DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6739 and Lrp6

DIOPT Version :9

Sequence 1:NP_609130.1 Gene:CG6739 / 34037 FlyBaseID:FBgn0031926 Length:787 Species:Drosophila melanogaster
Sequence 2:XP_017448147.1 Gene:Lrp6 / 312781 RGDID:1304749 Length:1613 Species:Rattus norvegicus


Alignment Length:429 Identity:98/429 - (22%)
Similarity:139/429 - (32%) Gaps:140/429 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   349 DSLIRANCSVRAA----EFICGALEPECRPLHIGQLPPCRRICKAILEACSIPIYNSDVLGELFD 409
            |...|.:|.:...    |..||. .|.|.|...               .|    :..|:     |
  Rat  1223 DGTTRCSCPMHLVLLQDELSCGE-PPTCSPQQF---------------TC----FTGDI-----D 1262

  Fly   410 CNLYPDAHESHKCEDPTRRRDY--------CYGNEFQCHDGSCIPQNWQCDKIKDCQGGEDEDEQ 466
            |  .|.|   .:|:..|...|:        |..::|||..|.||....:|:...:||...||...
  Rat  1263 C--IPVA---WRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1322

  Fly   467 CLVCEPDEFRCRSNEKCLVEKYRCDQNIDCMDGSDEQDCDEYGSGDLAPFDESELNAFPRV---- 527
            .::|..|:||| :|.:|:.:..:||.|:||.|.|||.||  |.:.:.||...:.:.:...|    
  Rat  1323 EVLCLIDQFRC-ANGQCVGKHKKCDHNVDCSDRSDELDC--YPTEEPAPQATNTVGSVIGVIVTI 1384

  Fly   528 -------FTYASFLSPNETNDKVYTYITATTDEDAGTETKFQIHQVAA------PAPPVNSSAEE 579
                   |.....|.|....|..    |.|.|        :.:|..|:      |.|...|.:..
  Rat  1385 FVSGTIYFICQRMLCPRMKGDGE----TMTND--------YVVHGPASVPLGYVPHPSSLSGSLP 1437

  Fly   580 GAGGPKGFVNFRDSKEIM-----------------MTSDSETK---------------------- 605
            |....|..::   |..||                 .:|.|.||                      
  Rat  1438 GMSRGKSMIS---SLSIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATERSHYT 1499

  Fly   606 --FKYSQRANRTSVKFS--------VSAPTTPAARTSSAIPSSALVQQRERTTSTTTTSTTTSTT 660
              |.||..:..|...:|        .:.||||.   |:.:..|.....|..|:..|....|:...
  Rat  1500 MEFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPC---STDVCDSDYAPSRRMTSVATAKGYTSDLN 1561

  Fly   661 TSSITSTPSITSTTLIPINAATSEPNPYEVVTSLGGCPP 699
            ..|....|..|     |.:...|....||      .|||
  Rat  1562 YDSEPVPPPPT-----PRSQYLSAEENYE------SCPP 1589

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6739NP_609130.1 CRD_FZ 314..427 CDD:143549 16/81 (20%)
LDLa 432..464 CDD:238060 11/31 (35%)
LDLa 470..505 CDD:238060 16/34 (47%)
LDLa 697..731 CDD:238060 3/3 (100%)
Lrp6XP_017448147.1 NHL 55..272 CDD:302697
NHL repeat 55..93 CDD:271320
LY 89..127 CDD:214531
NHL repeat 97..132 CDD:271320
NHL repeat 140..176 CDD:271320
Ldl_recept_b 150..190 CDD:278487
LY 175..216 CDD:214531
NHL repeat 181..217 CDD:271320
NHL repeat 226..253 CDD:271320
FXa_inhibition 286..323 CDD:291342
LY 353..393 CDD:214531
LY 397..437 CDD:214531
LY 438..481 CDD:214531
LY 483..524 CDD:214531
LY 525..558 CDD:214531
FXa_inhibition 592..627 CDD:291342
LY 656..694 CDD:214531
LY 697..739 CDD:214531
LY 740..783 CDD:214531
LY 783..825 CDD:214531
LY 827..866 CDD:214531
FXa_inhibition 893..929 CDD:291342
LY 958..998 CDD:214531
LY 1001..1048 CDD:214531
Ldl_recept_b 1069..1110 CDD:278487
LY 1094..1136 CDD:214531
FXa_inhibition 1207..1243 CDD:291342 4/19 (21%)
LDLa 1249..1285 CDD:238060 11/64 (17%)
LDLa 1288..1322 CDD:238060 12/33 (36%)
LDLa 1326..1360 CDD:238060 16/34 (47%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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