DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d21 and CYP4F12

DIOPT Version :9

Sequence 1:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_076433.3	Gene:	CYP4F12 / 66002	HGNCID:	18857	Length:	524	Species:	Homo sapiens

Alignment Length:	521	Identity:	164/521 - (31%)
Similarity:	270/521 - (51%)	Gaps:	37/521 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WILLGIAVLIMTLVWDNSR-KQWRVNTFEKSRILGPFTIPIVGN---GLQALTLRPENFIQRFGD 62
            |:||    |::...|..:| ..|....:...|.|..|..|...|   |...|....|..::....
Human    19 WLLL----LLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWFWGHLGLITPTEEGLKNSTQ 79

  Fly    63 YFNKYGKTFRLWILGECLIYTKDLKYFESILS----SSTLLKKAHLY-RFLRDFLGDGLLLSTGN 122
            ....|.:.|.:| ||..:.:.. |.:.::|.|    |:.:..|.:|: |||:.:||:|:|||.|:
Human    80 MSATYSQGFTVW-LGPIIPFIV-LCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGD 142

  Fly   123 KWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYA-DGKTCVDLFKFVSLEALDVTTETA 186
            ||:..|::|.|||||..|::::.|.::::.||::|.::.| :|.:.:|:|:.:||..||...:..
Human   143 KWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCI 207

  Fly   187 MGVQVNAQNEPNFPYTKALKSVVYIESKRLASVSMRYNWLFPLAAPLVYRRLQKDIAIMQDFTDK 251
            .....:.|..|: .|...:..:..:..||...:....::|:.|:..  .||..:...::.||||.
Human   208 FSFDSHCQERPS-EYIATILELSALVEKRSQHILQHMDFLYYLSHD--GRRFHRACRLVHDFTDA 269

  Fly   252 VIRERRAILERARADGTYKPLIMGDDDIGGKAKMTLLD----ILLQATIDNKPLSDVDIREEVDV 312
            ||||||..|.....|..:|          .|||...||    :||....|.|.|||.|||.|.|.
Human   270 VIRERRRTLPTQGIDDFFK----------DKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADT 324

  Fly   313 FIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKLLELKYLDCVIKETM 377
            |:|.|.|||.||:|..|:.::|||:.||...:|:..:|.......:....|.:|.:|...:||::
Human   325 FMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESL 389

  Fly   378 RLHPPVPILGRYIPEDLKI--GEITIPGNTSILLMPYYVYRDPEYFPDPLVFKPERWMDMKTTSN 440
            |||||.|.:.|...:|:.:  |.: ||...:.|:....|:.:|..:|||.|:.|.|: |.:.:..
Human   390 RLHPPAPFISRCCTQDIVLPDGRV-IPKGITCLIDIIGVHHNPTVWPDPEVYDPFRF-DPENSKG 452

  Fly   441 TPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLPLGADLKATYTFILSSSTGNNVGLK 505
            ..|||:||||:||:|||||.||..:||.:::.::.|:..||...:.:.....|:.:..|..:.::
Human   453 RSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVE 517

  Fly   506 P 506
            |
Human   518 P 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	151/461 (33%)
CYP4F12	NP_076433.3	p450	52..506	CDD:306555	151/470 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154823
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750