Protein Alignment CG6739 and Ldlr

DIOPT Version :10

• Sequence 1: NP_609130.1
• Gene: CG6739 / 34037
• FlyBaseID: FBgn0031926
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_786938.2
• Gene: Ldlr / 300438
• RGDID: 2998
• Length: 879
• Species: Rattus norvegicus
• Alignment Length: 324
• Identity: 80/324 - (24%)
• Similarity: 111/324 - (34%)
• Gaps: 97/324 - (29%)

  Fly   430 DYCYGNEFQCHDGSCIPQNWQCDKIKDCQGGEDED-EQCL--VCEPDEFRCRSN-EKCLVEKYRC 490
            |.|..|||||.||.||...|.||..::|..|.||. |.|:  .|...||.|... .:|:.:.:||
  Rat    25 DSCGKNEFQCRDGKCIVSKWVCDGSRECPDGSDESPETCMSVTCRSGEFSCGGRVSRCIPDSWRC 89

  Fly   491 DQNIDCMDGSDEQDCDEYGSGDLAPFDESELNAFPRVFTYASFLSPNETNDKVYTYITATTDEDA 555
            |...||.:||||.||                             ||.          |.:.||
  Rat    90 DGRTDCENGSDELDC-----------------------------SPK----------TCSLDE-- 113

  Fly   556 GTETKFQIHQVAAPAPPVNSSAEEGAGGPKGFVNFR--DSKEIMMTSDSETKFKYSQRANRTSVK 618
                                              ||  |.|.|......:..:.....::.....
  Rat   114 ----------------------------------FRCQDGKCISRQFVCDQDWDCLDGSDEAHCA 144

  Fly   619 FSVSAPTTPAARTSSAIPSS-ALVQQRE--------------RTTSTTTTSTTTSTTTSSITSTP 668
            .:...|......:||.|||. |....|:              |.|:....|:..|:......|:.
  Rat   145 ATTCGPAHFRCNSSSCIPSLWACDGDRDCDDGSDEWPQNCGGRDTAAEVVSSPCSSLEFHCGSSE 209

  Fly   669 SITSTTLIPINAATSEPNPYEVVTSLGGCPPQELRCVSGKCITVSQLCDKQIDCPDAADELMCV 732
            .|..:.:.. .||..:....|...::..|.|.|.:|..|.||..|:.||::.||.|.:|||.|:
  Rat   210 CIHRSWVCD-GAADCKDKSDEENCAVTTCRPDEFQCADGSCIHGSRQCDREHDCKDMSDELGCI 272

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6739	NP_609130.1	CRD_FZ	314..427	CDD:143549
		LDLa	432..464	CDD:238060	16/31 (52%)
		LDLa	470..505	CDD:238060	14/35 (40%)
		LDLa	697..731	CDD:238060	16/33 (48%)
Ldlr	NP_786938.2	Ldl_recept_a	25..58	CDD:395011	16/32 (50%)
		Ldl_recept_a	66..104	CDD:395011	14/37 (38%)
		Ldl_recept_a	107..143	CDD:395011	8/81 (10%)
		Ldl_recept_a	196..232	CDD:395011	6/36 (17%)
		Ldl_recept_a	235..271	CDD:395011	16/35 (46%)
		Ldl_recept_a	279..309	CDD:395011
		FXa_inhibition	319..353	CDD:464251
		EGF_CA	355..389	CDD:214542
		LDL-receptor class B 1	398..439
		NHL	<435..628	CDD:302697
		NHL repeat	435..469	CDD:271320
		LDL-receptor class B 2	440..485
		NHL repeat	476..514	CDD:271320
		LDL-receptor class B 3	486..528
		LDL-receptor class B 4	529..572
		Ldl_recept_b	529..569	CDD:459654
		NHL repeat	555..600	CDD:271320
		LDL-receptor class B 5	573..615
		NHL repeat	606..628	CDD:271320
		LDL-receptor class B 6	616..658
		Ldl_recept_b	616..656	CDD:459654
		FXa_inhibition	674..711	CDD:464251
		Clustered O-linked oligosaccharides	717..788
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	718..797
		Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000250|UniProtKB:P01130	830..879
		NPXY motif. /evidence=ECO:0000250|UniProtKB:P01130	842..847