DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6739 and lrp1ba

DIOPT Version :9

Sequence 1:	NP_609130.1	Gene:	CG6739 / 34037	FlyBaseID:	FBgn0031926	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	XP_021325253.1	Gene:	lrp1ba / 565136	ZFINID:	ZDB-GENE-050208-608	Length:	4654	Species:	Danio rerio

Alignment Length:	521	Identity:	116/521 - (22%)
Similarity:	171/521 - (32%)	Gaps:	188/521 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   280 TLTRVSPTLPPPLSASGRPTEAMA-------------LTTP-------STTNSGCQSTMLPMCQG 324
            ||:|...|      :.|:.||.::             |..|       ..||.||....|....|
Zfish  3243 TLSRSHKT------SGGKQTELLSSWQTIRDIQVYHPLRQPDVPKHQCQVTNGGCSHLCLLSPGG 3301

  Fly   325 VLDYDLTFNREGAAPRDAVSMAAYDSLIRANCSVRAAEFICGALEPECRPL--------HIG--- 378
                    ..:.|.|.. ..:|..:....:||:  |::|.||.  .||.|.        ..|
Zfish  3302 --------GYKCACPTH-FYLANDNKTCLSNCT--ASQFRCGT--DECIPFWWKCDTVDDCGDGS 3353

  Fly   379 ---------QLPPCRRICKAILEACSIPIYNSDVLGELFDCNLYPDAHESHKCEDPTRRRDY-CY 433
                     :..|.|..|...|  |::|.:..|  || .||.   |..:...|:      .| |.
Zfish  3354 DEPADCPEFKCQPGRFQCGTGL--CALPPFICD--GE-NDCG---DNSDEANCD------SYICL 3404

  Fly   434 GNEFQC-HDGSCIPQNWQCDKIKDCQGGEDEDEQC--LVCEPDEFRCRSNEKCLVEKYRCDQNID 495
            ..:|:| |...|||.|.:|:...||..||||.: |  ..|.|.:|:|:|...|:.:.:.||::.|
Zfish  3405 SGQFKCTHRQKCIPINLRCNGQDDCGDGEDETD-CPENTCSPSQFQCKSTMHCISKLWVCDEDPD 3468

  Fly   496 CMDGSDEQDCDEY----------------------GSGDLAPFDESELNAFPRVFTYASFLSPNE 538
            |.|||||.:|||.                      |..|.:...:.| |..|......:|:..|
Zfish  3469 CADGSDEANCDEKTCGPHEFRCKDNNCIPDHWRCDGQSDCSDNSDEE-NCKPVTCNSKNFICAN- 3531

  Fly   539 TNDKVYTYITATTDEDAGTETKFQIHQVAAPAPPVNSSAEEGAGGPKGFVNFRDSKEIMMTSDSE 603
             .:.:.:......|.|.                 .::|.|.|.                .:..||
Zfish  3532 -GECISSRFRCDGDFDC-----------------TDNSDERGC----------------ESHCSE 3562

  Fly   604 TKFKYSQRANR--TSVKFSVSAPTTPAARTSSAIPSSALVQQRERTTSTTTTSTTTSTTTSSITS 666
            .:|   |..|.  .|||:....                     :....|.......|...:::|:
Zfish  3563 DQF---QCLNHLCISVKWLCDG---------------------QEDCKTGEDEANCSPANTAMTA 3603

  Fly   667 TPSITSTTLIPINAATSEPNPYEVVTSLGGCPPQELRCVSGKCITVSQLCDKQIDCPDAADELMC 731
            .|:                          .|...|..||.|.|:..:|.||.|.||.|.:||:.|
Zfish  3604 RPT--------------------------ACGLNEYVCVGGGCVLAAQRCDGQNDCADGSDEVDC 3642

  Fly   732 V 732
            :
Zfish  3643 L 3643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6739	NP_609130.1	CRD_FZ	314..427	CDD:143549	29/132 (22%)
		LDLa	432..464	CDD:238060	14/32 (44%)
		LDLa	470..505	CDD:238060	15/34 (44%)
		LDLa	697..731	CDD:238060	15/33 (45%)
lrp1ba	XP_021325253.1	LDLa	30..62	CDD:197566
		LDLa	74..107	CDD:197566
		FXa_inhibition	163..191	CDD:317114
		LY	276..309	CDD:214531
		LY	317..359	CDD:214531
		LY	362..402	CDD:214531
		FXa_inhibition	487..519	CDD:317114
		LY	553..593	CDD:214531
		LY	594..633	CDD:214531
		LY	640..689	CDD:214531
		LY	690..732	CDD:214531
		FXa_inhibition	801..838	CDD:317114
		LDLa	891..924	CDD:238060
		LDLa	974..1007	CDD:238060
		LDLa	1011..1042	CDD:197566
		LDLa	1057..1092	CDD:238060
		LDLa	1104..1135	CDD:238060
		LDLa	1140..1173	CDD:197566
		FXa_inhibition	1180..1216	CDD:317114
		LY	1284..1322	CDD:214531
		LY	1331..1370	CDD:214531
		LY	1375..1418	CDD:214531
		LY	<1430..1463	CDD:214531
		LY	1604..1643	CDD:214531
		LY	1645..1687	CDD:214531
		LY	1689..1728	CDD:214531
		LY	<1739..1770	CDD:214531
		FXa_inhibition	1842..1878	CDD:317114
		NHL	1923..>2095	CDD:302697
		NHL repeat	1923..1956	CDD:271320
		NHL repeat	1961..1996	CDD:271320
		NHL repeat	2002..2040	CDD:271320
		NHL repeat	2043..2084	CDD:271320
		FXa_inhibition	2151..2186	CDD:317114
		LY	2265..2305	CDD:214531
		Ldl_recept_b	2334..2375	CDD:278487
		LY	2359..2401	CDD:214531
		FXa_inhibition	2472..2506	CDD:317114
		LDLa	2518..2547	CDD:238060
		LDLa	2556..2590	CDD:238060
		LDLa	2595..2629	CDD:238060
		LDLa	<2652..2681	CDD:294076
		LDLa	2689..2723	CDD:238060
		LDLa	2727..2758	CDD:238060
		LDLa	2768..2801	CDD:238060
		LDLa	2811..2843	CDD:197566
		LDLa	2852..2884	CDD:197566
		LDLa	2898..2932	CDD:238060
		cEGF	2955..2978	CDD:315355
		EGF_CA	2975..3005	CDD:214542
		LY	3042..3086	CDD:214531
		LY	3088..3125	CDD:214531
		Ldl_recept_b	3149..3189	CDD:278487
		LY	3173..3213	CDD:214531
		FXa_inhibition	3284..3320	CDD:317114	9/44 (20%)
		LDLa	3324..3355	CDD:197566	9/34 (26%)
		LDLa	3364..3398	CDD:238060	12/41 (29%)
		LDLa	3403..3438	CDD:238060	15/35 (43%)
		LDLa	3443..3478	CDD:238060	15/34 (44%)
		LDLa	3483..3517	CDD:238060	3/34 (9%)
		LDLa	3522..3556	CDD:238060	6/52 (12%)
		LDLa	3560..3594	CDD:238060	9/57 (16%)
		LDLa	3608..3642	CDD:238060	15/33 (45%)
		LDLa	3646..3681	CDD:238060
LDLa	3688..3720	CDD:238060
LDLa	3729..3765	CDD:238060
LDLa	3775..3809	CDD:238060
Ldl_recept_b	4051..4091	CDD:278487
LY	4075..4116	CDD:214531
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000