DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6739 and lrp8

DIOPT Version :9

Sequence 1:	NP_609130.1	Gene:	CG6739 / 34037	FlyBaseID:	FBgn0031926	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	XP_005166314.1	Gene:	lrp8 / 557734	ZFINID:	ZDB-GENE-050506-134	Length:	1008	Species:	Danio rerio

Alignment Length:	346	Identity:	84/346 - (24%)
Similarity:	123/346 - (35%)	Gaps:	101/346 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   409 DCNLYPDAHESHKCEDPTRRRDYCYGNEFQCHDGSCIPQNWQCDKIKDCQGGEDE-DEQC--LVC 470
            ||:   |..:...|...|     |...:|.|.:|.|:|..|:||...:|..|.|| |..|  ..|
Zfish    52 DCS---DNSDEENCPKKT-----CATTDFACKNGQCVPGRWRCDGEPECPDGSDEADSACSRQTC 108

  Fly   471 EPDEFRC-RSNEKCLVEKYRCDQNIDCMDGSDEQDCDEYGSGDLAPFDESELNAFPRVFTYASFL 534
            .|::|.| .|..||:...:|||...||.:|:||:.|    :.|.......|.....|:....:|:
Zfish   109 PPEKFDCGGSTSKCVSLSWRCDGERDCENGADEEQC----AADAKACPAKEFQCRNRMCVAPTFV 169

  Fly   535 SPNETNDKVYTYITATTDEDAG---TETKFQIHQVAAPAPPVNSSAEEGAGGPKGFVNFRDSKEI 596
            ...              |:|.|   .|.|.             ::|.....||..| ...||:.|
Zfish   170 CDG--------------DDDCGDRSDEEKC-------------TAATASTCGPHEF-RCNDSECI 206

  Fly   597 ----MMTSDSETKFKYSQRANRTSVKFSVSAPTTPAARTSSAIPSSALVQQRERTTSTTTTSTTT 657
                ....|.:.:.|..:...|.|            .||....|..::.:.|.|
Zfish   207 PTPWSCDGDPDCRDKSDESLERCS------------RRTEPQKPHCSMGEFRCR----------- 248

  Fly   658 STTTSSITSTPSITSTTLIPIN-AATSEPNPYE--------VVTSLGGCPPQELRCVSGKCITVS 713
                          |...|.:| ....:|:..:        |:|    |.|.:.:|..|.||..:
Zfish   249 --------------SGECIHLNWKCDGDPDCKDKSDEANCPVLT----CRPDQFQCGDGSCIHGT 295

  Fly   714 QLCDKQIDCPDAADELMCVYR 734
            :.|:|..||||.:||..||.|
Zfish   296 KQCNKVHDCPDFSDEAGCVNR 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6739	NP_609130.1	CRD_FZ	314..427	CDD:143549	4/17 (24%)
		LDLa	432..464	CDD:238060	13/32 (41%)
		LDLa	470..505	CDD:238060	15/35 (43%)
		LDLa	697..731	CDD:238060	14/33 (42%)
lrp8	XP_005166314.1	LDLa	66..98	CDD:197566	12/36 (33%)
		Ldl_recept_a	107..144	CDD:278486	15/36 (42%)
		Ldl_recept_a	191..224	CDD:278486	8/33 (24%)
		Ldl_recept_a	240..274	CDD:278486	6/58 (10%)
		Ldl_recept_a	278..313	CDD:278486	15/38 (39%)
		LDLa	322..352	CDD:197566
		FXa_inhibition	362..396	CDD:291342
		EGF_CA	398..428	CDD:214542
		LY	463..504	CDD:214531
		LY	511..552	CDD:214531
		Ldl_recept_b	573..613	CDD:278487
		LY	597..639	CDD:214531
		Ldl_recept_b	660..699	CDD:278487
		FXa_inhibition	718..755	CDD:291342
		IgaA	913..>985	CDD:284503
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900