DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6739 and Sorl1

DIOPT Version :10

Sequence 1:NP_609130.1 Gene:CG6739 / 34037 FlyBaseID:FBgn0031926 Length:787 Species:Drosophila melanogaster
Sequence 2:NP_035566.2 Gene:Sorl1 / 20660 MGIID:1202296 Length:2215 Species:Mus musculus


Alignment Length:611 Identity:131/611 - (21%)
Similarity:179/611 - (29%) Gaps:250/611 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   298 PTEAMALTTPSTTNS-------GCQSTMLP----MCQGVLDYDLTFN----REGAAPRDAVSMAA 347
            |.....|..|...||       |..|::||    ||.....|....|    .|....|:....: 
Mouse  1023 PQPCSLLCLPKANNSKSCRCPEGVASSVLPSGDLMCDCPQGYQRKNNTCVKEENTCLRNQYRCS- 1086

  Fly   348 YDSLIRANC--SVRAAEF--ICGALEPE---------------------CRPLHIGQLPPCRRIC 387
                 ..||  |:...:|  .||.:..|                     |.||..          
Mouse  1087 -----NGNCINSIWWCDFDNDCGDMSDERNCPTTVCDADTQFRCQESGTCIPLSY---------- 1136

  Fly   388 KAILE----------ACSIPIYNSDVLGELFDCNLYPDAHESHKCEDPTRRRDY----------- 431
            |..||          .|.:....||.    |:|:.......|..|:.....||:           
Mouse  1137 KCDLEDDCGDNSDESHCEMHQCRSDE----FNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYH 1197

  Fly   432 -CYGNEFQCHDGSCIPQNWQCDKIKDCQGGEDEDE---------------QCLV----------- 469
             |..:.||||:|.||||.|.||...|||.|.|||.               .|:.           
Mouse  1198 TCEASNFQCHNGHCIPQRWACDGDADCQDGSDEDPVSCEKKCNGFHCPNGTCIPSSKHCDGLRDC 1262

  Fly   470 --------CEP-----DEFRCRSNEKCLVEKYRCDQNIDCMDGSDE--------------QDCDE 507
                    |||     .:|.|::.::||.....||..:.|.|||||              ::|||
Mouse  1263 PDGSDEQHCEPFCTRFMDFVCKNRQQCLFHSMVCDGIVQCRDGSDEDAAFAGCSQDPEFHKECDE 1327

  Fly   508 YG--------------------SGDLAPFDESEL---NAFPRVFTYASF------LSPNETN-DK 542
            :|                    .||.:  ||:..   ...|....|..|      ..||... |:
Mouse  1328 FGFQCQNGVCISLIWKCDGMDDCGDYS--DEANCENPTEAPNCSRYFQFHCENGHCIPNRWKCDR 1390

  Fly   543 VYTYITATTDEDAGTETKFQIHQVAAPAP------PVNSSAEEGAGGPKGFV--NFRDSKEIMMT 599
            .......:.::|.|..     |.:.:|.|      |.......||.....:|  .:||..:   .
Mouse  1391 ENDCGDWSDEKDCGDS-----HVLPSPTPGPSTCLPNYFHCSSGACVMGTWVCDGYRDCAD---G 1447

  Fly   600 SDSETKFKYSQRANRTSVKFSVSAPTT---------PAARTSSAIPS------SALVQQRERTTS 649
            ||.|.   ....||.|    :.|.||.         ...:....||:      ....|..:...:
Mouse  1448 SDEEA---CPSLANST----AASTPTQFGQCDRFEFECHQPKKCIPNWKRCDGHQDCQDGQDEAN 1505

  Fly   650 TTTTSTTTSTTTSSITSTPSITSTTLIPINAATSEPNPYEVVTSLGGCPPQELRCVSGK-CITVS 713
            ..|.||.|                                       |..:|.:|..|: ||.:|
Mouse  1506 CPTHSTLT---------------------------------------CTSREFKCEDGEACIVLS 1531

  Fly   714 QLCDKQIDCPDAADELMC-----VYR 734
            :.||..:||.|.:||..|     ||:
Mouse  1532 ERCDGFLDCSDESDEKACSDELTVYK 1557

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6739NP_609130.1 CRD_FZ 314..427 CDD:143549 29/155 (19%)
LDLa 432..464 CDD:238060 18/31 (58%)
LDLa 470..505 CDD:238060 15/53 (28%)
LDLa 697..731 CDD:238060 14/34 (41%)
Sorl1NP_035566.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 59..84
VPS10 124..753 CDD:214740
BNR 1 136..147
BNR 2 232..243
BNR 3 441..452
BNR 4 521..532
BNR 5 562..573
LY 780..821 CDD:214531
LDL-receptor class B 1 800..843
LY 824..866 CDD:214531
LDL-receptor class B 2 844..887
LY 868..910 CDD:214531
LDL-receptor class B 3 888..932
Ldl_recept_b 890..929 CDD:459654
LY 913..953 CDD:214531
LDL-receptor class B 4 933..972
LY 953..987 CDD:214531
LDL-receptor class B 5 973..1013
LDLa 1078..1112 CDD:238060 8/39 (21%)
LDLa 1117..1153 CDD:238060 6/45 (13%)
Ldl_recept_a 1157..1192 CDD:395011 8/38 (21%)
Ldl_recept_a 1198..1230 CDD:395011 17/31 (55%)
LDLa 1240..1271 CDD:238060 1/30 (3%)
LDLa 1281..1308 CDD:197566 10/26 (38%)
LDLa 1325..1359 CDD:238060 8/35 (23%)
LDLa 1373..1403 CDD:238060 4/29 (14%)
LDLa 1419..1453 CDD:238060 9/39 (23%)
LDLa 1471..1506 CDD:238060 3/34 (9%)
LDLa 1514..1549 CDD:238060 14/34 (41%)
FN3 1557..1630 CDD:238020 0/1 (0%)
FN3 1651..1742 CDD:238020
FN3 1690..>2100 CDD:442628
Potential nuclear localization signal for the C-terminal fragment generated by PSEN1. /evidence=ECO:0000250|UniProtKB:Q92673 2162..2165
Endocytosis signal. /evidence=ECO:0000255 2173..2178
Required for efficient Golgi apparatus -endosome sorting. /evidence=ECO:0000250|UniProtKB:Q92673 2191..2215
Required for interaction with GGA1 and GGA2. /evidence=ECO:0000250|UniProtKB:Q92673 2202..2215
DXXLL motif involved in the interaction with GGA1. /evidence=ECO:0000250|UniProtKB:Q92673 2209..2213
Blue background indicates that the domain is not in the aligned region.

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