Protein Alignment CG6739 and Ldlr

DIOPT Version :10

• Sequence 1: NP_609130.1
• Gene: CG6739 / 34037
• FlyBaseID: FBgn0031926
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_034830.2
• Gene: Ldlr / 16835
• MGIID: 96765
• Length: 862
• Species: Mus musculus
• Alignment Length: 323
• Identity: 80/323 - (24%)
• Similarity: 117/323 - (36%)
• Gaps: 95/323 - (29%)

  Fly   430 DYCYGNEFQCHDGSCIPQNWQCDKIKDCQGGEDED-EQCL--VCEPDEFRCRSN-EKCLVEKYRC 490
            |.|..|||||.||.||...|.||...:|..|.||. |.|:  .|:.::|.|... .:|:.:.:||
Mouse    25 DSCSRNEFQCRDGKCIASKWVCDGSPECPDGSDESPETCMSVTCQSNQFSCGGRVSRCIPDSWRC 89

  Fly   491 DQNIDCMDGSDEQDC-------DEYGSGDLAPFDESELNAFPRVFTYASFLSPNETNDKVYTYIT 548
            |..:||.:.||||.|       |::...|                  ...:||....|
Mouse    90 DGQVDCENDSDEQGCPPKTCSQDDFRCQD------------------GKCISPQFVCD------- 129

  Fly   549 ATTDEDA--GTETKFQIHQVAAPAPPVNSSAEEGAGGPKGFVNFRDSKEIMMTS----DSETKFK 607
              .|.|.  |::   :.|..|....|               .:||.:..|.:.|    |.:
Mouse   130 --GDRDCLDGSD---EAHCQATTCGP---------------AHFRCNSSICIPSLWACDGD---- 170

  Fly   608 YSQRANRTSVKFSVSAPTTPAARTSSAIPSSALVQQRERTTSTTTTSTTTSTTTSSITSTPSITS 672
                              ......|...|.:.    :.|.|::...|:..|:......|:..|..
Mouse   171 ------------------VDCVDGSDEWPQNC----QGRDTASKGVSSPCSSLEFHCGSSECIHR 213

  Fly   673 TTLIPINAATSEPNPYE---VVTSLGGCPPQELRCVSGKCITVSQLCDKQIDCPDAADELMCV 732
            :.:....|...:.:..|   |.|    |.|.|.:|..|.||..|:.||::.||.|.:|||.||
Mouse   214 SWVCDGEADCKDKSDEEHCAVAT----CRPDEFQCADGSCIHGSRQCDREHDCKDMSDELGCV 272

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6739	NP_609130.1	CRD_FZ	314..427	CDD:143549
		LDLa	432..464	CDD:238060	16/31 (52%)
		LDLa	470..505	CDD:238060	13/35 (37%)
		LDLa	697..731	CDD:238060	16/33 (48%)
Ldlr	NP_034830.2	Ldl_recept_a	25..58	CDD:395011	16/32 (50%)
		Ldl_recept_a	66..104	CDD:395011	13/37 (35%)
		Ldl_recept_a	107..143	CDD:395011	8/65 (12%)
		Ldl_recept_a	146..184	CDD:395011	8/74 (11%)
		Ldl_recept_a	196..232	CDD:395011	5/35 (14%)
		Ldl_recept_a	236..271	CDD:395011	17/38 (45%)
		Ldl_recept_a	279..309	CDD:395011
		FXa_inhibition	319..>347	CDD:464251
		EGF_CA	355..389	CDD:214542
		LDL-receptor class B 1	398..439
		LY	420..458	CDD:214531
		LDL-receptor class B 2	440..485
		Ldl_recept_b	440..483	CDD:459654
		LDL-receptor class B 3	486..528
		Ldl_recept_b	486..526	CDD:459654
		LDL-receptor class B 4	529..572
		Ldl_recept_b	529..569	CDD:459654
		LY	553..595	CDD:214531
		LDL-receptor class B 5	573..615
		LDL-receptor class B 6	616..658
		Ldl_recept_b	616..656	CDD:459654
		FXa_inhibition	675..712	CDD:464251
		Clustered O-linked oligosaccharides	722..770
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	730..761
		Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000250|UniProtKB:P01130	813..862
		NPXY motif. /evidence=ECO:0000250|UniProtKB:P01130	825..830