DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d21 and Cyp4a31

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_964002.2	Gene:	Cyp4a31 / 666168	MGIID:	3028580	Length:	509	Species:	Mus musculus

Alignment Length:	467	Identity:	143/467 - (30%)
Similarity:	247/467 - (52%)	Gaps:	38/467 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 LQALTLRPENFIQRFGDYFNKYGKTFRLWILGECLIYTKDLKYFESILSSSTLLKKAH-LYRFLR 109
            ||.:....|||...|..:|  :|....|      .:|..|  |.:.||..|.  .||: .||.|.
Mouse    71 LQEIVSCIENFPSAFPRWF--WGSKAYL------TVYDPD--YMKVILGRSD--PKANGAYRLLA 123

  Fly   110 DFLGDGLLLSTGNKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFV 174
            .::|.||||..|..|...||:|.||||:..|:.:|:.|..:..:|::|.:..|...:.:::|:.:
Mouse   124 PWIGYGLLLLNGQSWFQHRKMLTPAFHYDILKTYVKNMADSIRLMLDKWERLAGQDSSIEIFQHI 188

  Fly   175 SLEALDVTTETAMGVQVNAQNEPNF-PYTKALKSVVYIESKRLASVSMRYNWLFPLAAPLVYRRL 238
            ||..||...:.|...:.:.|.:.|: .|.:|:..:..:...|:.::..:.:.::.|::   ..||
Mouse   189 SLMTLDTVMKCAFSHKGSVQVDGNYKTYLQAIGDLNNLVHSRVRNMFHQNDTIYKLSS---NGRL 250

  Fly   239 QKDIA-IMQDFTDKVIRERRAILERARADGTYKPLIMGDDDIGGKAKMTLLDILLQATIDNK-PL 301
            ..... :..|.||.||:.|:   ::.:.:|..       ::|..|.::..|||||.|.::|: .:
Mouse   251 SNQACQLAHDHTDGVIKMRK---DQLQDEGEL-------ENIKKKRRLDFLDILLFARMENEDSM 305

  Fly   302 SDVDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKLLEL 366
            ||.|:|.|||.|:..|.|||.||||...:|::.||:.|:...||:.|:||  ..:|:|...|.::
Mouse   306 SDKDLRAEVDTFMIEGHDTTASGVSWIFYALATHPEHQQRCREEVQSLLG--DGSSITWDHLDQI 368

  Fly   367 KYLDCVIKETMRLHPPVPILGRYIPEDLKIGE-ITIPGNTSILLMPYYVYRDPEYFPDPLVFKPE 430
            .|....|||.:||:||||.:||.:...:...: .::|....:.|..|.::.:|:.:|:|.||.|.
Mouse   369 PYTTMCIKEALRLYPPVPSIGRELSTSVTFPDGCSLPKGVQVTLSIYGLHHNPKVWPNPEVFDPS 433

  Fly   431 RWM-DMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLPLGADLKATYT-FI 493
            |:. |....|:    :::|||.|.:||||::||..::|.:::..:..:||||....:..:.. |:
Mouse   434 RFAPDSPRHSH----SFLPFSGGARNCIGKQFAMSELKVIVALTLLRFELLPDPTRVPMSLARFV 494

  Fly   494 LSSSTGNNVGLK 505
            |.|..|..:.||
Mouse   495 LKSKNGIYLHLK 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	136/441 (31%)
Cyp4a31	NP_964002.2	p450	52..503	CDD:278495	141/462 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845126
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750