DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6739 and Lrp4

DIOPT Version :9

Sequence 1:	NP_609130.1	Gene:	CG6739 / 34037	FlyBaseID:	FBgn0031926	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_766256.3	Gene:	Lrp4 / 228357	MGIID:	2442252	Length:	1905	Species:	Mus musculus

Alignment Length:	421	Identity:	85/421 - (20%)
Similarity:	132/421 - (31%)	Gaps:	167/421 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   350 SLIRANCSVRAAEFICGALEPECRPLHIGQLP--PCRRIC--------KAILEACSIPIY----- 399
            :|:.|:....:.|..||.....|....:|:..  |.:..|        .:..:.|::|..
Mouse    12 ALLCAHGIASSLECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCTLPTCSPLDF 76

  Fly   400 ---NSDVLGELFDCNLYPDAHESHKCEDPTRRRD----YCYGNEFQCHDGSCIPQNWQCDKIKDC 457
               |...:...:.|:      ..:.|||.:..:|    .|..:||.|.:|.||...|.||...||
Mouse    77 HCDNGKCIRRSWVCD------GDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDC 135

  Fly   458 QGGEDEDEQCLV--CEPDEFRCRSNEKCLVEKYRCDQNIDCMDGSDEQDCDEYGSGDLAPFDESE 520
              |::.||||.:  |...|||| |:..|:.|.:.||.:.||.|||||:.|..
Mouse   136 --GDNSDEQCDMRKCSDKEFRC-SDGSCIAEHWYCDGDTDCKDGSDEESCPS------------- 184

  Fly   521 LNAFPRVFTYASFLSPNETNDKVYTYITATTDEDAGTETKFQIHQVAAPAPPVNSSAEEGAGGPK 585
                                                          |.|:||.|....:.|.|
Mouse   185 ----------------------------------------------AVPSPPCNLEEFQCAYG-- 201

  Fly   586 GFVNFRDSKEIMMTSDSETKFKYSQRANRTSVKFSVSAPTTPAARTSSAIPSSALV--------- 641
                 |...:|......:....:|..::.:|.:         ..|:...:..|.|.
Mouse   202 -----RCILDIYHCDGDDDCGDWSDESDCSSHQ---------PCRSGEFMCDSGLCINSGWRCDG 252

  Fly   642 ------QQRERTTSTTTTSTTTSTTTSSITSTPSITSTTLIPINAATSEPNPYEVVTSLGGCPPQ 700
                  |..||..:|:.                                            |..:
Mouse   253 DADCDDQSDERNCTTSM--------------------------------------------CTAE 273

  Fly   701 ELRCVSGKCITVSQLCDKQIDCPDAADELMC 731
            :.||.||:|:.:|..||.:.||.|.:||..|
Mouse   274 QFRCRSGRCVRLSWRCDGEDDCADNSDEENC 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6739	NP_609130.1	CRD_FZ	314..427	CDD:143549	16/94 (17%)
		LDLa	432..464	CDD:238060	13/31 (42%)
		LDLa	470..505	CDD:238060	17/34 (50%)
		LDLa	697..731	CDD:238060	14/33 (42%)
Lrp4	NP_766256.3	LDLa	27..66	CDD:238060	6/38 (16%)
		Ldl_recept_a	70..105	CDD:278486	5/40 (13%)
		LDLa	110..142	CDD:238060	14/33 (42%)
		LDLa	148..182	CDD:238060	17/34 (50%)
		LDLa	231..265	CDD:238060	6/33 (18%)
		LDLa	270..304	CDD:238060	14/33 (42%)
		LDLa	311..343	CDD:197566
		FXa_inhibition	358..393	CDD:291342
		EGF_CA	395..434	CDD:214542
		NHL	<471..622	CDD:302697
		NHL repeat	471..507	CDD:271320
		LDL-receptor class B 1	480..522
		LY	505..545	CDD:214531
		NHL repeat	510..550	CDD:271320
		LDL-receptor class B 2	523..565
		NHL repeat	555..589	CDD:271320
		LDL-receptor class B 3	566..609
		LY	590..632	CDD:214531
		NHL repeat	598..622	CDD:271320
		LDL-receptor class B 4	610..652
		LY	633..673	CDD:214531
		LDL-receptor class B 5	653..693
		FXa_inhibition	702..>729	CDD:291342
		LY	766..806	CDD:214531
		LDL-receptor class B 6	785..827
		LY	808..850	CDD:214531
		LDL-receptor class B 7	828..870
		LDL-receptor class B 8	871..914
		Ldl_recept_b	871..911	CDD:278487
		LY	895..937	CDD:214531
		LDL-receptor class B 9	915..956
		LY	938..979	CDD:214531
		LDL-receptor class B 10	957..998
		FXa_inhibition	1006..1043	CDD:291342
		NHL	<1085..1277	CDD:302697
		NHL repeat	1085..1123	CDD:271320
		LDL-receptor class B 11	1093..1135
		NHL repeat	1128..1161	CDD:271320
		LDL-receptor class B 12	1136..1178
		NHL repeat	1166..1203	CDD:271320
		LDL-receptor class B 13	1179..1222
		NHL repeat	1212..1244	CDD:271320
		LDL-receptor class B 14	1223..1263
		NHL repeat	1253..1277	CDD:271320
		LDL-receptor class B 15	1264..1306
		FXa_inhibition	1313..1348	CDD:291342
		LY	1379..1418	CDD:214531
		LDL-receptor class B 16	1397..1439
		LY	1420..1460	CDD:214531
		LDL-receptor class B 17	1440..1482
		LDL-receptor class B 18	1483..1526
		Ldl_recept_b	1483..1523	CDD:278487
		LY	1507..1547	CDD:214531
		LDL-receptor class B 19	1527..1568
		LY	1549..1589	CDD:214531
		LDL-receptor class B 20	1569..1610
		FXa_inhibition	1617..1648	CDD:291342
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1661..1696
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1852..1905
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900