DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6739 and Lrp2

DIOPT Version :10

Sequence 1:	NP_609130.1	Gene:	CG6739 / 34037	FlyBaseID:	FBgn0031926	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001074557.1	Gene:	Lrp2 / 14725	MGIID:	95794	Length:	4660	Species:	Mus musculus

Alignment Length:	499	Identity:	107/499 - (21%)
Similarity:	161/499 - (32%)	Gaps:	184/499 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 PTEAMALTTP-STTNSGCQSTMLPMCQGVLDYDLTFNREGAAPRDAVSMAAYD-SLIRANCSVRA 360
            |.....::.| :|.|.||....|....|     ..|..|  .|.|..::...| :|....||  :
Mouse  3461 PYRQPIMSNPCATNNGGCSHLCLIKAGG-----RGFTCE--CPDDFQTVQLRDRTLCMPMCS--S 3516

  Fly   361 AEFICGALEPECRPLH---IGQLPPCRRICKAILEACSIPIYNSDVLGELFDCNLYPDAHESHKC 422
            .:|:||..| :|.|:.   .||            :.||.....||:....| |.|.........|
Mouse  3517 TQFLCGNNE-KCIPIWWKCDGQ------------KDCSDGSDESDLCPHRF-CRLGQFQCRDGNC 3567

  Fly   423 EDP----TRRRD---------------YCYGNEFQCHDGSCIPQNWQCDKIKDCQGGEDED-EQC 467
            ..|    ..|:|               .|..||:||.:..|||:.||||.:.||....||| ..|
Mouse  3568 TSPQALCNARQDCADGSDEDRVLCEHHRCEANEWQCANKRCIPEYWQCDSVDDCLDNSDEDPSHC 3632

  Fly   468 L--VCEPDEFRCRSNEKCLVEKYRCDQNIDCMDGSDEQDCDEYGSGDLAPFDESELNAFPRVFTY 530
            .  .|.|.:|:| :|.:|:.:.::||.:.||.|.|||
Mouse  3633 ASRTCRPGQFKC-NNGRCIPQSWKCDVDNDCGDYSDE---------------------------- 3668

  Fly   531 ASFLSPNETNDKVYTYITATTDEDAGTETKFQIHQVAAPAPPV--------NSSAEEGAGG---- 583
                       .::..:||..:.|..||...:.:....|...|        ::|.|:|...
Mouse  3669 -----------PIHECMTAAYNCDNHTEFSCKTNYRCIPQWAVCNGFDDCRDNSDEQGCESVPCH 3722

  Fly   584 PKGFVNFR-----------------------DSKEIMMTSDSETKFKYSQRANRTSVKFSVSAPT 625
            |.|  :||                       |.:..:....:|::|:.:.:
Mouse  3723 PSG--DFRCGNHHCIPLRWKCDGIDDCGDNSDEESCVPRECTESEFRCADQ-------------- 3771

  Fly   626 TPAARTSSAIPSSALVQQRERTTSTTTTSTTTSTTTSSITSTPSITSTTLIPINAATSEPNPYEV 690
                   ..|||..:..|....                                ...|:....|:
Mouse  3772 -------QCIPSRWVCDQENDC--------------------------------GDNSDERDCEM 3797

  Fly   691 VTSLGGCPPQELRCVSGKCITVSQLCDKQIDCPDAADELMCVYR 734
            .|    |.|:..:|.||.|:..:..||.:.||.||:||..|..|
Mouse  3798 KT----CHPEHFQCTSGHCVPKALACDGRADCLDASDESACPTR 3837

