DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6739 and ImpE1

DIOPT Version :9

Sequence 1:	NP_609130.1	Gene:	CG6739 / 34037	FlyBaseID:	FBgn0031926	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001261577.1	Gene:	ImpE1 / 45879	FlyBaseID:	FBgn0001253	Length:	1616	Species:	Drosophila melanogaster

Alignment Length:	470	Identity:	113/470 - (24%)
Similarity:	154/470 - (32%)	Gaps:	143/470 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 TERSPQETT--RLEDMDDSDESTELP-EIAFG--DDGDPEAGGE--------------DGDGDYD 230
            ||..|:|.|  :.::.:..:.:|.|| |:.|.  |..|.....|              ||..:.|
  Fly  1197 TESLPEEATTEKFQEPEPEEVNTPLPEELPFDLTDHSDVNRFNELQSESLILESTTNIDGLQELD 1261

  Fly   231 D------------------TLLPADSIRFTSGHQNSFGVPIEQDKRMLQLLKELLHKPQATPAGN 277
            :                  |..|||.:..|:             :.||.|...:.....|.|...
  Fly  1262 NNHIEEEEPAAHAIPHEEATPNPADIVEITT-------------QTMLGLASRVTLMEPAAPVVT 1313

  Fly   278 E--PTLTRVSPTLPPPLSASGRPTEAMALTTPST-----TNSGCQSTMLPM-------CQGVLDY 328
            .  |.:|...|| |.|:|.:..|:.::|...|.|     .:.|.::..|.:       || :.|.
  Fly  1314 TLMPLMTADEPT-PEPVSPAAIPSASLAAIKPGTELRKRVDLGLEAVSLGLACSSDRQCQ-LADP 1376

  Fly   329 DLTFNREGAAPRDAVSMAAYDSLIRANCSVRAAEFICGALEPECRPLHIGQLPPCRR--ICKAIL 391
            ....||.|.                .:|:.......|.|....|.|   |.. .||.  :|.:..
  Fly  1377 HTVCNRRGV----------------CDCAAGEEGSQCSAERTGCSP---GTF-QCRSSGVCISWF 1421

  Fly   392 EACSIPIYNSDVLGELFDCNLYPDAHESHKCEDPTRRRDYCYGNEFQC-HDGSCIPQNWQCDKIK 455
            ..|.         |.. |||   ||.: .:|....|....|....|:| ..|.||.:...||..:
  Fly  1422 FVCD---------GRA-DCN---DASD-EECTHNARLNQTCPTESFRCQRSGRCISRAALCDGRR 1472

  Fly   456 DCQGGEDEDEQCLVCE---------PDE-FRCRSNEKCLVEKYRCDQNIDCMDGSDEQD--CDEY 508
            .|..||||    |.|:         |:. |||.|.| ||.|...|:..:.|.|||||..  |
  Fly  1473 QCPHGEDE----LGCDGSVKGGNACPEHTFRCGSGE-CLPEYEYCNAIVSCKDGSDEPPHLC--- 1529

  Fly   509 GSGDLAPFDESELNAFPRVFTYASFLSPNETNDKVY------------TYITATTDEDAGTETKF 561
            ||..|.       |.|.|:......|.........|            |.|..:..:..|..|..
  Fly  1530 GSRALP-------NLFMRLIEAGGLLGGGRREADAYCPHRCSNGLCRSTAIVCSGRDGCGDGTDE 1587

  Fly   562 QIHQVA-APAPPVNS 575
            |...|. .|||...|
  Fly  1588 QTCSVCRCPAPTAAS 1602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6739	NP_609130.1	CRD_FZ	314..427	CDD:143549	24/121 (20%)
		LDLa	432..464	CDD:238060	12/32 (38%)
		LDLa	470..505	CDD:238060	17/46 (37%)
		LDLa	697..731	CDD:238060
ImpE1	NP_001261577.1	EB	75..131	CDD:279949
		LDLa	1404..1437	CDD:238060	13/50 (26%)
		LDLa	1448..1483	CDD:238060	14/38 (37%)
		LDLa	1493..1524	CDD:238060	14/31 (45%)
		LDLa	1561..1590	CDD:238060	5/28 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900