DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6739 and Lrp8

DIOPT Version :9

Sequence 1:	NP_609130.1	Gene:	CG6739 / 34037	FlyBaseID:	FBgn0031926	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	XP_006238632.1	Gene:	Lrp8 / 362558	RGDID:	1305729	Length:	1013	Species:	Rattus norvegicus

Alignment Length:	459	Identity:	102/459 - (22%)
Similarity:	141/459 - (30%)	Gaps:	202/459 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   374 PLHIGQLP---------PCRRICKAILEACSIPIYNSDVLGELFDCNLYPDAHESHK--CED--- 424
            ||..||.|         .||.      |.|...::..|   |..||:...|..:..|  |.|
  Rat    33 PLPGGQGPVKECEEDQFRCRN------ERCIPSVWRCD---EDNDCSDNSDEDDCPKRTCTDSDF 88

  Fly   425 --------PTRRRDYCYGNEFQCHDGS-------------------------CIPQNWQCDKIKD 456
                    |.|.:  |.|.| :|.|||                         |:|.:|:||..||
  Rat    89 TCDNGHCIPERWK--CDGEE-ECPDGSDESKATCSSEECPAEKLSCGPTSHKCVPASWRCDGEKD 150

  Fly   457 CQGGEDEDEQCLVCEPDEFRCRSNEKCLVEKYRCDQNIDCMDGSDEQDCDEYGSGDLAPFDESEL 521
            |:||.||.....:|.|.||:| ||..||...:.||.:.||.|||||:.|    |....|
  Rat   151 CEGGADEAGCPTLCAPHEFQC-SNRSCLASVFVCDGDDDCGDGSDERGC----SDPACP------ 204

  Fly   522 NAFPRVFTYASFLSPNETNDKVYTYITATTDEDAGTETKFQIHQVAAPAPPVNSSAEEGAGG--- 583
               ||.|..                                                 |.||
  Rat   205 ---PREFRC-------------------------------------------------GGGGTCI 217

  Fly   584 PKGFVNFRDSKEIMMTSDSETKFKYSQRANRTSV---KFSVSAPTTPAARTSSAIPSSALVQQRE 645
            |:.:|             .:.:|....|::..:.   :.......||||
  Rat   218 PERWV-------------CDGQFDCEDRSDEAAELCGRAGQGTTATPAA---------------- 253

  Fly   646 RTTSTTTTSTTTS------------------TTTSSITSTPSI---------TSTTLIPINAATS 683
              .:.||..|..|                  .:..:..|.|..         ..|.::.|.....
  Rat   254 --CAPTTQFTCRSGECIHLGWRCDGDRDCKDKSDEADCSAPGPCRENDFQCGDGTCILAIKRCNQ 316

  Fly   684 EPNPYEVVTSLGGC-------PPQELRCVSGKCITVSQLCDKQIDCPDAADE--LMCV------Y 733
            |.:..: .:...||       .|:..:|.||:|:...::||.|.||.|.:||  .:||      .
  Rat   317 ERDCLD-GSDEAGCLQESTCEGPRRFQCKSGECVDGGKVCDDQRDCRDWSDEPQKVCVAPIFQGN 380

  Fly   734 RERP 737
            |.||
  Rat   381 RRRP 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6739	NP_609130.1	CRD_FZ	314..427	CDD:143549	18/74 (24%)
		LDLa	432..464	CDD:238060	18/56 (32%)
		LDLa	470..505	CDD:238060	18/34 (53%)
		LDLa	697..731	CDD:238060	14/42 (33%)
Lrp8	XP_006238632.1	LDLa	44..78	CDD:238060	9/42 (21%)
		LDLa	82..114	CDD:197566	11/34 (32%)
		LDLa	124..160	CDD:238060	12/35 (34%)
		LDLa	203..235	CDD:197566	11/102 (11%)
		LDLa	256..289	CDD:238060	4/32 (13%)
		LDLa	295..329	CDD:238060	3/34 (9%)
		LDLa	333..369	CDD:294076	13/35 (37%)
		FXa_inhibition	390..424	CDD:291342
		EGF_CA	426..456	CDD:214542
		LY	495..530	CDD:214531
		LY	540..581	CDD:214531
		Ldl_recept_b	602..642	CDD:278487
		LY	626..668	CDD:214531
		Ldl_recept_b	689..728	CDD:278487
		FXa_inhibition	747..784	CDD:291342
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900