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

Gene	Sequence	Domain	Region	External ID	Identity
CG6739	NP_609130.1	CRD_FZ	314..427	CDD:143549	28/120 (23%)
		LDLa	432..464	CDD:238060	15/31 (48%)
		LDLa	470..505	CDD:238060	14/34 (41%)
		LDLa	697..731	CDD:238060	14/33 (42%)
Lrp2	NP_001074557.1	LDLa	28..62	CDD:238060
		LDLa	67..99	CDD:197566
		LDLa	108..142	CDD:238060
		LDLa	148..179	CDD:238060
		LDLa	183..217	CDD:238060
		LDLa	222..256	CDD:238060
		LDLa	265..299	CDD:238060
		YncE	<427..576	CDD:442618
		LDL-receptor class B 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	435..477
		LDL-receptor class B 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	478..520
		LY	502..547	CDD:214531
		LDL-receptor class B 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	521..567
		LY	550..590	CDD:214531
		LDL-receptor class B 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	568..612
		FXa_inhibition	662..703	CDD:464251
		LDL-receptor class B 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	752..794
		LY	775..817	CDD:214531
		LDL-receptor class B 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	795..836
		LDL-receptor class B 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	837..880
		Ldl_recept_b	837..878	CDD:459654
		LY	863..903	CDD:214531
		LDL-receptor class B 8. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	881..924
		FXa_inhibition	980..1012	CDD:464251
		LDLa	1025..1059	CDD:238060
		Ldl_recept_a	1065..1101	CDD:395011
		LDLa	1110..1144	CDD:238060
		LDLa	1150..1184	CDD:238060
		LDLa	1188..1223	CDD:238060
		LDLa	1231..1263	CDD:197566
		LDLa	1272..1306	CDD:238060
		LDLa	1313..1345	CDD:197566
		FXa_inhibition	1354..1389	CDD:464251
		EGF_CA	1391..1430	CDD:214542
		LDL-receptor class B 9. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1479..1521
		LY	1502..1544	CDD:214531
		LDL-receptor class B 10. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1522..1564
		LY	1546..1590	CDD:214531
		LDL-receptor class B 11. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1567..1610
		LY	1592..1633	CDD:214531
		LDL-receptor class B 12. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1611..1655
		LDL-receptor class B 13. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1656..1696
		FXa_inhibition	1710..1741	CDD:464251
		LDL-receptor class B 14. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1791..1833
		LDL-receptor class B 15. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1834..1883
		LDL-receptor class B 16. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1884..1931
		Ldl_recept_b	1884..1929	CDD:459654
		LY	1912..1954	CDD:214531
		LDL-receptor class B 17. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1932..1973
		LDL-receptor class B 18. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1974..2014
		YncE	2035..2277	CDD:442618
		LDL-receptor class B 19. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2108..2157
		LDL-receptor class B 20. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2158..2202
		LY	2183..2226	CDD:214531
		LDL-receptor class B 21. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2203..2246
		LDL-receptor class B 22. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2247..2290
		LDL-receptor class B 23. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2291..2333
		FXa_inhibition	2347..2383	CDD:464251
		LDL-receptor class B 24. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2432..2478
		LY	2460..2501	CDD:214531
		LDL-receptor class B 25. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2479..2519
		LY	2503..2543	CDD:214531
		LDL-receptor class B 26. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2520..2563
		LDL-receptor class B 27. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2564..2605
		LY	<2595..2626	CDD:214531
LDL-receptor class B 28. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2606..2647
FXa_inhibition	2656..2693	CDD:464251
LDLa	2700..2732	CDD:197566
LDLa	2742..2776	CDD:238060
LDLa	2783..2818	CDD:238060
LDLa	2822..2855	CDD:197566
LDLa	2865..2899	CDD:238060
LDLa	2908..2939	CDD:197566
LDLa	2950..2986	CDD:197566
LDLa	2995..3029	CDD:238060
LDLa	3034..3066	CDD:238060
LDLa	3077..3111	CDD:238060
FXa_inhibition	3124..3152	CDD:464251
vWFA	<3149..3192	CDD:469594
LY	3221..3262	CDD:214531
LDL-receptor class B 29. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3241..3283
LY	3264..3306	CDD:214531
Ldl_recept_b	3284..3332	CDD:459654
LDL-receptor class B 30. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3284..3326
LDL-receptor class B 31. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3335..3378
Ldl_recept_b	3335..3376	CDD:459654
LY	3360..3401	CDD:214531
LDL-receptor class B 32. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3379..3421
LY	3406..3443	CDD:214531