DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d21 and ERG11

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_011871.1	Gene:	ERG11 / 856398	SGDID:	S000001049	Length:	530	Species:	Saccharomyces cerevisiae

Alignment Length:	545	Identity:	127/545 - (23%)
Similarity:	218/545 - (40%)	Gaps:	111/545 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLGIAVLIMTLVWD---NSRKQWRVNTFEKSRILGPFTIPIVGNGLQALTLRPENFIQRFGDYFN 65
            |:.|...|..:||.   :.||......|        :.||.||:.: ...::|..|   |.:...
Yeast    33 LIIIIPFIYNIVWQLLYSLRKDRPPLVF--------YWIPWVGSAV-VYGMKPYEF---FEECQK 85

  Fly    66 KYGKTFRLWILGECLIYTKDLKYFESILSS-----STLLKKAHLYRFLRDFLGDGLLLSTGN-KW 124
            |||..|...:||..:......|..|.:.::     |.....|||   .....|.|::....| :.
Yeast    86 KYGDIFSFVLLGRVMTVYLGPKGHEFVFNAKLADVSAEAAYAHL---TTPVFGKGVIYDCPNSRL 147

  Fly   125 TSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKT---------CVDLFKFVSLEALD 180
            ..::|.:..|...:..:::|.:      |..|..|.:.|.|.         .:|:........:.
Yeast   148 MEQKKFVKGALTKEAFKSYVPL------IAEEVYKYFRDSKNFRLNERTTGTIDVMVTQPEMTIF 206

  Fly   181 VTTETAMGVQVNAQNEPNFPYTKALKSVVYIE-SKRLASVSMRYNWLFPLAAPLVYRRLQKDIAI 244
            ..:.:.:|.::.|:.:.:|.|       :|.: .|....:    |::|| ..||.:.|
Yeast   207 TASRSLLGKEMRAKLDTDFAY-------LYSDLDKGFTPI----NFVFP-NLPLEHYR------- 252

  Fly   245 MQDFTDKVIRERRAILERARADGTYKPLI---MGDDDIGGKAKMTLLDILLQATI--DNKPLSDV 304
            .:|...|.|            .|||..||   ..::||..:   .|:|.|::.:.  |...::|.
Yeast   253 KRDHAQKAI------------SGTYMSLIKERRKNNDIQDR---DLIDSLMKNSTYKDGVKMTDQ 302

  Fly   305 DIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKLLELKYL 369
            :|...:...:..|..|:.:..:..|..::..|.||:.:|||.:.|| ......:|...|.|:..|
Yeast   303 EIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVL-DGGKKELTYDLLQEMPLL 366

  Fly   370 DCVIKETMRLHPPVPILGRYIPEDLKIGEIT--IPGNTSILLMPYYVYRDPEYFPDPLVFKPERW 432
            :..||||:|:|.|:..|.|.:.:|:.:...:  ||....:|:.|.|.:...||||:...|...||
Yeast   367 NQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRW 431

  Fly   433 MDMKTTS------------------NTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIR---- 475
            .....:|                  ::|   |:||..|...|||:.||..|:..|:|..||
Yeast   432 NKDSASSYSVGEEVDYGFGAISKGVSSP---YLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKW 493

  Fly   476 HYELLPLGADL-KATYTFILSSSTG 499
            ||   |.|..: ...:|.:::..||
Yeast   494 HY---PEGKTVPPPDFTSMVTLPTG 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	114/491 (23%)
ERG11	NP_011871.1	CYP51-like	83..521	CDD:410668	112/483 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R248
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940