Protein Alignment Cyp4d21 and TBXAS1

DIOPT Version :10

• Sequence 1: NP_609129.2
• Gene: Cyp4d21 / 34036
• FlyBaseID: FBgn0031925
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Alignment Length: 587
• Identity: 120/587 - (20%)
• Similarity: 226/587 - (38%)
• Gaps: 141/587 - (24%)

  Fly     3 ILLGIAVLIMTLVWDNSRKQWRVNTFEKSRILG---PFTIPIVGNGLQALTLRPENF-------- 56
            :.|.:|:|.: |.|      :..:.|.:...||   |...|.:||    ||...:.|
Human    18 VALSVALLAL-LKW------YSTSAFSRLEKLGLRHPKPSPFIGN----LTFFRQGFWESQMELR 71

  Fly    57 -----------------------------IQRFGDYFNKYGKTFRLWILGECLIYTKDLKYFESI 92
                                         ::.|.::.|:.........:.:.:::.:|.::.|
Human    72 KLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRDKRWEE-- 134

  Fly    93 LSSSTLLKKAHLYRFLRDFLGD-GLLL-------STGNKWTSRR----KVLAPA-----FHFKCL 140
                  ::.|.:..|..:.|.: |||:       ..|.:...:|    ::..|:     .|:..|
Human   135 ------VRGALMSAFSPEKLNELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLHYATL 193

  Fly   141 E-NFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFVSLEALDVTTETAMGVQVNAQNEPNFPYTKA 204
            . ..|.::.:...:::..||.||:.....|:.:.......||....|.|..|::...|..|:.|.
Human   194 PFCMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKH 258

  Fly   205 LKSVVYIESKRLASVSMRYNWLFP-LAAPLVYRRLQKDIAIMQDFTDKVI------RERRAILER 262
            .|........|...|.:   ..|| :..||......|:...:..|.:|:|      |:::|..||
Human   259 CKRFFEFCIPRPILVLL---LSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEER 320

  Fly   263 AR--------ADGTYKPLIMGDDDIGGKAKMTLLDILL------------QATIDNKPLSDVDIR 307
            .|        |..:..|:.:.|.||       :.|:..            |.:...:||:..:|.
Human   321 RRDFLQMVLDARHSASPMGVQDFDI-------VRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIV 378

  Fly   308 EEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKLLE------- 365
            .:..:|:.||.:..|:.:|.|.:.::.:|..||.:..|:          .|.:.|.:.
Human   379 GQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV----------DVFKEKHMAPEFCSLE 433

  Fly   366 --LKYLDCVIKETMRLHPPVPILGRYIPEDLKIGEITIPGNTSILLMPYYVYRDPEYFPDPLVFK 428
              |.|||.||.||:|::||.....|...:|.::....||....:.:....::.|||::|.|..|.
Human   434 EGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFN 498

  Fly   429 PERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYEL-------LPLGADL 486
            |||: ..:......|..|:||.:||::|:|.:...|::|..:..|:..:..       :||..:.
Human   499 PERF-TAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLES 562

  Fly   487 KA 488
            |:
Human   563 KS 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	CYP4	68..502	CDD:410721	103/482 (21%)
TBXAS1	NP_001159725.2	cytochrome_P450	73..573	CDD:477761	105/521 (20%)