DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d21 and Cyp4f18

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_077764.2	Gene:	Cyp4f18 / 72054	MGIID:	1919304	Length:	524	Species:	Mus musculus

Alignment Length:	537	Identity:	166/537 - (30%)
Similarity:	261/537 - (48%)	Gaps:	69/537 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WILLGIA------VLIMTLVWDNSRKQWRVNTFEKSRILGPFTIP-----IVGNGLQALTLRPEN 55
            |:||.:|      ..|:|.::         ..||.|..|..|..|     |:|: |..:....|.
Mouse    19 WLLLLLAGASCLLAYILTPIY---------GVFENSLRLRCFPQPPKRNWILGH-LGLIQSSEEG 73

  Fly    56 FIQRFGDYFNKYGKTFR---LWILGEC--LIYTKDLKYFESILSSSTLL--KKAHLYRFLRDFLG 113
            .:     |.....:|||   .|.:|..  :|......:.:.::.:..|:  |....||||:.:||
Mouse    74 LL-----YIQSLVRTFRDACCWWVGPLHPVIRIFHPAFIKPVVLAPALVAPKDTVFYRFLKPWLG 133

  Fly   114 DGLLLSTGNKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYAD-GKTCVDLFKFVSLE 177
            ||||:|||:||:..|::|.|||||..|:.:|::.:.::.||..|.:..|. |...:::|:.:||.
Mouse   134 DGLLMSTGDKWSRHRRMLTPAFHFNILKPYVKVFNDSTNIMHAKWQRLASKGSAYLNMFEHISLM 198

  Fly   178 ALDVTTETAMGVQVNAQNEPNFPYTKALKSVVYIESKRLASVSMRYNWLFPLAAPLVY------R 236
            .||...:.......|.|.:|:...|..|:         |:::..|.:....|...|.|      .
Mouse   199 TLDSLQKCVFSFDSNCQEKPSEYITAILE---------LSTLVARRHQRLLLHVDLFYYLTHDGM 254

  Fly   237 RLQKDIAIMQDFTDKVIRE-RRAILERARADGTYKPLIMGDDDIGGKAKMTLLD----ILLQATI 296
            |.:|...::.||||.|||| ||.:|::.           |.|.:..|||...||    :||....
Mouse   255 RFRKACRLVHDFTDAVIRERRRTLLDQG-----------GVDVLKAKAKAKTLDFIDVLLLSKDE 308

  Fly   297 DNKPLSDVDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQT 361
            ..|.|||.|||.|.|.|:|.|.|||.||:|..|:.::|||:.||...:|:..:|.......:...
Mouse   309 HGKALSDEDIRAEADTFMFGGHDTTASGLSWILYNLARHPEYQERCRQEVRELLRDREPEEIEWD 373

  Fly   362 KLLELKYLDCVIKETMRLHPPVPILGRYIPEDLKI--GEITIPGNTSILLMPYYVYRDPEYFPDP 424
            .|.:|.:|...|||::||||||..:.|...:|:.:  |.: ||......:..:..:.:|..:|||
Mouse   374 DLAQLPFLTMCIKESLRLHPPVTAISRCCTQDIVLPDGRV-IPKGVISRISIFGTHHNPAVWPDP 437

  Fly   425 LVFKPERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLPLGADLKAT 489
            .|:.|.|: |........|||:||||:||:|||||.||..:||..::..:..:.:||...:.:..
Mouse   438 EVYDPFRF-DADNVKGRSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRVLPDDKEPRRK 501

  Fly   490 YTFILSSSTGNNVGLKP 506
            ...||.:..|..:.::|
Mouse   502 PELILRAEGGLWLKVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	151/472 (32%)
Cyp4f18	NP_077764.2	p450	52..516	CDD:365848	154/491 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845240
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750