DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6739 and ldlr

DIOPT Version :9

Sequence 1:	NP_609130.1	Gene:	CG6739 / 34037	FlyBaseID:	FBgn0031926	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	XP_002942891.1	Gene:	ldlr / 100495826	XenbaseID:	XB-GENE-962372	Length:	894	Species:	Xenopus tropicalis

Alignment Length:	327	Identity:	81/327 - (24%)
Similarity:	107/327 - (32%)	Gaps:	136/327 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   432 CYGNEFQCHDGSCIPQNWQCDKIKDCQGGEDED-EQCLV--CEPDEFRC--RSNEKCLVEKYRCD 491
            |..:||||.||.|||..|.||...:|:.|.||. |.|.|  |..|.|.|  |.| :|:...::||
Frog    29 CDRSEFQCGDGKCIPYKWICDGSAECKDGSDESPETCKVVTCGADHFSCGGRLN-RCIPLLWKCD 92

  Fly   492 QNIDCMDGSDEQDC-------DEY--GSGDLAPFDESELNAFPRVFTYASFLSPNETNDKVYTYI 547
            ...||.:||||.||       |::  .||.....|          |.....|..::.:|:.|
Frog    93 GQTDCENGSDENDCTRKVCADDQFTCRSGKCISLD----------FVCDEDLDCDDGSDESY--- 144

  Fly   548 TATTDEDAGTETKFQIHQVAAPAPPVNSS----AEEGAGGPKGFVNFRDSKEIMMTSDSETKFKY 608
                                .|||..|.:    .::|...||           :...|.:
Frog   145 --------------------CPAPTCNPAMFQCKDKGICIPK-----------LWACDGD----- 173

  Fly   609 SQRANRTSVKFSVSAPTTPAARTSSAIPSSALVQQRERTTSTTTTSTTTSTTTSSITSTPSITST 673
                              |.....|   .....:.||
Frog   174 ------------------PDCEDGS---DEQHCEGRE---------------------------- 189

  Fly   674 TLIPINAATSEPNPYEVVTSLGGCPPQELRCVSGKCITVSQLCDKQIDCPDAADELMCVYRERPS 738
               ||.  |.:|           |.|.|..|.||:||.:|..||...||.|.:||..||   :|:
Frog   190 ---PIK--TDKP-----------CSPLEFHCGSGECIHMSWKCDGGYDCKDKSDEKDCV---KPT 235

  Fly   739 RR 740
            .|
Frog   236 CR 237

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6739	NP_609130.1	CRD_FZ	314..427	CDD:143549
		LDLa	432..464	CDD:238060	16/31 (52%)
		LDLa	470..505	CDD:238060	15/36 (42%)
		LDLa	697..731	CDD:238060	16/33 (48%)
ldlr	XP_002942891.1	Ldl_recept_a	27..60	CDD:365841	15/30 (50%)
		Ldl_recept_a	68..106	CDD:365841	15/38 (39%)
		LDLa	111..145	CDD:238060	8/66 (12%)
		Ldl_recept_a	149..185	CDD:365841	7/72 (10%)
		Ldl_recept_a	195..231	CDD:365841	17/46 (37%)
		Ldl_recept_a	235..270	CDD:365841	1/3 (33%)
		LDLa	278..308	CDD:381805
		FXa_inhibition	318..352	CDD:373209
		EGF_CA	354..384	CDD:214542
		LY	419..457	CDD:214531
		Ldl_recept_b	439..482	CDD:278487
		Ldl_recept_b	486..525	CDD:278487
		Ldl_recept_b	529..569	CDD:278487
		LY	555..595	CDD:214531
		Ldl_recept_b	616..655	CDD:278487
		FXa_inhibition	674..711	CDD:373209
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000