DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6739 and LRP10

DIOPT Version :9

Sequence 1:	NP_609130.1	Gene:	CG6739 / 34037	FlyBaseID:	FBgn0031926	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	XP_005267567.1	Gene:	LRP10 / 26020	HGNCID:	14553	Length:	721	Species:	Homo sapiens

Alignment Length:	406	Identity:	96/406 - (23%)
Similarity:	131/406 - (32%)	Gaps:	99/406 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   404 LGELFDCNLYPDAHE---SHKCEDPTRRRDY--CYGNEFQCHDG------SCIPQNWQCDKIKDC 457
            |||    ..|.:|..   |..|.|.|...|.  |....|.|...      :|.....:|:....|
Human   335 LGE----RCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATACYLPADRCNYQTFC 395

  Fly   458 QGGEDEDEQCLVCEPDEFRCRSNEKCLVEKYRCDQNIDCMDGSDEQDCDEYGSGDLAPFDESELN 522
            ..|.|| .:|..|:|..|||| :|||:.|.:.||...||.|||||.||.               .
Human   396 ADGADE-RRCRHCQPGNFRCR-DEKCVYETWVCDGQPDCADGSDEWDCS---------------Y 443

  Fly   523 AFPRVFTYASFLS----------PNETNDKVYTYITATTDEDAG-TETKFQIHQVAAP------- 569
            ..||....|:.:.          ......|:|...|......|. :..:.:|.|..||
Human   444 VLPRKVITAAVIGSLVCGLLLVIALGCTCKLYAIRTQEYSIFAPLSRMEAEIVQQQAPPSYGQLI 508

  Fly   570 ----APPVNSSAEEGAGGPKGFVNFRDSKEIM---MTSDSETKFKYSQRAN------RTSVKFSV 621
                .|||.....|.........|.|...:|:   ||.......:..||..      |...::.:
Human   509 AQGAIPPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPGGGPGARRRQRGRLMRRLVRRLRRWGL 573

  Fly   622 SAPTTPAARTSSA----IPSSALVQQRERTTSTTTTSTTTSTTTSSITSTPSITSTTLIPINAAT 682
            ...|...||.|.|    .||:|.::..:..|.....................|.:    |:.:|:
Human   574 LPRTNTPARASEARSQVTPSAAPLEALDGGTGPAREGGAVGGQDGEQAPPLPIKA----PLPSAS 634

  Fly   683 SEPNPYEVVTSLGGCP--PQELRCVSGKCITVSQLCDKQIDCPDAADELMCVYRERPSRRRLTST 745
            :.|.|..|..:.|..|  |.|...:||   .|..|                       |.||..:
Human   635 TSPAPTTVPEAPGPLPSLPLEPSLLSG---VVQAL-----------------------RGRLLPS 673

  Fly   746 TAPPTTSSAPPETSTA 761
            ..||..:.:||...||
Human   674 LGPPGPTRSPPGPHTA 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6739	NP_609130.1	CRD_FZ	314..427	CDD:143549	8/25 (32%)
		LDLa	432..464	CDD:238060	8/37 (22%)
		LDLa	470..505	CDD:238060	19/34 (56%)
		LDLa	697..731	CDD:238060	7/35 (20%)
LRP10	XP_005267567.1	CUB	34..134	CDD:238001
		LDLa	148..182	CDD:238060
		CUB	200..310	CDD:238001
		LDLa	<338..361	CDD:238060	6/22 (27%)
		LDLa	407..441	CDD:238060	19/34 (56%)
		PRK04654	<581..683	CDD:135173	27/131 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810