DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6739 and Sorl1

DIOPT Version :9

Sequence 1:	NP_609130.1	Gene:	CG6739 / 34037	FlyBaseID:	FBgn0031926	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_035566.2	Gene:	Sorl1 / 20660	MGIID:	1202296	Length:	2215	Species:	Mus musculus

Alignment Length:	611	Identity:	131/611 - (21%)
Similarity:	179/611 - (29%)	Gaps:	250/611 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 PTEAMALTTPSTTNS-------GCQSTMLP----MCQGVLDYDLTFN----REGAAPRDAVSMAA 347
            |.....|..|...||       |..|::||    ||.....|....|    .|....|:....:
Mouse  1023 PQPCSLLCLPKANNSKSCRCPEGVASSVLPSGDLMCDCPQGYQRKNNTCVKEENTCLRNQYRCS- 1086

  Fly   348 YDSLIRANC--SVRAAEF--ICGALEPE---------------------CRPLHIGQLPPCRRIC 387
                 ..||  |:...:|  .||.:..|                     |.||..
Mouse  1087 -----NGNCINSIWWCDFDNDCGDMSDERNCPTTVCDADTQFRCQESGTCIPLSY---------- 1136

  Fly   388 KAILE----------ACSIPIYNSDVLGELFDCNLYPDAHESHKCEDPTRRRDY----------- 431
            |..||          .|.:....||.    |:|:.......|..|:.....||:
Mouse  1137 KCDLEDDCGDNSDESHCEMHQCRSDE----FNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYH 1197

  Fly   432 -CYGNEFQCHDGSCIPQNWQCDKIKDCQGGEDEDE---------------QCLV----------- 469
             |..:.||||:|.||||.|.||...|||.|.|||.               .|:.
Mouse  1198 TCEASNFQCHNGHCIPQRWACDGDADCQDGSDEDPVSCEKKCNGFHCPNGTCIPSSKHCDGLRDC 1262

  Fly   470 --------CEP-----DEFRCRSNEKCLVEKYRCDQNIDCMDGSDE--------------QDCDE 507
                    |||     .:|.|::.::||.....||..:.|.|||||              ::|||
Mouse  1263 PDGSDEQHCEPFCTRFMDFVCKNRQQCLFHSMVCDGIVQCRDGSDEDAAFAGCSQDPEFHKECDE 1327

  Fly   508 YG--------------------SGDLAPFDESEL---NAFPRVFTYASF------LSPNETN-DK 542
            :|                    .||.:  ||:..   ...|....|..|      ..||... |:
Mouse  1328 FGFQCQNGVCISLIWKCDGMDDCGDYS--DEANCENPTEAPNCSRYFQFHCENGHCIPNRWKCDR 1390

  Fly   543 VYTYITATTDEDAGTETKFQIHQVAAPAP------PVNSSAEEGAGGPKGFV--NFRDSKEIMMT 599
            .......:.::|.|..     |.:.:|.|      |.......||.....:|  .:||..:   .
Mouse  1391 ENDCGDWSDEKDCGDS-----HVLPSPTPGPSTCLPNYFHCSSGACVMGTWVCDGYRDCAD---G 1447

  Fly   600 SDSETKFKYSQRANRTSVKFSVSAPTT---------PAARTSSAIPS------SALVQQRERTTS 649
            ||.|.   ....||.|    :.|.||.         ...:....||:      ....|..:...:
Mouse  1448 SDEEA---CPSLANST----AASTPTQFGQCDRFEFECHQPKKCIPNWKRCDGHQDCQDGQDEAN 1505

  Fly   650 TTTTSTTTSTTTSSITSTPSITSTTLIPINAATSEPNPYEVVTSLGGCPPQELRCVSGK-CITVS 713
            ..|.||.|                                       |..:|.:|..|: ||.:|
Mouse  1506 CPTHSTLT---------------------------------------CTSREFKCEDGEACIVLS 1531

  Fly   714 QLCDKQIDCPDAADELMC-----VYR 734
            :.||..:||.|.:||..|     ||:
Mouse  1532 ERCDGFLDCSDESDEKACSDELTVYK 1557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6739	NP_609130.1	CRD_FZ	314..427	CDD:143549	29/155 (19%)
		LDLa	432..464	CDD:238060	18/31 (58%)
		LDLa	470..505	CDD:238060	15/53 (28%)
		LDLa	697..731	CDD:238060	14/34 (41%)
Sorl1	NP_035566.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..84
		VPS10	124..753	CDD:214740
		BNR 1	136..147
		BNR 2	232..243
		BNR 3	441..452
		BNR 4	521..532
		BNR 5	562..573
		Sortilin_C	588..753	CDD:292523
		LY	780..821	CDD:214531
		LDL-receptor class B 1	800..843
		LY	824..866	CDD:214531
		LDL-receptor class B 2	844..887
		LY	868..910	CDD:214531
		LDL-receptor class B 3	888..932
		Ldl_recept_b	890..929	CDD:278487
		LY	913..953	CDD:214531
		LDL-receptor class B 4	933..972
		LDL-receptor class B 5	973..1013
		LDLa	1078..1112	CDD:238060	8/39 (21%)
		LDLa	1117..1153	CDD:238060	6/45 (13%)
		Ldl_recept_a	1157..1192	CDD:278486	8/38 (21%)
		Ldl_recept_a	1198..1230	CDD:278486	17/31 (55%)
		LDLa	1240..1271	CDD:238060	1/30 (3%)
		LDLa	1281..1308	CDD:197566	10/26 (38%)
		LDLa	1325..1359	CDD:238060	8/35 (23%)
		LDLa	1373..1403	CDD:238060	4/29 (14%)
		LDLa	1419..1453	CDD:238060	9/39 (23%)
		LDLa	1471..1506	CDD:238060	3/34 (9%)
		LDLa	1514..1549	CDD:238060	14/34 (41%)
		FN3	1557..1630	CDD:238020	0/1 (0%)
		FN3	1651..1742	CDD:238020
		FN3	1752..1831	CDD:238020
		FN3	1935..2022	CDD:238020
		FN3	2026..2113	CDD:238020
		Potential nuclear localization signal for the C-terminal fragment generated by PSEN1. /evidence=ECO:0000250\|UniProtKB:Q92673	2162..2165
		Endocytosis signal. /evidence=ECO:0000255	2173..2178
		Required for efficient Golgi apparatus -endosome sorting. /evidence=ECO:0000250\|UniProtKB:Q92673	2191..2215
		Required for interaction with GGA1 and GGA2. /evidence=ECO:0000250\|UniProtKB:Q92673	2202..2215
		DXXLL motif involved in the interaction with GGA1. /evidence=ECO:0000250\|UniProtKB:Q92673	2209..2213
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900