Protein Alignment CG6739 and LRP4

DIOPT Version :10

• Sequence 1: NP_609130.1
• Gene: CG6739 / 34037
• FlyBaseID: FBgn0031926
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_002325.2
• Gene: LRP4 / 4038
• HGNCID: 6696
• Length: 1905
• Species: Homo sapiens
• Alignment Length: 425
• Identity: 88/425 - (20%)
• Similarity: 134/425 - (31%)
• Gaps: 171/425 - (40%)

  Fly   337 AAPRDAVSMAAYDSLIRA--NCSVRAAEFIC-------------GALEPECRPLHIGQLPPCRRI 386
            ::|..|...:.:...:.|  .|:...|::.|             |.:.|.|.||..
Human    21 SSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDF--------- 76

  Fly   387 CKAILEACSIPIYNSDVLGELFDCNLYPDAHESHKCEDPTRRRD----YCYGNEFQCHDGSCIPQ 447
                  .|.    |...:...:.|:      ..:.|||.:..:|    .|..:||.|.:|.||..
Human    77 ------HCD----NGKCIRRSWVCD------GDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRS 125

  Fly   448 NWQCDKIKDCQGGEDEDEQCLV--CEPDEFRCRSNEKCLVEKYRCDQNIDCMDGSDEQDCDEYGS 510
            .|.||...||  |::.||||.:  |...|||| |:..|:.|.:.||.:.||.|||||::|..
Human   126 LWHCDGDNDC--GDNSDEQCDMRKCSDKEFRC-SDGSCIAEHWYCDGDTDCKDGSDEENCPS--- 184

  Fly   511 GDLAPFDESELNAFPRVFTYASFLSPNETNDKVYTYITATTDEDAGTETKFQIHQVAAPAPPVNS 575
                                                                    |.||||.|.
Human   185 --------------------------------------------------------AVPAPPCNL 193

  Fly   576 SAEEGAGGPKGFVNFRDSKEIMMTSDSETKFKYSQRANRTSVKFSVSAPTTPAARTSSAIPSSAL 640
            ...:.|.|       |...:|......:....:|..::.:|.:         ..|:...:..|.|
Human   194 EEFQCAYG-------RCILDIYHCDGDDDCGDWSDESDCSSHQ---------PCRSGEFMCDSGL 242

  Fly   641 VQQRERTTSTTTTSTTTSTTTSSITSTPSITSTTLIPINA---------ATSEPNPYEVVTSLGG 696
            .                                    |||         ...:.:.....||:
Human   243 C------------------------------------INAGWRCDGDADCDDQSDERNCTTSM-- 269

  Fly   697 CPPQELRCVSGKCITVSQLCDKQIDCPDAADELMC 731
            |..::.||.||:|:.:|..||.:.||.|.:||..|
Human   270 CTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENC 304

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6739	NP_609130.1	CRD_FZ	314..427	CDD:143549	17/104 (16%)
		LDLa	432..464	CDD:238060	13/31 (42%)
		LDLa	470..505	CDD:238060	17/34 (50%)
		LDLa	697..731	CDD:238060	14/33 (42%)
LRP4	NP_002325.2	LDLa	27..66	CDD:238060	4/38 (11%)
		Ldl_recept_a	70..105	CDD:395011	9/59 (15%)
		LDLa	110..142	CDD:238060	14/33 (42%)
		LDLa	148..182	CDD:238060	17/34 (50%)
		LDLa	231..265	CDD:238060	6/69 (9%)
		LDLa	270..304	CDD:238060	14/33 (42%)
		LDLa	311..343	CDD:197566
		FXa_inhibition	358..393	CDD:464251
		EGF_CA	395..434	CDD:214542
		LY	460..502	CDD:214531
		LDL-receptor class B 1	480..522
		LY	505..545	CDD:214531
		LDL-receptor class B 2	523..565
		LDL-receptor class B 3	566..609
		Ldl_recept_b	566..607	CDD:459654
		LY	590..632	CDD:214531
		LDL-receptor class B 4	610..652
		LY	633..673	CDD:214531
		LDL-receptor class B 5	653..693
		FXa_inhibition	702..>729	CDD:464251
		YncE	749..982	CDD:442618
		LDL-receptor class B 6	785..827
		LY	808..850	CDD:214531
		LDL-receptor class B 7	828..870
		LDL-receptor class B 8	871..914
		Ldl_recept_b	871..912	CDD:459654
		LY	895..937	CDD:214531
		LDL-receptor class B 9	915..956
		LDL-receptor class B 10	957..998
		FXa_inhibition	1006..1043	CDD:464251
		NHL	<1085..1277	CDD:302697
		NHL repeat	1085..1123	CDD:271320
		LDL-receptor class B 11	1093..1135
		NHL repeat	1128..1161	CDD:271320
		LDL-receptor class B 12	1136..1178
		NHL repeat	1166..1203	CDD:271320
		LDL-receptor class B 13	1179..1222
		Ldl_recept_b	1179..1219	CDD:459654
		NHL repeat	1212..1244	CDD:271320
		LDL-receptor class B 14	1223..1263
		NHL repeat	1253..1277	CDD:271320
		LDL-receptor class B 15	1264..1306
		FXa_inhibition	1313..1348	CDD:464251
		Vgb	1332..1583	CDD:443399
		LDL-receptor class B 16	1397..1439
		LDL-receptor class B 17	1440..1482
		LDL-receptor class B 18	1483..1526
		LDL-receptor class B 19	1527..1568
		LDL-receptor class B 20	1569..1610
		FXa_inhibition	1617..1648	CDD:464251
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1659..1686
		Endocytosis signal. /evidence=ECO:0000255	1766..1769
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1852..1905