Protein Alignment Cyp4d21 and cyp46a1.2

DIOPT Version :10

• Sequence 1: NP_609129.2
• Gene: Cyp4d21 / 34036
• FlyBaseID: FBgn0031925
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_001072550.1
• Gene: cyp46a1.2 / 780005
• XenbaseID: XB-GENE-5802444
• Length: 503
• Species: Xenopus tropicalis
• Alignment Length: 542
• Identity: 145/542 - (26%)
• Similarity: 247/542 - (45%)
• Gaps: 76/542 - (14%)

  Fly     1 MWILLG-IAVLIMTLV-----------------WDNSRKQWRVNTFEKSRILGPFTIP----IVG 43
            :|.:|| .|:|::.|:                 :|:              |.||   |    |.|
 Frog     3 LWAILGWAALLLLALILICFLLYCGYIHYIHMKYDH--------------IPGP---PRDSFIFG 50

  Fly    44 NGLQALTLRPENFI--QRFGDYFNKYGKTFRLWILGECLIYTKDLKYFESILSSSTLLKKAHLYR 106
            :....|.|..||.:  ..|.|:.:|||...|:..|.:..:.....:..:..|.|...||. ..|.
 Frog    51 HSTALLKLVNENLLMYDYFLDWVHKYGPVMRINGLHKVAVLVASPEGIKEFLMSPKYLKD-EFYD 114

  Fly   107 FLRDFLGD-----GLLLSTG-NKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGK 165
            |.....|:     |||.... :.|..:|:::.|||....|...:...:..:..::|||...:|.|
 Frog   115 FFGSLFGERLMGKGLLTDRDYDHWHKQRRIMDPAFSRTYLMGLMGPFNEKAEELMEKLSENSDRK 179

  Fly   166 TCVDLFKFVSLEALDVTTETAMGVQVNAQNEPNFPYTKALKSVVYIESKRLASVSMRYNWLFPLA 230
            ..|::....|...|||..:...|:::|:.|:...|:.:|: |:|...|..:.:..::|:    ||
 Frog   180 CEVNMHDMFSKVTLDVIGKVGFGMELNSLNDDQTPFPRAI-SLVMKGSVEIRNPMIKYS----LA 239

  Fly   231 APLVYRRLQKDIAIMQDFTDKVIRERRAILERARADGTYKPLIMGDDDIGGKAKMTLLDILLQAT 295
            ...:.|::|:.|.:::. |.|...|||   ::...||...|             :.:|..:|:.|
 Frog   240 KRGLIRKVQESIRLLRQ-TGKECIERR---QKQIQDGEEIP-------------VDILTQILRGT 287

  Fly   296 IDNKPLSDVDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQ 360
            ...|......:.:....|..||.:||.:.:|.|:.::.|:|::.:....|:..|:|...|  :..
 Frog   288 ALEKDCDPETLLDNFVTFFIAGQETTANQLSFAVMSLGRNPEILKKAQAEIDEVIGSKRD--IEY 350

  Fly   361 TKLLELKYLDCVIKETMRLHPPVPILGRYIPEDLKIGEITIPGNTSILLMPYYVYRDPEYFPDPL 425
            ..|.:|.||..|:|||:||:|..|...|.:..::.|.|:.||||.:::|..|.:.|..:|:.|||
 Frog   351 EDLGKLSYLSQVLKETLRLYPTAPGTSRTLENEIVIDEVRIPGNVTLMLNSYVMGRMEQYYKDPL 415

  Fly   426 VFKPERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYEL-LPLGADLKAT 489
            :|.|:|:   ...:..|...|.|||.||:|||||.|:.::.|.:::|.::.||. |..|...|..
 Frog   416 MFNPDRF---SPDAPKPYFTYFPFSLGPRNCIGQVFSQMEAKVVMAKFLQRYEFELAEGQSFKIL 477

  Fly   490 YTFILSSSTGNNVGLKPRTRVK 511
            .|..|....|....|:.||..|
 Frog   478 DTGTLRPLDGVICRLRSRTNNK 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	CYP4	68..502	CDD:410721	120/440 (27%)
cyp46a1.2	NP_001072550.1	CYP46A1-like	66..490	CDD:410706	124/451 (27%)