Protein Alignment CG6739 and SORL1

DIOPT Version :10

• Sequence 1: NP_609130.1
• Gene: CG6739 / 34037
• FlyBaseID: FBgn0031926
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_003096.2
• Gene: SORL1 / 6653
• HGNCID: 11185
• Length: 2214
• Species: Homo sapiens
• Alignment Length: 526
• Identity: 127/526 - (24%)
• Similarity: 171/526 - (32%)
• Gaps: 158/526 - (30%)

  Fly   297 RPTEAMALTTPSTTNS-GCQ------STMLP----MCQGVLDYDLTFN----REGAAPRDAVSMA 346
            ||...:.|  |...|| .|:      |::||    ||.....|.|..|    :|....|:....:
Human  1024 RPCSLLCL--PKANNSRSCRCPEDVSSSVLPSGDLMCDCPQGYQLKNNTCVKQENTCLRNQYRCS 1086

  Fly   347 AYDSLIRANC--SVRAAEF--ICGALEPE--CRPLHIGQLPPCRRICKAILEACSIPI-YNSDVL 404
                  ..||  |:...:|  .||.:..|  | |..|..|....| |:.  ....||: |..|:.
Human  1087 ------NGNCINSIWWCDFDNDCGDMSDERNC-PTTICDLDTQFR-CQE--SGTCIPLSYKCDLE 1141

  Fly   405 GELFDCNLYPDAHESH-----------------------KCEDPTRRRDY------------CYG 434
            .   ||.  .::.|||                       .|:.....||:            |..
Human  1142 D---DCG--DNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEA 1201

  Fly   435 NEFQCHDGSCIPQNWQCDKIKDCQGGEDEDEQCLVCEP--DEFRCRSNEKCLVEKYRCDQNIDCM 497
            :.|||.:|.||||.|.||...|||.|.|||.  :.||.  :.||| .|..|:.....||...||.
Human  1202 SNFQCRNGHCIPQRWACDGDTDCQDGSDEDP--VNCEKKCNGFRC-PNGTCIPSSKHCDGLRDCS 1263

  Fly   498 DGSDEQDCDEYGSGDLAPFDESELNAFPRVFTYASFLSPNETNDKVYTYI-------TATTDED- 554
            ||||||.|:                  |....:..|:..|......::.:       ...:|||
Human  1264 DGSDEQHCE------------------PLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDA 1310

  Fly   555 --AGTETKFQIHQVAAPAPPVNSSAEEGAGGPKGFVNFRDSKEIMMTSDSETKFKYSQRANRTSV 617
              ||.....:.|:|.         .|.|.....|..    ...|......:....||..||   .
Human  1311 AFAGCSQDPEFHKVC---------DEFGFQCQNGVC----ISLIWKCDGMDDCGDYSDEAN---C 1359

  Fly   618 KFSVSAPTTP-----AARTSSAIPSSALVQQRERTTSTTTTSTTTSTTTSSITSTPSITSTTLIP 677
            :....||...     .......||:.   .:.:|.......|.......|.|           :|
Human  1360 ENPTEAPNCSRYFQFRCENGHCIPNR---WKCDRENDCGDWSDEKDCGDSHI-----------LP 1410

  Fly   678 INAATSEPNPYEVVTSLGGCPPQELRCVSGKCITVSQLCDKQIDCPDAADELMCVYRERPSRRRL 742
            .    |.|.|       ..|.|...||.||.|:..:.:||...||.|.:||..|     |....:
Human  1411 F----STPGP-------STCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEAC-----PLLANV 1459

  Fly   743 TSTTAP 748
            |:.:.|
Human  1460 TAASTP 1465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6739	NP_609130.1	CRD_FZ	314..427	CDD:143549	34/156 (22%)
		LDLa	432..464	CDD:238060	17/31 (55%)
		LDLa	470..505	CDD:238060	17/36 (47%)
		LDLa	697..731	CDD:238060	14/33 (42%)
SORL1	NP_003096.2	Cell attachment site. /evidence=ECO:0000255	63..65
		VPS10	124..753	CDD:214740
		BNR 1	136..147
		BNR 2	232..243
		BNR 3	441..452
		BNR 4	521..532
		BNR 5	562..573
		LY	780..821	CDD:214531
		LDL-receptor class B 1	800..843
		LY	824..866	CDD:214531
		LDL-receptor class B 2	844..887
		LY	868..910	CDD:214531
		LDL-receptor class B 3	888..932
		Ldl_recept_b	890..929	CDD:459654
		LY	913..953	CDD:214531
		LDL-receptor class B 4	933..970
		LY	953..993	CDD:214531
		LDL-receptor class B 5	971..1013
		LDLa	1078..1112	CDD:238060	8/39 (21%)
		LDLa	1120..1153	CDD:238060	10/40 (25%)
		Ldl_recept_a	1157..1192	CDD:395011	3/34 (9%)
		LDLa	1198..1230	CDD:197566	16/31 (52%)
		LDLa	1240..1271	CDD:238060	15/31 (48%)
		LDLa	1281..1308	CDD:197566	2/26 (8%)
		LDLa	1325..1359	CDD:238060	8/49 (16%)
		LDLa	1373..1403	CDD:238060	4/32 (13%)
		LDLa	1419..1453	CDD:238060	14/33 (42%)
		LDLa	1471..1506	CDD:238060
		LDLa	1513..1546	CDD:197566
		FN3	1557..>1628	CDD:238020
		FN3	1651..1742	CDD:238020
		FN3	1703..>2099	CDD:442628
		FN3	1934..2021	CDD:238020
		Potential nuclear localization signal for the C-terminal fragment generated by PSEN1. /evidence=ECO:0000305|PubMed:16531402	2161..2164
		Endocytosis signal. /evidence=ECO:0000255	2172..2177
		Required for efficient Golgi apparatus -endosome sorting. /evidence=ECO:0000269|PubMed:17646382	2190..2214
		Required for interaction with GGA1 and GGA2. /evidence=ECO:0000269|PubMed:11821067	2201..2214
		DXXLL motif involved in the interaction with GGA1. /evidence=ECO:0000269|PubMed:20015111	2208..2212