DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6739 and LRP3

DIOPT Version :9

Sequence 1:	NP_609130.1	Gene:	CG6739 / 34037	FlyBaseID:	FBgn0031926	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	XP_005259002.1	Gene:	LRP3 / 4037	HGNCID:	6695	Length:	785	Species:	Homo sapiens

Alignment Length:	338	Identity:	84/338 - (24%)
Similarity:	119/338 - (35%)	Gaps:	89/338 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   432 CYGNEFQCHDGSCIPQNWQCDKIKDCQGGEDEDEQC---------LVCEPDEFRCRS--NEKCLV 485
            |..:||:|.:|.|:|..|||:.:.:|..|.||. .|         .:|....|.|..  :.:||.
Human   166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEG-NCSAPASEPPGSLCPGGTFPCSGARSTRCLP 229

  Fly   486 EKYRCDQNIDCMDGSDEQDCDEYGSGDLAPFDESELNAFPRVFTYASFLSPN------ETNDKVY 544
            .:.|||...||.|||||..|.:...|       ..|.:|     |.||.||:      ..:|...
Human   230 VERRCDGLQDCGDGSDEAGCPDLACG-------RRLGSF-----YGSFASPDLFGAARGPSDLHC 282

  Fly   545 TYITATTDE---------DAGTETKFQIHQVAAPAPPVNSSAEEGAGGPKGFVNFRDSKEIMMTS 600
            |::..|.|.         ..|.:...|::              ||.|        .....::.|
Human   283 TWLVDTQDSRRVLLQLELRLGYDDYVQVY--------------EGLG--------ERGDRLLQT- 324

  Fly   601 DSETKFKYSQRANRTSVKF-SVSAPTTPA--ARTSSAIPS-SALVQQR------ERTTSTTTTST 655
                   .|.|:|...|.. :.....|.|  ||..||... :|..|.:      |:...:::.|.
Human   325 -------LSYRSNHRPVSLEAAQGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSD 382

  Fly   656 TTSTTTSSITSTPSITSTTLIPINAATSEPNPYEVVTSLGGCPPQELRCV--SGKCITVSQLCDK 718
            ..|.......|.|..........:....:..|        .|||.:..|.  ||.|.|.:..|:.
Human   383 GGSLGDQGCFSEPQRCDGWWHCASGRDEQGCP--------ACPPDQYPCEGGSGLCYTPADRCNN 439

  Fly   719 QIDCPDAADELMC 731
            |..|||.|||..|
Human   440 QKSCPDGADEKNC 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6739	NP_609130.1	CRD_FZ	314..427	CDD:143549
		LDLa	432..464	CDD:238060	13/31 (42%)
		LDLa	470..505	CDD:238060	15/36 (42%)
		LDLa	697..731	CDD:238060	16/35 (46%)
LRP3	XP_005259002.1	CUB	43..156	CDD:238001
		LDLa	166..200	CDD:238060	14/34 (41%)
		LDLa	212..249	CDD:238060	15/36 (42%)
		CUB	254..364	CDD:238001	29/151 (19%)
		LDLa	416..452	CDD:238060	16/35 (46%)
		LDLa	455..489	CDD:238060
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900