DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6739 and Lrp4

DIOPT Version :9

Sequence 1:	NP_609130.1	Gene:	CG6739 / 34037	FlyBaseID:	FBgn0031926	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_727914.1	Gene:	Lrp4 / 32552	FlyBaseID:	FBgn0030706	Length:	2009	Species:	Drosophila melanogaster

Alignment Length:	315	Identity:	84/315 - (26%)
Similarity:	125/315 - (39%)	Gaps:	71/315 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   355 NCSVRAAEFICGALEPECRPLHIGQLPPCRRICKAILEACSIPIYNSDVLGELFDCNLYPDAHES 419
            :|:..:.|..|.|:...|        |.....|:..|.....|  :...:...|.|:...|..:.
  Fly   330 DCNDNSDELKCAAVINSC--------PEGEFKCRGGLGGAGGP--SGQCILNRFRCDGDNDCGDW 384

  Fly   420 HKCEDPTRRRDYCYGNEFQCHDGSCIPQNWQCDKIKDCQGGEDED-------EQCLVCEPDEFRC 477
            ...|:..::...|..||::|.||:|||:.|:|||.:||.|||||:       |..|.|..|||.|
  Fly   385 SDEENCPQKPSLCTSNEYKCADGTCIPKRWKCDKEQDCDGGEDENDCGSLGSEHPLTCGSDEFTC 449

  Fly   478 RSNEKCLVEKYRCDQNIDCMDGSDEQDCDEYGSGDLAPFDESELNAFPRVFTYASFLSP---NET 539
             :|.:|:::.:.||...||..|.||.:|  :...||                 ..||.|   |.|
  Fly   450 -NNGRCILKTWLCDGYPDCAAGEDEVEC--HLQCDL-----------------GQFLCPTKQNLT 494

  Fly   540 NDKV----------YTYITATTDE-DAGTETKFQIHQVAAPAPPVNSSAEEGAGGPK-----GFV 588
            |.|:          :....|..|| |...|.|     .:.|:|......|..||..:     |:|
  Fly   495 NLKICVHQKHICDGHNECPAGEDEADCPKERK-----CSEPSPCEQLCIETTAGSNECACRLGYV 554

  Fly   589 NFRDSKEIMMTSDSETKF----KYSQRANRTSVKFSVSAPT----TPAARTSSAI 635
              .|..::..|...|.::    ..||:.:.|...|..|..|    .|..|:..|:
  Fly   555 --MDKNKVNCTDIDECQYLTSPVCSQKCHNTMGSFKCSCETGYILRPDLRSCKAL 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6739	NP_609130.1	CRD_FZ	314..427	CDD:143549	13/71 (18%)
		LDLa	432..464	CDD:238060	19/31 (61%)
		LDLa	470..505	CDD:238060	14/34 (41%)
		LDLa	697..731	CDD:238060
Lrp4	NP_727914.1	LDLa	267..301	CDD:238060
		LDLa	306..340	CDD:238060	2/9 (22%)
		LDLa	347..390	CDD:238060	9/52 (17%)
		LDLa	397..431	CDD:238060	20/33 (61%)
		LDLa	442..476	CDD:238060	14/34 (41%)
		LDLa	480..521	CDD:238060	12/57 (21%)
		FXa_inhibition	576..604	CDD:291342	8/27 (30%)
		LY	634..671	CDD:214531
		NHL	<656..793	CDD:302697
		LY	680..714	CDD:214531
		NHL repeat	681..722	CDD:271320
		NHL repeat	726..760	CDD:271320
		LY	761..803	CDD:214531
		NHL repeat	769..793	CDD:271320
		FXa_inhibition	882..912	CDD:291342
		LY	946..985	CDD:214531
		NHL	<967..1142	CDD:302697
		LY	988..1030	CDD:214531
		NHL repeat	998..1037	CDD:271320
		NHL repeat	1038..1080	CDD:271320
		NHL repeat	1084..1119	CDD:271320
		FXa_inhibition	1185..1220	CDD:291342
		NHL	1260..>1445	CDD:302697
		NHL repeat	1260..1296	CDD:271320
		NHL repeat	1302..1337	CDD:271320
		NHL repeat	1345..1383	CDD:271320
		FXa_inhibition	<1499..1525	CDD:291342
		LY	1600..1640	CDD:214531
		LY	1643..1686	CDD:214531
		LY	1688..1729	CDD:214531
		FXa_inhibition	1801..>1825	CDD:291342
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24270
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.000