DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6739 and ldlra

DIOPT Version :9

Sequence 1:	NP_609130.1	Gene:	CG6739 / 34037	FlyBaseID:	FBgn0031926	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001025454.1	Gene:	ldlra / 387529	ZFINID:	ZDB-GENE-031217-1	Length:	911	Species:	Danio rerio

Alignment Length:	347	Identity:	80/347 - (23%)
Similarity:	115/347 - (33%)	Gaps:	122/347 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   432 CYGNEFQCHDGSCIPQNWQCDKIKDCQGGEDE-DEQCL--VCEPDEFRC--RSNEKCLVEKYRCD 491
            |...::||.:|.||...|.||:..||..|.|| ...||  .|.|.:|.|  |.|: |:.:.::||
Zfish    24 CDSRQYQCGNGKCITARWVCDETDDCGDGTDELPAACLAKTCRPSQFSCGGRLNQ-CIPKSWKCD 87

  Fly   492 QNIDCMDGSDEQDCD-------EY--GSGDLAPFDESELNAFPRVFTYASFLSPNETNDKVYTYI 547
            ...||.:.:||:.||       |:  |||....               |:|:..:|
Zfish    88 GKADCENNADEEGCDPRQCHDGEFRCGSGQCVT---------------AAFVCDDE--------- 128

  Fly   548 TATTDEDAGTETKFQIHQVAAPAPPVNSSAEEGAGGPKGFVNFRDSKEIMMTSDSETKFKYSQRA 612
               .|.:.|::      :|:.|.....||                                |.|.
Zfish   129 ---IDCEDGSD------EVSCPPTTCGSS--------------------------------SFRC 152

  Fly   613 NRTSV--KFSVSAPTTPAARTSSAIPSSALVQQRERTTSTTTTSTTTSTTTSSITSTPSITSTTL 675
            |....  :..|.......|..|..:|...                      ...||.|:....|.
Zfish   153 NNAQCVPRLWVCDGDADCADNSDELPEKC----------------------GPGTSKPTKNPCTS 195

  Fly   676 IPINAATSE---------------PNPYEVVTSLGGCPPQELRCVSGKCITVSQLCDKQIDCPDA 725
            :..:..:.|               .:..|...||..|.|.|.:|..|.||..|:.|:...||.|.
Zfish   196 MEFHCGSGECIHGSWKCDGGADCLDHSDEQNCSLPTCRPDEFQCGDGSCIHGSRQCNHVYDCKDM 260

  Fly   726 ADELMCV---YRERPSRRRLTS 744
            :|||.||   :.|.|.|.:..|
Zfish   261 SDELGCVNATHCEPPYRFKCRS 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6739	NP_609130.1	CRD_FZ	314..427	CDD:143549
		LDLa	432..464	CDD:238060	14/32 (44%)
		LDLa	470..505	CDD:238060	13/36 (36%)
		LDLa	697..731	CDD:238060	15/33 (45%)
ldlra	NP_001025454.1	LDLa	23..55	CDD:197566	12/30 (40%)
		Ldl_recept_a	63..101	CDD:365841	13/38 (34%)
		LDLa	106..140	CDD:238060	10/66 (15%)
		LDLa	144..176	CDD:197566	8/63 (13%)
		Ldl_recept_a	192..227	CDD:365841	3/34 (9%)
		Ldl_recept_a	231..266	CDD:365841	15/34 (44%)
		LDLa	274..304	CDD:238060	3/9 (33%)
		FXa_inhibition	314..348	CDD:373209
		EGF_CA	350..380	CDD:214542
		Ldl_recept_b	437..481	CDD:278487
		Ldl_recept_b	485..525	CDD:278487
		LY	510..551	CDD:214531
		Ldl_recept_b	572..611	CDD:278487
		FXa_inhibition	623..664	CDD:373209
		PHA03247	<666..808	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900