DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6739 and Lrp5

DIOPT Version :10

Sequence 1:NP_609130.1 Gene:CG6739 / 34037 FlyBaseID:FBgn0031926 Length:787 Species:Drosophila melanogaster
Sequence 2:NP_032539.2 Gene:Lrp5 / 16973 MGIID:1278315 Length:1614 Species:Mus musculus


Alignment Length:411 Identity:94/411 - (22%)
Similarity:144/411 - (35%) Gaps:120/411 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   364 IC---GALEPECR-PLHIGQL--------PPCRRICKAILEACSIPIYNSDVLGELFDCNLYPDA 416
            ||   |...|.|. |:|:..|        ||   .|.....||:..  ..|.:...:.|:.:|: 
Mouse  1226 ICIAKGDGTPRCSCPVHLVLLQNLLTCGEPP---TCSPDQFACTTG--EIDCIPGAWRCDGFPE- 1284

  Fly   417 HESHKCEDPTRRR--DYCYGNEFQCHDGSCIPQNWQCDKIKDCQGGEDEDEQCLVCEPDEFRCRS 479
                 |.|.:...  ..|..::|.|..|.|:....:||...|||...||.....||.|::|||.|
Mouse  1285 -----CADQSDEEGCPVCSASQFPCARGQCVDLRLRCDGEADCQDRSDEANCDAVCLPNQFRCTS 1344

  Fly   480 NEKCLVEKYRCDQNIDCMDGSDEQDCDEYGSGDLAPFDESELNAFPR--VFTYASFLSP------ 536
            .: |::.|.:||...||.|||||..|              |:|..|.  :..::|.:.|      
Mouse  1345 GQ-CVLIKQQCDSFPDCADGSDELMC--------------EINKPPSDDIPAHSSAIGPVIGIIL 1394

  Fly   537 ------------NETNDKVYTYITATTDEDAGTETKFQIHQVAAPAP--PVNSSAEEGAG----- 582
                        .....:.||          |....|. |:....||  |:|..|..|:.     
Mouse  1395 SLFVMGGVYFVCQRVMCQRYT----------GASGPFP-HEYVGGAPHVPLNFIAPGGSQHGPFP 1448

  Fly   583 ---------------GPKGFVNFRDSKEIMMTSDSETKFKYSQRANRTSVKFSVSAPTTPAART- 631
                           |.:|.|...|...:...|.|.     |.....|.....::.|.:||... 
Mouse  1449 GIPCSKSVMSSMSLVGGRGSVPLYDRNHVTGASSSS-----SSSTKATLYPPILNPPPSPATDPS 1508

  Fly   632 --------SSAIPSSALVQQRE--RTTSTTTTSTTTSTTTSSITSTPSITSTTLIPINAATSEPN 686
                    ||.||::|...:..  |..:..||..:|....|..:::...:|...:.:|   |:.:
Mouse  1509 LYNVDVFYSSGIPATARPYRPYVIRGMAPPTTPCSTDVCDSDYSTSRWKSSKYYLDLN---SDSD 1570

  Fly   687 PY--------EVVTSLGGCPP 699
            ||        :.:::...|||
Mouse  1571 PYPPPPTPHSQYLSAEDSCPP 1591

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6739NP_609130.1 CRD_FZ 314..427 CDD:143549 18/74 (24%)
LDLa 432..464 CDD:238060 11/31 (35%)
LDLa 470..505 CDD:238060 17/34 (50%)
LDLa 697..731 CDD:238060 3/3 (100%)
Lrp5NP_032539.2 YncE 4..213 CDD:442618
Beta-propeller 1 31..287
LY 101..141 CDD:214531
Ldl_recept_b 162..202 CDD:459654
LY 186..228 CDD:214531
LY 229..270 CDD:214531
LDL-receptor class B 5 247..289
FXa_inhibition 298..335 CDD:464251
Beta-propeller 2 340..601
LY 365..405 CDD:214531
LY 407..449 CDD:214531
LY 450..493 CDD:214531
LY 494..536 CDD:214531
LY 537..570 CDD:214531
FXa_inhibition 604..639 CDD:464251
Beta-propeller 3 643..902
YncE <653..781 CDD:442618
LY 709..751 CDD:214531
LY 798..837 CDD:214531
LY 837..878 CDD:214531
FXa_inhibition 905..940 CDD:464251
Beta-propeller 4 944..1211
LY 969..1008 CDD:214531
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1002..1025
LY 1059..1102 CDD:214531
LY 1103..1145 CDD:214531
FXa_inhibition 1216..1252 CDD:464251 8/25 (32%)
LDLa 1258..1294 CDD:238060 8/43 (19%)
LDLa 1297..1331 CDD:238060 12/33 (36%)
LDLa 1335..1369 CDD:238060 17/34 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1474..1498 4/28 (14%)
PPPSP motif A 1499..1505 2/5 (40%)
PPPSP motif B 1537..1544 2/6 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1567..1599 6/25 (24%)
PPPSP motif C 1573..1580 0/6 (0%)
PPPSP motif D 1590..1595 2/2 (100%)
PPPSP motif E 1604..1611
Blue background indicates that the domain is not in the aligned region.

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