DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6739 and lrp-1

DIOPT Version :9

Sequence 1:	NP_609130.1	Gene:	CG6739 / 34037	FlyBaseID:	FBgn0031926	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001379135.1	Gene:	lrp-1 / 172520	WormBaseID:	WBGene00003071	Length:	4753	Species:	Caenorhabditis elegans

Alignment Length:	624	Identity:	138/624 - (22%)
Similarity:	185/624 - (29%)	Gaps:	238/624 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 DESTELPE----IAFGDDGDPEAGGEDGDGDYDDTLLPADSIRFTSGHQNSFG-----------V 251
            |.|.||.:    :|..|.|.|.|...|   .:.|.|...|:      |.|..|           :
Worm  3464 DGSPELQDPIFKLAEHDLGWPNAIAID---YFSDRLFWGDA------HLNEIGFMDFDGNGRRHI 3519

  Fly   252 PIEQDKRMLQL-------------LKELLHKPQATPAGNEPTLTRVSPTLPPPLSASGRPTEAMA 303
            |.::...:..:             |:|:|...:.|  |...|:.:.:..||..|... .|....|
Worm  3520 PAQRTSHVSSMVVFDDYLYWADWNLREVLRCDKWT--GKNETILKKTVQLPNDLRIV-HPMRQPA 3581

  Fly   304 LTTP-STTNSGCQSTMLPMCQGVLDYDLTFNREGAAPRDAVSMAAYDSLIRANCSVRAAEFICGA 367
            ...| ...|.||....|....|        |....:..|...:.:.......||:.|  :|.||.
Worm  3582 YPNPCGDNNGGCSHLCLIGAGG--------NGYTCSCPDQFVLLSDQKTCEPNCTER--QFACGG 3636

  Fly   368 LEPECRP--LHIGQLPPCR-------------RICKAILEACSIPIYNSDVLGELFDCNLYPDAH 417
            .:.:|.|  .:....|.||             |||         |:      || |.|.
Worm  3637 DDAKCIPKLWYCDGEPDCRDGSDEPGESICGQRIC---------PV------GE-FQCT------ 3679

  Fly   418 ESHKCEDPTRRRDYCYGNE-------------------FQC-HDGSCIPQNWQCDKIKDCQGGED 462
             :|.|   ||....|.||:                   |:| ..|.|||:.:.||...||....|
Worm  3680 -NHNC---TRPFQICDGNDDCGDSSDEQNCDKACDPWMFKCAATGRCIPRRFTCDGDDDCGDRSD 3740

  Fly   463 E-DEQCLV----CEPDEFRCRSNEKCLVEKYRCDQNIDCMDGSDEQDCDEYGSGDLAPFDESELN 522
            | |..|:.    |..:|||| :|.||:.:.:|||.:.||.|||||
Worm  3741 EADTLCMSAERNCTAEEFRC-NNNKCIAKAWRCDNDDDCGDGSDE-------------------- 3784

  Fly   523 AFPRVFTYASFLSPNETNDKVYTYITATTDEDAGTETKFQIHQVAAPAPPVNSSAEEGAGGPKGF 587
                                        |.|.|..|.|                        ||:
Worm  3785 ----------------------------TPECAQIECK------------------------KGW 3797

  Fly   588 VNFRDSKEIMMTSDSETKFKYSQRANRTSVKFSVSAPTTPAARTSSAIPSSALVQQRERTTSTTT 652
                            |:...|.|                      .||:.|....::.....:.
Worm  3798 ----------------TRCSSSYR----------------------CIPNWAFCNGQDDCRDNSD 3824

  Fly   653 TSTTTSTTTSSITSTPSITSTTLIPINAATSEPNPY-----EVVTSLGG----CPPQELRCVSGK 708
            .......|...:......||...||........|..     |:..|.||    |...|.||..||
Worm  3825 EDKQRCPTCDDVGEFRCATSGKCIPRRWMCDTENDCGDNSDELDASCGGTTRPCSESEFRCNDGK 3889

  Fly   709 CITVSQLCDKQIDCPDAADELMCVYRE-RPSRRRLTSTT 746
            ||..|::||..|.|.|..||..|..|. .|..|:....|
Worm  3890 CIPGSKVCDGTIQCSDGLDESQCTLRRCLPGHRQCDDGT 3928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6739	NP_609130.1	CRD_FZ	314..427	CDD:143549	26/127 (20%)
		LDLa	432..464	CDD:238060	15/52 (29%)
		LDLa	470..505	CDD:238060	18/34 (53%)
		LDLa	697..731	CDD:238060	16/33 (48%)
lrp-1	NP_001379135.1	LDLa	53..87	CDD:238060
		LDLa	92..131	CDD:238060
		LDLa	140..173	CDD:238060
		LDLa	182..216	CDD:238060
		LDLa	223..257	CDD:238060
		LDLa	262..297	CDD:238060
		LY	463..505	CDD:214531
		LY	507..546	CDD:214531
		LY	547..589	CDD:214531
		LY	883..925	CDD:214531
		exchanger_TraA	<1054..1451	CDD:411343
		LDLa	1057..1087	CDD:197566
		LDLa	1146..1177	CDD:197566
		LDLa	1187..1219	CDD:238060
		LDLa	1228..1263	CDD:238060
		LDLa	1270..1302	CDD:238060
		LDLa	1313..1344	CDD:238060
		FXa_inhibition	1447..1475	CDD:405372
		LY	1511..1545	CDD:214531
		LY	1548..1585	CDD:214531
		LY	1590..1634	CDD:214531
		LY	1635..1677	CDD:214531
		Ldl_recept_b	1943..1986	CDD:423042
		LY	1971..2012	CDD:214531
		LY	2015..2052	CDD:214531
		LY	2193..2239	CDD:214531
		LY	2240..2283	CDD:214531
		LY	2284..2325	CDD:214531
		LY	2570..2612	CDD:214531
		LY	2613..2655	CDD:214531
		LDLa	2794..2824	CDD:197566
		LDLa	2834..2868	CDD:238060
		LDLa	2874..2907	CDD:197566
		LDLa	2961..2994	CDD:238060
		LDLa	3012..3038	CDD:238060
		LDLa	3048..3088	CDD:197566
		LDLa	3099..3131	CDD:197566
		LDLa	3140..3174	CDD:238060
		LDLa	3186..3218	CDD:197566
		FXa_inhibition	3276..3305	CDD:405372
		LY	3382..3424	CDD:214531
		Ldl_recept_b	3445..3490	CDD:395012	9/25 (36%)
		LY	3476..3516	CDD:214531	12/48 (25%)
		FXa_inhibition	3586..3623	CDD:405372	7/44 (16%)
		LDLa	3627..3660	CDD:197566	10/34 (29%)
		LDLa	3671..3705	CDD:238060	13/59 (22%)
		LDLa	3792..3825	CDD:197566	10/94 (11%)
		LDLa	3837..3868	CDD:238060	6/30 (20%)
		LDLa	3878..3912	CDD:238060	16/33 (48%)
		LDLa	3917..3951	CDD:238060	3/12 (25%)
		LDLa	3958..3990	CDD:197566
		LDLa	4049..4083	CDD:238060
		FXa_inhibition	4097..>4121	CDD:405372
		EGF_CA	4132..4163	CDD:214542
		NHL	4219..>4431	CDD:302697
		NHL repeat	4219..4257	CDD:271320
		NHL repeat	4267..4330	CDD:271320
		NHL repeat	4333..4371	CDD:271320
		NHL repeat	4373..4410	CDD:271320
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810