DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6739 and EGF

DIOPT Version :10

Sequence 1:NP_609130.1 Gene:CG6739 / 34037 FlyBaseID:FBgn0031926 Length:787 Species:Drosophila melanogaster
Sequence 2:NP_001954.2 Gene:EGF / 1950 HGNCID:3229 Length:1207 Species:Homo sapiens


Alignment Length:479 Identity:98/479 - (20%)
Similarity:144/479 - (30%) Gaps:134/479 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   382 PCRRICKAILEACSIPIYNSDVLGELFDC-NLYPDAHESHKCEDPTRRRDYCYGNEFQCHDGSCI 445
            |.:::||.....||..:...|:...|..| ..|..:.:...|||......:.:|....|.:   .
Human   313 PEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKN---T 374

  Fly   446 PQNWQCDKIKDCQGGEDEDEQCLVCEPDEFRCRSNEKCLVEKYRCDQNI-DCMDGSDEQDCDEYG 509
            |.::.|    .|..|       .|..||..||..    ||.   |.:|: :|     ..||....
Human   375 PGSYYC----TCPVG-------FVLLPDGKRCHQ----LVS---CPRNVSEC-----SHDCVLTS 416

  Fly   510 SGDLAPFDESELNAFPRVFTYASFLSPNETNDKVYTYITATTDEDAGTETKFQIHQVAAPAPPVN 574
            .|.|....|.               |..|.:.|  |....::.::.|..      |:..|..||:
Human   417 EGPLCFCPEG---------------SVLERDGK--TCSGCSSPDNGGCS------QLCVPLSPVS 458

  Fly   575 -------------SSAEEGAGGPKGFVNFRDSKEIM-MTSD------------------------ 601
                         ......|.||:.|:.|.:|::|. |..|                        
Human   459 WECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVE 523

  Fly   602 -----SETKFKYSQRANRTS------VKFSVSAPTTPAA-----------RTSSAIPSSALVQQR 644
                 :.|..|:.:|||...      ::..|..|...|.           |..|.|..|.|..:|
Human   524 NKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKR 588

  Fly   645 ERTTSTTTTSTTTSTTTSSITSTPSITSTTLIPINAATSEPNPYEVVTSLGG-----CPPQELRC 704
            .:..:....|.........:......|.|.:          ||....:||.|     ....:|..
Human   589 SKIITKENISQPRGIAVHPMAKRLFWTDTGI----------NPRIESSSLQGLGRLVIASSDLIW 643

  Fly   705 VSGKCITVSQLCDKQIDCPDAADELMCVYRERPSRRRLTSTTAPPTTSSAPPETSTATTTTGPLS 769
            .||  ||:..|.||...|......:.....:...|||||........:.|..|.....:.....|
Human   644 PSG--ITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPS 706

  Fly   770 STRRSLRTTPNRSR------KPKS 787
            ..|.:.||..:|.|      ||.|
Human   707 VMRVNKRTGKDRVRLQGSMLKPSS 730

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6739NP_609130.1 CRD_FZ 314..427 CDD:143549 12/45 (27%)
LDLa 432..464 CDD:238060 6/31 (19%)
LDLa 470..505 CDD:238060 9/35 (26%)
LDLa 697..731 CDD:238060 9/33 (27%)
EGFNP_001954.2 TolB 47..190 CDD:440585
LDL-receptor class B 1 86..127
LDL-receptor class B 2 128..169
LY 152..189 CDD:214531
LDL-receptor class B 3 170..211
LDL-receptor class B 4 212..258
EGF_CA 356..395 CDD:214542 10/52 (19%)
FXa_inhibition 408..436 CDD:464251 9/49 (18%)
FXa_inhibition 439..476 CDD:464251 5/42 (12%)
LDL-receptor class B 5 483..523 6/39 (15%)
LY 505..546 CDD:214531 5/40 (13%)
LDL-receptor class B 6 524..566 8/41 (20%)
LY 547..587 CDD:214531 8/39 (21%)
LDL-receptor class B 7 567..609 7/41 (17%)
LY 590..633 CDD:214531 8/52 (15%)
LDL-receptor class B 8 610..653 12/54 (22%)
LY 635..676 CDD:214531 9/42 (21%)
LDL-receptor class B 9 654..696 10/41 (24%)
LY 677..718 CDD:214531 10/40 (25%)
FXa_inhibition 745..780 CDD:464251
O-glycosylated at one site 801..807
EGF 835..864 CDD:394967
EGF_CA 870..910 CDD:214542
EGF_CA 912..940 CDD:429571
PHA03099 <976..>1014 CDD:165381
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1067..1093
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1108..1131
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1177..1207
Blue background indicates that the domain is not in the aligned region.

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