Protein Alignment CG6739 and LRP8

DIOPT Version :9

• Sequence 1: NP_609130.1
• Gene: CG6739 / 34037
• FlyBaseID: FBgn0031926
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: XP_005271230.1
• Gene: LRP8 / 7804
• HGNCID: 6700
• Length: 976
• Species: Homo sapiens
• Alignment Length: 423
• Identity: 94/423 - (22%)
• Similarity: 127/423 - (30%)
• Gaps: 170/423 - (40%)

  Fly   374 PLHIGQLP---------PCRRICKAILEACSIPIYNSDVLGELFDCNLYPDAHESHK--CEDP-- 425
            ||..||.|         .||.      |.|...::..|   |..||..:.|..:..|  |.|.
Human    36 PLLGGQGPAKDCEKDQFQCRN------ERCIPSVWRCD---EDDDCLDHSDEDDCPKKTCADSDF 91

  Fly   426 -------TRRRDYCYGNEFQCHDGS-------------------------CIPQNWQCDKIKDCQ 458
                   ...|..|.|.| :|.|||                         |:|.:|:||..|||:
Human    92 TCDNGHCIHERWKCDGEE-ECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCE 155

  Fly   459 GGEDEDEQCLVCEPDEFRCRSNEKCLVEKYRCDQNIDCMDGSDEQDCDEYGSGDLAPFDESELNA 523
            ||.||.....:|.|.||:| .|..||...:.||.:.||.|||||:.|.:...|
Human   156 GGADEAGCATLCAPHEFQC-GNRSCLAAVFVCDGDDDCGDGSDERGCADPACG------------ 207

  Fly   524 FPRVFTYASFLSPNETNDKVYTYITATTDEDAGTETKFQIHQVAAPAPPVNSSAEEGAGGPKGFV 588
             ||.|....                     |.|                       ||..|:.:|
Human   208 -PREFRCGG---------------------DGG-----------------------GACIPERWV 227

  Fly   589 NFRDSKEIMMTSDSETKFKYSQRANRTSV------KFSVSAPTTPAARTSSAIPSSALVQQRERT 647
                         .:.:|....|::..:.      ..:.|||...|..:..|..|...|....|.
Human   228 -------------CDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRC 279

  Fly   648 TSTTTTSTTTSTTTSSITSTPSITSTTLIPINAATSEPNPYEVVTSLGGCPPQELRCVSGKCITV 712
            .........:.                              |....||.|...|.:|..|.|:..
Human   280 DGDRDCKDKSD------------------------------EADCPLGTCRGDEFQCGDGTCVLA 314

  Fly   713 SQLCDKQIDCPDAADELMCVY--------RERP 737
            .:.|:::.||||.:||..|:.        |.||
Human   315 IKHCNQEQDCPDGSDEAGCLQVPPTFLGNRRRP 347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6739	NP_609130.1	CRD_FZ	314..427	CDD:143549	17/72 (24%)
		LDLa	432..464	CDD:238060	18/56 (32%)
		LDLa	470..505	CDD:238060	17/34 (50%)
		LDLa	697..731	CDD:238060	12/33 (36%)
LRP8	XP_005271230.1	LDLa	47..81	CDD:238060	9/42 (21%)
		LDLa	85..117	CDD:197566	10/32 (31%)
		LDLa	127..163	CDD:238060	12/35 (34%)
		LDLa	206..240	CDD:197566	12/103 (12%)
		Ldl_recept_a	262..294	CDD:278486	5/61 (8%)
		Ldl_recept_a	298..333	CDD:278486	12/34 (35%)
		FXa_inhibition	353..387	CDD:291342
		EGF_CA	389..419	CDD:214542
		LY	458..493	CDD:214531
		LY	502..544	CDD:214531
		Ldl_recept_b	565..605	CDD:278487
		LY	589..631	CDD:214531
		Ldl_recept_b	652..691	CDD:278487
		FXa_inhibition	710..747	CDD:291342

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900