DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6739 and Sspo

DIOPT Version :9

Sequence 1:	NP_609130.1	Gene:	CG6739 / 34037	FlyBaseID:	FBgn0031926	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001007017.1	Gene:	Sspo / 474348	RGDID:	1549716	Length:	5141	Species:	Rattus norvegicus

Alignment Length:	674	Identity:	129/674 - (19%)
Similarity:	176/674 - (26%)	Gaps:	297/674 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 LTSTSSSSNEVWDEETTSSTERSPQETTRLEDMDDSDESTELPEIAFGDDGDPEAGGEDGDGDYD 230
            |.:|......:||..|....:.||....|:..:                     .|..|||...|
  Rat  1118 LLTTRLGLTLLWDGGTRVLVQLSPHFHGRVTGL---------------------CGNFDGDVSND 1161

  Fly   231 DTLLPADSIRFTSGHQNSFGVPIEQDKRMLQLLKEL-LHKPQATPAGNEPTLTRVSPTLPPPLSA 294
                    :|...|              :|:...|| .|..:..|...||      ..||.|.|.
  Rat  1162 --------LRSRQG--------------VLEPTAELTAHSWRLNPLCPEP------GDLPHPCSV 1198

  Fly   295 SGRPTEAMALTTPSTTNSGCQSTMLPM-----------------------------CQGVLDYDL 330
            :....        :...:.|:..:.|:                             |:.:.....
  Rat  1199 NAHRV--------NWARAHCEVILQPIFAPCHTEVPPQQYYEWCVYDACGCDTGGDCECLCSAIA 1255

  Fly   331 TFNREGAAPRDAVSMAAYDSLIRANCSVRAAEFICGA-LEPECRPLHIGQLPPCRRICKAI--LE 392
            |:..|.|..|..|...:.: |....|........||: ..|.|...|    |..|..|:||  :|
  Rat  1256 TYADECARHRHHVRWRSQE-LCPLQCEGGQVYEPCGSTCPPTCHDHH----PELRWHCQAITCVE 1315

  Fly   393 ACSIP---IYNSDVLGELFDC------NLYPDAHESHK-CEDPTRRRDYCYGNEFQCH------- 440
            .|..|   :.:.....||.||      :.:|......| |.:.|     |..:::.|:
  Rat  1316 GCFCPEGTLLHGGTCVELTDCPCEWQGSFFPPGAVLQKDCGNCT-----CQESQWHCNPSGAPCE 1375

  Fly   441 ---------------DGSCIPQNWQCDKIKDCQGGEDEDEQC--LVCEPDEFRCRSNEKCLVEKY 488
                           .|.|:|..|.||...||..|.|| |.|  .||...:..|:|. :||....
  Rat  1376 EMEPGCAEGEALCRESGHCVPLEWLCDNQDDCGDGSDE-EGCDTSVCGEGQMSCQSG-RCLPLSL 1438

  Fly   489 RCDQNIDCMDGSDEQDCDEYGSGDLAPFDESELNAFPRVFTYASFLSPNETNDKVYTYITATTDE 553
            .||...||.||:|||.|       |.
  Rat  1439 ICDGQDDCGDGTDEQGC-------LC--------------------------------------- 1457

  Fly   554 DAGTETKFQIHQVAAPAPPVNSSAEEGAGGPKGFVNFRDSKEIMMTSDSETKFKYSQRANRTSVK 618
                                          |:||:...|.:
  Rat  1458 ------------------------------PQGFLACADGR------------------------ 1468

  Fly   619 FSVSAPTTPAARTSSAIPSSALVQQRERTTSTTTTSTTTSTTTSSITSTPSITSTTLIPINAATS 683
                  ..|.|......|..                                       ::||..
  Rat  1469 ------CLPPALLCDGHPDC---------------------------------------LDAADE 1488

  Fly   684 EPNPYEVVTSLG--GCPPQELRCVSGKCITVSQLCDKQIDCPDAADELMCVYRERPSRRRLTSTT 746
            |       :.||  .|...|:.||.|.||...||||...||||.||       |.|......|..
  Rat  1489 E-------SCLGWVSCTSGEVSCVDGPCIRTIQLCDGVWDCPDGAD-------EGPVHCSSPSLP 1539

  Fly   747 APPTTSSAPPETSTATTTTGPLSS 770
            .||......|.||:..|:..|:.|
  Rat  1540 TPPAGIGQNPSTSSPDTSPSPVGS 1563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6739	NP_609130.1	CRD_FZ	314..427	CDD:143549	30/154 (19%)
		LDLa	432..464	CDD:238060	12/53 (23%)
		LDLa	470..505	CDD:238060	14/34 (41%)
		LDLa	697..731	CDD:238060	17/33 (52%)
Sspo	NP_001007017.1	VWD	192..341	CDD:214566
		C8	393..468	CDD:285899
		TIL	472..527	CDD:280072
		VWD	556..716	CDD:214566
		C8	769..826	CDD:285899
		TIL	830..883	CDD:280072
		VWD	1019..1168	CDD:278521	15/92 (16%)
		C8	1206..1276	CDD:285899	8/70 (11%)
		TIL	1280..1336	CDD:280072	16/59 (27%)
		LDLa	1381..1416	CDD:238060	12/35 (34%)
		LDLa	1421..1455	CDD:238060	14/34 (41%)
		LDLa	1457..1491	CDD:238060	10/178 (6%)
		LDLa	1497..1528	CDD:197566	17/37 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1533..1567		9/31 (29%)
		Ldl_recept_a	1568..1604	CDD:278486
		TSP1	1702..1753	CDD:214559
		TSP1	1758..1812	CDD:214559
		TIL	1822..1873	CDD:280072
		TSP1	1917..1970	CDD:214559
		FA58C	2070..2226	CDD:214572
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2087..2109
		FA58C	<2111..2225	CDD:238014
		LDLa	2236..2270	CDD:238060
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2262..2335
		LDLa	2392..2426	CDD:238060
		LDLa	2449..2483	CDD:238060
		TSP1	2490..2538	CDD:214559
		TSP1	2543..2595	CDD:214559
		TIL	2618..2660	CDD:280072
		TSP1	2703..2752	CDD:214559
		TSP1	2760..2813	CDD:214559
		TSP_1	2819..2867	CDD:278517
		TIL	2871..2930	CDD:280072
		VWC_out	2932..2979	CDD:214565
		TSP1	2972..3023	CDD:214559
		TIL	3075..3127	CDD:280072
		TSP1	3240..3292	CDD:214559
		TIL	3300..3350	CDD:280072
		TSP1	3396..3439	CDD:214559
		TSP1	3460..3504	CDD:214559
		TIL	3514..3570	CDD:280072
		TSP1	3633..3677	CDD:214559
		TSP1	3810..3862	CDD:214559
		TSP1	3879..3927	CDD:214559
		TSP1	3945..3998	CDD:214559
		TSP1	4003..4055	CDD:214559
		TIL	4058..4113	CDD:280072
		TSP1	4158..4208	CDD:214559
		TSP1	4252..4303	CDD:214559
		TSP1	4367..4418	CDD:214559
		TIL	4422..4477	CDD:280072
		TSP1	4611..4659	CDD:214559
		TIL	4673..4719	CDD:280072
		TSP1	4763..4812	CDD:214559
		TIL	4814..4868	CDD:280072
		TIL	4920..4978	CDD:280072
		VWC	4980..5035	CDD:302663
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900