DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d21 and CYP704B1

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_177109.3	Gene:	CYP704B1 / 843283	AraportID:	AT1G69500	Length:	524	Species:	Arabidopsis thaliana

Alignment Length:	557	Identity:	139/557 - (24%)
Similarity:	233/557 - (41%)	Gaps:	82/557 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWILLGIAVLIMTLV----WDNSRKQWRVNTFEKSRILGPFTIPIVGNGLQALTLRPENFIQRFG 61
            |.:.|.||.::.:.:    |....|.            ||.|.|:||..::.||    || .|..
plant     1 MSLCLVIACMVTSWIFLHRWGQRNKS------------GPKTWPLVGAAIEQLT----NF-DRMH 48

  Fly    62 DYFNKY---GKTFRLWILGECLIYTKDLKYFESILSS--STLLKKAHLYRFLRDFLGDGLLLSTG 121
            |:..:|   .:|..:.:......|..|....|.:|.:  |...|....:.::...||||:..|.|
plant    49 DWLVEYLYNSRTVVVPMPFTTYTYIADPINVEYVLKTNFSNYPKGETYHSYMEVLLGDGIFNSDG 113

  Fly   122 NKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGK-TCVDLFKFVSLEALDVTTET 185
            ..|..:||..:..|..|.|.:|..::.:...:.:..:.:.|..| ..||:.:.:....||...:.
plant   114 ELWRKQRKTASFEFASKNLRDFSTVVFKEYSLKLFTILSQASFKEQQVDMQELLMRMTLDSICKV 178

  Fly   186 AMGVQVN--AQNEPNFPYTKALKSVVYIESKRLASVSMRYNWLFPLAAPLVYRRLQKDIAIMQDF 248
            ..||::.  |...|...:.||..:...|.:.|......:......:.:..:   |.|.|.::.||
plant   179 GFGVEIGTLAPELPENHFAKAFDTANIIVTLRFIDPLWKMKKFLNIGSEAL---LGKSIKVVNDF 240

  Fly   249 TDKVIRERRAILERARADGTYKPLIMGDDDIGGKAKMTLLDILLQATID-NKPLSDVDIREEVDV 312
            |..|||.|:|.|..|:...|     ..:::...|.|..:|...::.:.| :...::..:|:.|..
plant   241 TYSVIRRRKAELLEAQISPT-----NNNNNNNNKVKHDILSRFIEISDDPDSKETEKSLRDIVLN 300

  Fly   313 FIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKLLE------------ 365
            |:.||.|||.:.::.|::.|..:..|.|.:|.||..:  ....|..|.|.|.:
plant   301 FVIAGRDTTATTLTWAIYMIMMNENVAEKLYSELQEL--EKESAEATNTSLHQYDTEDFNSFNEK 363

  Fly   366 ---------------LKYLDCVIKETMRLHPPVPILGRYIPEDLKIGEITIPGNTS------ILL 409
                           |.||..||.||:||:|.||...:.:.||     ..:|..|.      :..
plant   364 VTEFAGLLNYDSLGKLHYLHAVITETLRLYPAVPQDPKGVLED-----DMLPNGTKVKAGGMVTY 423

  Fly   410 MPYYVYR-DPEYFPDPLVFKPERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKV 473
            :||.:.| :..:..|..:||||||:......|..|..:..|.:||:.|:|:..|.||||..::.:
plant   424 VPYSMGRMEYNWGSDAALFKPERWLKDGVFQNASPFKFTAFQAGPRICLGKDSAYLQMKMAMAIL 488

  Fly   474 IRHYE--LLPLGADLKATYTFILSSSTGNNVGLKPRT 508
            .|.|:  |:| ...:|.....|||.:.|..|.:..|:
plant   489 CRFYKFHLVP-NHPVKYRMMTILSMAHGLKVTVSRRS 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	125/491 (25%)
CYP704B1	NP_177109.3	PLN03195	1..524	CDD:215627	138/555 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910