVDGSDEETCG--RGGSICRDDE--FLC 3712

  Fly   600 SDSETKFKY------------SQRANRTSVKFSVSAPTTPAARTSSAIPSSALVQQRERTTSTTT 652
            ::|..|..:            |..|....||| :..||.|....:..|     ..|.|:..:...
Mouse  3713 NNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKF-LCPPTRPYRCRNDRI-----CLQLEKICNGIN 3771

  Fly   653 TSTTTS-----TTTSSITSTPSITSTTLIPINAATSEPNPYEVVTSLGGCPPQELRCVSGKCITV 712
            .....|     :...|:.|.|                            |...|..|.:..||.:
Mouse  3772 DCGDNSDEEHCSGKLSLKSKP----------------------------CKKDEFTCSNRNCIPM 3808

  Fly   713 SQLCDKQIDCPDAADELMCV 732
            ...||...||.|.:||..|:
Mouse  3809 ELQCDSLDDCGDGSDEQGCL 3828

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6739NP_609130.1 CRD_FZ 314..427 CDD:143549 22/96 (23%)
LDLa 432..464 CDD:238060 14/31 (45%)
LDLa 470..505 CDD:238060 16/39 (41%)
LDLa 697..731 CDD:238060 12/33 (36%)
Lrp1bXP_006498522.1 LDLa 63..95 CDD:238060
LDLa 107..140 CDD:197566
FXa_inhibition 194..224 CDD:464251
LY 314..346 CDD:214531
LY 350..392 CDD:214531
LY 394..435 CDD:214531
FXa_inhibition 506..547 CDD:464251
Ldl_recept_b 599..639 CDD:459654
LY 622..661 CDD:214531
LY 668..717 CDD:214531
LY 718..760 CDD:214531
FXa_inhibition 829..864 CDD:464251
LDLa 917..950 CDD:238060
LDLa 957..989 CDD:197566
LDLa 1000..1033 CDD:238060
LDLa 1037..1070 CDD:238060
LDLa 1084..1119 CDD:238060
Ldl_recept_a 1131..1162 CDD:395011
LDLa 1167..1202 CDD:238060
FXa_inhibition 1207..1243 CDD:464251
YncE 1313..1537 CDD:442618
LY 1358..1398 CDD:214531
LY 1402..1445 CDD:214531
Ldl_recept_b 1649..1689 CDD:459654
LY 1672..1714 CDD:214531
Ldl_recept_b 1736..1773 CDD:459654
LY <1766..1797 CDD:214531
FXa_inhibition 1869..1905 CDD:464251
NHL 1944..2169 CDD:302697
NHL repeat 1944..1983 CDD:271320
LY 1978..2018 CDD:214531
NHL repeat 1988..2025 CDD:271320
NHL repeat 2029..2070 CDD:271320
Ldl_recept_b 2039..2080 CDD:459654
LY 2064..2106 CDD:214531
NHL repeat 2073..2111 CDD:271320
NHL repeat 2120..2159 CDD:271320
FXa_inhibition 2178..2213 CDD:464251
Ldl_recept_b 2361..2403 CDD:459654
LY 2386..2428 CDD:214531
LDLa 2545..2574 CDD:238060
LDLa 2583..2617 CDD:238060
LDLa 2622..2656 CDD:238060
LDLa 2676..2705 CDD:238060
LDLa 2713..2747 CDD:238060
LDLa 2751..2784 CDD:238060
LDLa 2791..2824 CDD:197566
LDLa 2875..2908 CDD:197566
LDLa 2922..2956 CDD:238060
FXa_inhibition 2968..2997 CDD:464251
EGF_CA 2999..3033 CDD:214542
LY 3066..3110 CDD:214531
LY 3111..3149 CDD:214531
LY 3154..3195 CDD:214531
LY 3198..3237 CDD:214531
FXa_inhibition 3308..3344 CDD:464251
LDLa 3348..3379 CDD:197566
LDLa 3388..3422 CDD:238060 1/6 (17%)
LDLa 3427..3462 CDD:238060 8/36 (22%)
LDLa 3467..3502 CDD:238060 9/35 (26%)
LDLa 3507..3541 CDD:238060 16/37 (43%)
LDLa 3546..3580 CDD:238060 14/34 (41%)
LDLa 3584..3618 CDD:238060 4/33 (12%)
LDLa 3625..3659 CDD:238060 1/33 (3%)
LDLa 3663..3698 CDD:238060 9/41 (22%)
LDLa 3705..3737 CDD:238060 5/33 (15%)
LDLa 3746..3782 CDD:238060 7/40 (18%)
LDLa 3793..3827 CDD:238060 12/33 (36%)
EGF_CA 3875..3909 CDD:214542
NHL 3972..4204 CDD:302697
NHL repeat 4002..4039 CDD:271320
NHL repeat 4060..4098 CDD:271320
Ldl_recept_b 4070..4111 CDD:459654
LY 4094..4133 CDD:214531
NHL repeat 4148..4186 CDD:271320
EGF_CA 4281..4315 CDD:238011
Blue background indicates that the domain is not in the aligned region.

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