DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6739 and Lrp6

DIOPT Version :9

Sequence 1:	NP_609130.1	Gene:	CG6739 / 34037	FlyBaseID:	FBgn0031926	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_032540.2	Gene:	Lrp6 / 16974	MGIID:	1298218	Length:	1613	Species:	Mus musculus

Alignment Length:	429	Identity:	97/429 - (22%)
Similarity:	139/429 - (32%)	Gaps:	140/429 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   349 DSLIRANCSVRAA----EFICGALEPECRPLHIGQLPPCRRICKAILEACSIPIYNSDVLGELFD 409
            |...|.:|.:...    |..||. .|.|.|...               .|    :..|:     |
Mouse  1223 DGTTRCSCPMHLVLLQDELSCGE-PPTCSPQQF---------------TC----FTGDI-----D 1262

  Fly   410 CNLYPDAHESHKCEDPTRRRDY--------CYGNEFQCHDGSCIPQNWQCDKIKDCQGGEDEDEQ 466
            |  .|.|   .:|:..|...|:        |..::|||..|.||....:|:...:||...||...
Mouse  1263 C--IPVA---WRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1322

  Fly   467 CLVCEPDEFRCRSNEKCLVEKYRCDQNIDCMDGSDEQDCDEYGSGDLAPFDESELNAFPRV---- 527
            .::|..|:||| :|.:|:.:..:||.::||.|.|||.||  |.:.:.||...:.:.:...|
Mouse  1323 EVLCLIDQFRC-ANGQCVGKHKKCDHSVDCSDRSDELDC--YPTEEPAPQATNTVGSVIGVIVTI 1384

  Fly   528 -------FTYASFLSPNETNDKVYTYITATTDEDAGTETKFQIHQVAA------PAPPVNSSAEE 579
                   |.....|.|....|..    |.|.|        :.:|..|:      |.|...|.:..
Mouse  1385 FVSGTIYFICQRMLCPRMKGDGE----TMTND--------YVVHSPASVPLGYVPHPSSLSGSLP 1437

  Fly   580 GAGGPKGFVNFRDSKEIM-----------------MTSDSETK---------------------- 605
            |....|..::   |..||                 .:|.|.||
Mouse  1438 GMSRGKSMIS---SLSIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATERSHYT 1499

  Fly   606 --FKYSQRANRTSVKFS--------VSAPTTPAARTSSAIPSSALVQQRERTTSTTTTSTTTSTT 660
              |.||..:..|...:|        .:.||||.   |:.:..|.....|..|:..|....|:...
Mouse  1500 MEFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPC---STDVCDSDYAPSRRMTSVATAKGYTSDVN 1561

  Fly   661 TSSITSTPSITSTTLIPINAATSEPNPYEVVTSLGGCPP 699
            ..|....|..|     |.:...|....||      .|||
Mouse  1562 YDSEPVPPPPT-----PRSQYLSAEENYE------SCPP 1589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6739	NP_609130.1	CRD_FZ	314..427	CDD:143549	16/81 (20%)
		LDLa	432..464	CDD:238060	11/31 (35%)
		LDLa	470..505	CDD:238060	15/34 (44%)
		LDLa	697..731	CDD:238060	3/3 (100%)
Lrp6	NP_032540.2	Beta-propeller 1	20..275
		NHL	55..272	CDD:302697
		NHL repeat	55..93	CDD:271320
		LY	89..127	CDD:214531
		NHL repeat	97..132	CDD:271320
		NHL repeat	140..176	CDD:271320
		Ldl_recept_b	150..190	CDD:278487
		LY	175..216	CDD:214531
		NHL repeat	181..217	CDD:271320
		NHL repeat	226..253	CDD:271320
		LDL-receptor class B 5	236..277
		FXa_inhibition	286..323	CDD:291342
		Beta-propeller 2	328..589
		LY	353..393	CDD:214531
		LY	397..437	CDD:214531
		LY	438..481	CDD:214531
		LY	483..524	CDD:214531
		LY	525..558	CDD:214531
		FXa_inhibition	592..627	CDD:291342
		Beta-propeller 3	631..890
		LY	656..694	CDD:214531
		LY	697..739	CDD:214531
		LY	740..783	CDD:214531
		LY	783..825	CDD:214531
		LY	827..866	CDD:214531
		FXa_inhibition	893..929	CDD:291342
		Beta-propeller 4	933..1202
		LY	958..998	CDD:214531
		LY	1050..1093	CDD:214531
		LY	1094..1136	CDD:214531
		FXa_inhibition	1207..1243	CDD:291342	4/19 (21%)
		LDLa	1249..1285	CDD:238060	11/64 (17%)
		LDLa	1288..1322	CDD:238060	12/33 (36%)
		LDLa	1326..1360	CDD:238060	15/34 (44%)
		PPPSP motif A	1487..1493		0/5 (0%)
		PPPSP motif B	1527..1534		4/9 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1556..1613		11/45 (24%)
		PPPSP motif C	1568..1575		3/11 (27%)
		PPPSP motif D	1588..1593		2/2 (100%)
		PPPSP motif E	1603..1610
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900