Protein Alignment CG6739 and lrp5

DIOPT Version :10

• Sequence 1: NP_609130.1
• Gene: CG6739 / 34037
• FlyBaseID: FBgn0031926
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_001170929.3
• Gene: lrp5 / 568518
• ZFINID: ZDB-GENE-050518-2
• Length: 1615
• Species: Danio rerio
• Alignment Length: 956
• Identity: 172/956 - (17%)
• Similarity: 283/956 - (29%)
• Gaps: 373/956 - (39%)

  Fly     7 LEAIANETSSVTGLRRQ--PTKYPHGLNIT------------VQTID--DDNEGSPKD------- 48
            |:....|::::.||:|:  ....||...:|            :::|:  |...|..:.
Zfish   828 LDTCMIESTNMQGLQREIVADDLPHPFGLTQYRDYIYWTDWNLRSIERADKRSGLNRTVVQGHLE 892

  Fly    49 --------HSDYTRASGDSCWSKTQKYHIGMLGSPETLAELQVRRYKYPLTANYYLNSKLERPEK 105
                    ||.....:.|...:..|..|: .|.||   :..|.|     ..::|.|.:.......
Zfish   893 YVMDILVFHSSRQDGANDCSQNNGQCAHL-CLASP---SGAQCR-----CASHYTLEANGRNCSS 948

  Fly   106 PTPWMLLGYARSVCR----------------WKYLRWPIIFVASVLLFFGLITYCLWLHDVSVAR 154
            |:.::|.....|:.|                .|.||        .:.|..|.....|:.    .|
Zfish   949 PSSFLLFSQKSSISRMVLGEQSPDMILPIHVMKNLR--------AISFDPLERLVYWVD----GR 1001

  Fly   155 AKFLQRRYEATLTSTSSSSNE------------------VWDEETTSSTERSPQETTRLEDMDDS 201
            ....:.|.:.|..||..:.|.                  .|..|||:        |..:..||
Zfish  1002 QNIRRSRDDGTQASTVMTPNSDHPKQPHDLSLDPYSRTVYWTCETTN--------TINIHRMD-- 1056

  Fly   202 DESTELPEIAFGDDGDPEA---GGEDG-------------------DGDYDDTL----------- 233
              ...:.|:...|...|.|   ..|.|                   ||...::|
Zfish  1057 --GHIIGEVLKDDVDKPRAIVVNAEKGYMYFTTVQERSAKIEGASLDGTERESLFTTSLIRPVAL 1119

  Fly   234 -----------LPADSIRFTSGH---------QNS-----FGVP--------IEQDKRMLQLLKE 265
                       :.||..|..|..         |:|     .|:.        |::.::|::.:.:
Zfish  1120 ALDNKLGKLFWVDADLKRIESSDLSGANRIVLQDSNILQPVGLTVLGDHLYWIDKQQQMIERVDK 1184

  Fly   266 LLHKPQATPAGNEPTLTRVSPTLPPPLSASGRPTEAMALTTPSTTNSGCQSTMLPMCQGVLDYDL 330
            |..:.:....|....||.:.       :.....|:..|....|..|.||....:....|
Zfish  1185 LTGEKRTRIQGRLQYLTGIH-------AVQYMETDEFATHPCSRDNGGCSHICIAKGDG------ 1236

  Fly   331 TFNREGAAPRDAVSM--AAYDSLIRA----NCSVRAAEFICGALEPECRPLHIGQLPPCRRICKA 389
                   .||.:..|  ....:|:..    .||  :.:|.|...|.:|       :|...| |..
Zfish  1237 -------TPRCSCPMHLVLLQNLLSCGEPPTCS--SEQFTCATGEIDC-------IPMAWR-CDG 1284

  Fly   390 ILEACSIPIYNSDVLGELFDCNLYPDAHESHKCEDPTRRRDYCYGNEFQCHDGSCIPQNWQCDKI 454
            |.|...    |||.:    :|.:                   |...:|||..|.|:....:|:..
Zfish  1285 IAECAD----NSDEM----NCPI-------------------CSKLQFQCDKGQCVDIQVRCNGE 1322

  Fly   455 KDCQGGEDEDEQCLVCEPDEFRCRSNEKCLVEKYRCDQNIDCMDGSDEQDCD------------- 506
            .||..|.||.:...:|..::||| .|.:|:::|.:||...||.|.|||:.||
Zfish  1323 PDCADGSDEQDCETICLSNQFRC-GNSQCILKKQQCDSFPDCTDESDERFCDFPPPPNDLPRHTS 1386

  Fly   507 ---------------------------------------EYGSGD-------LAPFDESE---LN 522
                                                   ||.||.       :||.:...   ::
Zfish  1387 TIGPVIGIILSVFVMGGMCFVCQRVVCRHYKGPNGGFPHEYISGTPHVPLNFIAPTNSQHGKGIS 1451

  Fly   523 AFPRVFTYASFLSPNETNDKVY--TYIT-ATTDEDAGTETKFQIHQVAAPAPPVNSSAEEGAGGP 584
            ....:.:..|.:..:.:...:|  .::| |::...:.|:..|....:..|..|....:...|
Zfish  1452 CGKSMMSSVSLMGSSSSGAPLYDRNHVTGASSSSSSSTKGAFYPQMLNPPPSPATDRSLYNA--- 1513

  Fly   585 KGFVNFRDSKEIMMTSDSETKFKYSQRANRTSVKFSVSAPTTPAARTSSAIPSSALVQQRERTTS 649
                      |:..:|:|.:    :.|:.|..:...|:.||||.                  :|.
Zfish  1514 ----------EVFYSSNSPS----TTRSYRPYLMRGVAPPTTPC------------------STD 1546

  Fly   650 TTTTSTTTSTTTSSITSTPSITSTTLIPINAATSEPNPYEVVTSLGGCPPQELRCVSGKCITVSQ 714
            ...:..|||...|         :...:.:|   |:.:||.        ||...|         ||
Zfish  1547 VCDSDYTTSRWKS---------NKYYMDLN---SDSDPYP--------PPPTPR---------SQ 1582

  Fly   715 LCDKQIDCPDAADELMCVYRERPSRRRLTSTTAPPTTSSAPPETST 760
            ....:..||.:           ||..|......||     ||...|
Zfish  1583 YMSAEESCPPS-----------PSTERSYFHLCPP-----PPSPCT 1612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6739	NP_609130.1	CRD_FZ	314..427	CDD:143549	21/118 (18%)
		LDLa	432..464	CDD:238060	11/31 (35%)
		LDLa	470..505	CDD:238060	15/34 (44%)
		LDLa	697..731	CDD:238060	7/33 (21%)
lrp5	NP_001170929.3	None