DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d21 and Cyp4f37

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001093657.1	Gene:	Cyp4f37 / 677156	MGIID:	3780112	Length:	546	Species:	Mus musculus

Alignment Length:	547	Identity:	164/547 - (29%)
Similarity:	269/547 - (49%)	Gaps:	81/547 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 W--ILLGIA--VLIMTLVWDNS---------------RKQW---RVNTFEKSRILGPFTIPIVGN 44
            |  :|||.|  :|...|.|..|               ::.|   .:...|.:.           .
Mouse    19 WHLLLLGAASWILARILAWTYSFCENCSRLRCFPQPPKRNWFLGHLGMIEHNE-----------E 72

  Fly    45 GLQALTLRPENFIQRFGDYFNKYGKTFR----LWILGECL--IYTKDLKYFESILSSSTLL--KK 101
            |:|.:|               :.|:|:|    .| ||..:  :...|..:...:|.:|.|:  |.
Mouse    73 GMQLMT---------------EAGQTYRDVHLCW-LGPVIPVLRIVDPAFVAPLLLASALVAPKD 121

  Fly   102 AHLYRFLRDFLGDGLLLSTGNKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNY-ADGK 165
            ...:.|::.:|||||.|::|:||:..|::|.|||||..|:.:|:|.:::..||..|.|:. ::|.
Mouse   122 TTFHTFVKPWLGDGLFLNSGDKWSRHRRLLTPAFHFDILKPYVKIFNQSVNIMHAKWKHLSSEGS 186

  Fly   166 TCVDLFKFVSLEALDVTTETAMGVQVNAQNEPNFPYTKALKSVVYIESKRLASVSMRYNWLFPLA 230
            ..:::|:.:||..||...:...|...|.|..|: .|..|:..:..:..||...:.:..::|:...
Mouse   187 ARLEMFEHISLMTLDSLQKCLFGFDSNCQESPS-EYISAILELSSLVIKRSHQLFLFVDFLYYHT 250

  Fly   231 APLVYRRLQKDIAIMQDFTDKVIRERRAILERARADGTYKPLIMGDDDIGGKAK---MTLLDILL 292
            |.  .||.:|...::.:|||.||||||..|.....|...|          .|.|   :..:|:||
Mouse   251 AD--GRRFRKACDLVHNFTDAVIRERRHTLSSQNHDEFLK----------SKTKSKTLDFIDVLL 303

  Fly   293 QATIDN-KPLSDVDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVL-GPDPD 355
            .|..:: |.|||.|||.|.|.|:|.|.|||.|.:|..|:.::|||:.||...:|:..:| |.:|.
Mouse   304 LAKDEHGKELSDEDIRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQEVQELLRGREPQ 368

  Fly   356 ASVTQTKLLELKYLDCVIKETMRLHPPVPILGRYIPEDLKI--GEITIPGNTSILLMPYYVYRDP 418
             .:....|.:|.:|...|||::||||||..|.|....|:.:  |.:...||..::.: :.::.:|
Mouse   369 -EIEWDDLAQLPFLTMCIKESLRLHPPVIDLLRRCTRDIVLPDGRVIPKGNICVISI-FGIHHNP 431

  Fly   419 EYFPDPLVFKPERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLPLG 483
            ..:|||.|:.|.|: |.:.....||||:||||:||:|||||.||..:|...::..:..:.:||..
Mouse   432 SVWPDPEVYDPFRF-DPENAHKRPPLAFIPFSAGPRNCIGQTFAMNEMMVALALTLLRFRILPDD 495

  Fly   484 ADLKATYTFILSSSTGNNVGLKPRTRV 510
            .:.:.....||.:..|..:.::|.:.|
Mouse   496 KEPRRKPEIILRAEGGLWLRVEPLSTV 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	147/462 (32%)
Cyp4f37	NP_001093657.1	CYP4F	74..515	CDD:410772	150/472 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845172
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750